Kenny K. Wong
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View article: Increased Respiratory Syncytial Virus-Associated Hospitalizations and Ambulatory Visits in Very Preterm Infants in the First Year of Life following Discontinuation of Access to Palivizumab
Increased Respiratory Syncytial Virus-Associated Hospitalizations and Ambulatory Visits in Very Preterm Infants in the First Year of Life following Discontinuation of Access to Palivizumab Open
From 2002 to 2023, palivizumab was the only intervention to reduce respiratory syncytial virus (RSV)-associated hospitalizations in high-risk infants in Canada but advances in RSV prevention are drastically changing this landscape. Eligibi…
View article: A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials
A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials Open
The xCures platform aggregates, organizes, structures, and normalizes clinical EMR data across care sites, utilizing advanced technologies for near real-time access. The platform generates data in a format to support clinical care, acceler…
View article: A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials
A Health Care Clinical Data Platform for Rapid Deployment of Artificial Intelligence and Machine Learning Algorithms for Cancer Care and Oncology Clinical Trials Open
The xCures platform aggregates, organizes, structures, and normalizes clinical EMR data across care sites, utilizing advanced technologies for near real-time access. The platform generates data in a format to support clinical care, acceler…
View article: AI-Augmented Clinical Decision Support in a Patient-Centric Precision Oncology Registry
AI-Augmented Clinical Decision Support in a Patient-Centric Precision Oncology Registry Open
Purpose: xDECIDE is a clinical decision support system, accessed through a web portal and powered by a “Human-AI Team,” that offers oncology health care providers with treatment options personalized for their cancer patients and outcomes t…
View article: Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA
Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA Open
Peptide nucleic acids (PNAs) are antisense molecules with excellent polynucleotide hybridization properties; they are resistant to nuclease degradation but often have poor cell permeability leading to moderate cellular activity and limited…
View article: Current status of cardiopulmonary resuscitation training and automatic external defibrillator availability in high schools in Halifax, Nova Scotia, Canada
Current status of cardiopulmonary resuscitation training and automatic external defibrillator availability in high schools in Halifax, Nova Scotia, Canada Open
Background School-based cardiopulmonary resuscitation (CPR) training and early use of an automated external defibrillator (AED) have proven to increase the survival of victims of sudden cardiac arrest (SCA). This study aimed to determine t…
View article: Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease
Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease Open
Persistence of CAA and MACE are more strongly associated with baseline severity CAA than with acute adjuvant anti-inflammatory therapy. Patients who received late adjunctive therapy are at higher risk for worse outcomes.
View article: AI-Augmented Clinical Decision Support in a Patient-Centric Precision Oncology Registry
AI-Augmented Clinical Decision Support in a Patient-Centric Precision Oncology Registry Open
Purpose xDECIDE is a clinical decision support system, accessed through a web portal and powered by a “Human-AI Team”, that offers oncology healthcare providers a set of treatment options personalized for their cancer patients, and provide…
View article: Alternative to Body Surface Area as a Solution to Correct Systematic Bias in Pediatric Echocardiography z Scores
Alternative to Body Surface Area as a Solution to Correct Systematic Bias in Pediatric Echocardiography z Scores Open
View article: Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team
Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team Open
View article: Female and male perspectives on male partner roles in expanded carrier screening
Female and male perspectives on male partner roles in expanded carrier screening Open
View article: Cardiovascular Care Delivery During the Second Wave of COVID-19 in Canada
Cardiovascular Care Delivery During the Second Wave of COVID-19 in Canada Open
View article: Preparing for CBME: How often are faculty observing residents?
Preparing for CBME: How often are faculty observing residents? Open
Background The Royal College of Physicians and Surgeons of Canada officially launched ‘Competence by Design’ in July 2017, moving from time-based to outcomes-based training. Transitioning to competency-based medical education (CBME) necess…
View article: A "tandem-reflex” strategy minimizes results delivery time for couples undergoing carrier screening
A "tandem-reflex” strategy minimizes results delivery time for couples undergoing carrier screening Open
View article: PREPARING FOR CBME: HOW OFTEN ARE FACULTY OBSERVING RESIDENTS?
PREPARING FOR CBME: HOW OFTEN ARE FACULTY OBSERVING RESIDENTS? Open
BACKGROUND Transitioning to competency-based medical education (CBME) necessitates change in resident assessment. A greater frequency of resident observation will be required to adequately assess whether entrustable professional activities…
View article: 259: Copy number variant calling on a 176-disease expanded carrier screening panel
259: Copy number variant calling on a 176-disease expanded carrier screening panel Open
View article: La saturométrie pour mieux dépister la cardiopathie congénitale grave chez les nouveau-nés
La saturométrie pour mieux dépister la cardiopathie congénitale grave chez les nouveau-nés Open
La saturométrie est un moyen simple, sécuritaire, non invasif et démontré d’améliorer le\ndépistage de la cardiopathie congénitale grave chez les nouveau-nés. Pourtant, ce test\nn’est pas encore utilisé systématiquement au Canada. Le prése…
View article: Pulse oximetry screening in newborns to enhance detection of critical congenital heart disease
Pulse oximetry screening in newborns to enhance detection of critical congenital heart disease Open
Pulse oximetry screening is safe, noninvasive, easy to perform and proven to enhance detection of critical congenital heart disease in newborns. However, this test has yet to be adopted as routine practice in Canada. The present practice p…
View article: Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At‐Risk Couples
Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At‐Risk Couples Open
Expanded carrier screening (ECS) analyzes dozens or hundreds of recessive genes to determine reproductive risk. Data on the clinical utility of screening conditions beyond professional guidelines are scarce. Individuals underwent ECS for u…
View article: Development and validation of an expanded carrier screen that optimizes sensitivity via full-exon sequencing and panel-wide copy-number-variant identification
Development and validation of an expanded carrier screen that optimizes sensitivity via full-exon sequencing and panel-wide copy-number-variant identification Open
Purpose By identifying pathogenic variants across hundreds of genes, expanded carrier screening (ECS) enables prospective parents to assess risk of transmitting an autosomal recessive or X-linked condition. Detection of at-risk couples dep…
View article: Cost‐effectiveness analysis of potentially curative and combination treatments for hepatocellular carcinoma with person‐level data in a Canadian setting
Cost‐effectiveness analysis of potentially curative and combination treatments for hepatocellular carcinoma with person‐level data in a Canadian setting Open
Patients with early‐stage hepatocellular carcinoma ( HCC ) are potential candidates for curative treatments such as radiofrequency ablation ( RFA ), surgical resection ( SR ), or liver transplantation ( LT ), which have demonstrated a sign…
View article: Systematic design and comparison of expanded carrier screening panels
Systematic design and comparison of expanded carrier screening panels Open
PurposeThe recent growth in pan-ethnic expanded carrier screening (ECS) has raised questions about how such panels might be designed and evaluated systematically. Design principles for ECS panels might improve clinical detection of at-risk…
View article: 185: The impact of copy number analysis in expanded carrier screening
185: The impact of copy number analysis in expanded carrier screening Open
View article: Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease
Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease Open
Congenital heart disease is the most common congenital malformation and approximately 3 in 1000 newborns have critical congenital heart disease (CCHD). Timely diagnosis affects morbidity, mortality, and disability, and newborn pulse oximet…
View article: Systematic Design and Comparison of Expanded Carrier Screening Panels
Systematic Design and Comparison of Expanded Carrier Screening Panels Open
Purpose The recent growth in pan-ethnic expanded carrier screening (ECS) has raised questions about how such panels might be designed and evaluated systematically. Design principles for ECS panels might improve clinical detection of at-ris…
View article: Assessing vaccine safety within Ontario’s Universal Influenza Immunization Program, 2012-2013 to 2014-2015
Assessing vaccine safety within Ontario’s Universal Influenza Immunization Program, 2012-2013 to 2014-2015 Open
This assessment found a low rate of reported adverse events following influenza vaccines administered in Ontario. Most reported events were mild and resolved completely. The findings were consistent with the very good safety profile of inf…
View article: Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At-Risk Couples
Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At-Risk Couples Open
Purpose Expanded carrier screening (ECS) analyzes dozens or hundreds of recessive genes for determining reproductive risk. Data on clinical utility of screening conditions beyond professional guidelines is scarce. Methods Individuals under…
View article: Genetic Counselors in Startup Companies: Redefining the Genetic Counselor Role
Genetic Counselors in Startup Companies: Redefining the Genetic Counselor Role Open
Genetic counselors (GCs) have recently begun moving into non‐clinic based roles in increasing numbers. A relatively new role for GCs is working for startup companies. Startups are newly established companies in the phase of developing and …
View article: Data-driven approach of CUSUM algorithm in temporal aberrant event detection using interactive web applications
Data-driven approach of CUSUM algorithm in temporal aberrant event detection using interactive web applications Open
View article: 173: Ethnic variability in FMR1 CGG repeat size distribution predicts differences in inter-ethnic fragile X syndrome incidence
173: Ethnic variability in FMR1 CGG repeat size distribution predicts differences in inter-ethnic fragile X syndrome incidence Open