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View article: Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics
Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics Open
The increasing prevalence of bone and cartilage injuries presents a persistent clinical challenge in orthopaedic medicine. Current standard-of-care approaches and regenerative strategies, including cell-based therapies and conventional bio…
View article: Extracellular vesicles in osteoimmunomodulation: Orchestrating immune-driven bone regeneration
Extracellular vesicles in osteoimmunomodulation: Orchestrating immune-driven bone regeneration Open
Large bone fractures pose a substantial challenge to orthopedists and place a significant burden on patients and healthcare systems, necessitating innovative therapeutic strategies. Modulating the interactions between the immune and skelet…
View article: Engineering Extracellular Vesicle Production through Magnetic Ion Channel Activation for Bone Regeneration
Engineering Extracellular Vesicle Production through Magnetic Ion Channel Activation for Bone Regeneration Open
Bone disorders represent a significant global health challenge. Extracellular vesicles (EVs) are emerging as a promising nanotherapeutic approach for bone regeneration, addressing the translation barriers associated with cell-based therapi…
View article: Harnessing μ‐X‐Ray Fluorescence Spectroscopy as a Tool to Assess Extracellular Vesicle‐Induced Biomineralization
Harnessing μ‐X‐Ray Fluorescence Spectroscopy as a Tool to Assess Extracellular Vesicle‐Induced Biomineralization Open
Bone cell‐derived extracellular vesicles (EVs) have been increasingly investigated as novel acellular strategies for bone regeneration due to their pro‐regenerative potency. The evaluation of such bone repair enhancement strategies commonl…
View article: Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives
Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives Open
Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an apprec…
View article: Biofabricated osteoblast-derived nanovesicles as extracellular vesicle mimics for bone repair
Biofabricated osteoblast-derived nanovesicles as extracellular vesicle mimics for bone repair Open
Osteoblast-derived extracellular vesicles (EVs) have demonstrated therapeutic utility for bone repair as transporters of key biomolecules capable of accelerating biomineralisation and tissue repair. The clinical translation of these biolog…
View article: Mechanism study of structural functional dual biomimetic composite bone scaffold for repair of mandibular defects in rabbits
Mechanism study of structural functional dual biomimetic composite bone scaffold for repair of mandibular defects in rabbits Open
Objectives: Mandibular issues resulting from injury, gum disease, or congenital defects can restrict chewing ability, impair speech, and cause facial disfigurement, significantly affecting the patient's quality of life. In our previous stu…
View article: Improving predictability of additively manufactured Ti-6Al-4 V lattices for orthopaedic devices: A parametric and struts angle study
Improving predictability of additively manufactured Ti-6Al-4 V lattices for orthopaedic devices: A parametric and struts angle study Open
The advancement of metal additive manufacturing has recently enabled the integration of porous lattice regions into orthopaedic devices. Despite the increased utilisation of various metamaterials there remains limited understanding of how …
View article: Additively manufactured bioceramic scaffolds based on triply periodic minimal surfaces for bone regeneration
Additively manufactured bioceramic scaffolds based on triply periodic minimal surfaces for bone regeneration Open
The study focused on the effects of a triply periodic minimal surface (TPMS) scaffolds, varying in porosity, on the repair of mandibular defects in New Zealand white rabbits. Four TPMS configurations (40%, 50%, 60%, and 70% porosity) were …
View article: Angiogenesis-promoting composite TPMS bone tissue engineering scaffold for mandibular defect regeneration
Angiogenesis-promoting composite TPMS bone tissue engineering scaffold for mandibular defect regeneration Open
Mandibular defects severely impact the patient’s quality of life and are difficult problems to treat in the clinical setting. Due to the limitations of current gold-standard therapies, there is a tremendous need for tissue engineerin…
View article: Laser texturing of additively manufactured implants: A tool to programme biological response
Laser texturing of additively manufactured implants: A tool to programme biological response Open
The advent of additive manufacturing (AM) is rapidly shaping healthcare technologies pushing forward personalisation and enhanced implant functionalisation to improve clinical outcomes. AM techniques such as powder bed fusion (PBF) have be…
View article: Study on the effect of protein lysine lactylation modification in macrophages on inhibiting periodontitis in rats
Study on the effect of protein lysine lactylation modification in macrophages on inhibiting periodontitis in rats Open
Background Protein lysine lactylation (Kla) has been proved to be closely related to inflammatory diseases, but its role in periodontitis (PD) is unclear. Therefore, this study aimed to establish the global profiling of Kla in PD models in…
View article: Bioengineering extracellular vesicles: smart nanomaterials for bone regeneration
Bioengineering extracellular vesicles: smart nanomaterials for bone regeneration Open
In the past decade, extracellular vesicles (EVs) have emerged as key regulators of bone development, homeostasis and repair. EV-based therapies have the potential to circumnavigate key issues hindering the translation of cell-based therapi…
View article: Epigenetic Reprogramming via Synergistic Hypomethylation and Hypoxia Enhances the Therapeutic Efficacy of Mesenchymal Stem Cell Extracellular Vesicles for Bone Repair
Epigenetic Reprogramming via Synergistic Hypomethylation and Hypoxia Enhances the Therapeutic Efficacy of Mesenchymal Stem Cell Extracellular Vesicles for Bone Repair Open
Mesenchymal stem cells (MSCs) are a promising cell population for regenerative medicine applications, where paracrine signalling through the extracellular vesicles (EVs) regulates bone tissue homeostasis and development. MSCs are known to …
View article: GelMA Hydrogel Reinforced with 3D Printed PEGT/PBT Scaffolds for Supporting Epigenetically-Activated Human Bone Marrow Stromal Cells for Bone Repair
GelMA Hydrogel Reinforced with 3D Printed PEGT/PBT Scaffolds for Supporting Epigenetically-Activated Human Bone Marrow Stromal Cells for Bone Repair Open
Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to accelerate stem cells to form mineralised tissues. Gelatine methacryloyl (GelMA) hydrogels provide a favourable microenvironment to facilitat…
View article: An ECM-Mimetic Hydrogel to Promote the Therapeutic Efficacy of Osteoblast-Derived Extracellular Vesicles for Bone Regeneration
An ECM-Mimetic Hydrogel to Promote the Therapeutic Efficacy of Osteoblast-Derived Extracellular Vesicles for Bone Regeneration Open
The use of extracellular vesicles (EVs) is emerging as a promising acellular approach for bone regeneration, overcoming translational hurdles associated with cell-based therapies. Despite their potential, EVs short half-life following syst…
View article: Photocurable antimicrobial silk‐based hydrogels for corneal repair
Photocurable antimicrobial silk‐based hydrogels for corneal repair Open
Corneal transplantation is the current gold standard treatment to restore visual acuity to patients with severe corneal diseases and injuries. Due to severe donor tissue shortage, efforts to develop a corneal equivalent have been made but …
View article: Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway
Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway Open
For elderly or patients with oxidative stress physiological states such as hypertension, heart disease, diabetes, etc., RSV may potentially improve bone augmentation surgery in regenerative medicine.
View article: Photocurable GelMA Adhesives for Corneal Perforations
Photocurable GelMA Adhesives for Corneal Perforations Open
The current treatments for the management of corneal and scleral perforations include sutures and adhesives. While sutures are invasive, induce astigmatism and carry a risk of infection, cyanoacrylate glues are toxic, proinflammatory and f…
View article: Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repair
Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repair Open
Extracellular vesicles (EVs) have garnered growing attention as promising acellular tools for bone repair. Although EVs’ potential for bone regeneration has been shown, issues associated with their therapeutic potency and short half-life i…
View article: Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells
Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells Open
Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiat…
View article: A long-lasting guided bone regeneration membrane from sequentially functionalised photoactive atelocollagen
A long-lasting guided bone regeneration membrane from sequentially functionalised photoactive atelocollagen Open
The fast degradation of collagen-based membranes in the biological environment remains a critical challenge, resulting in underperforming Guided Bone Regeneration (GBR) therapy leading to compromised clinical results. Photoactive atelocoll…
View article: Development of a Bone-Mimetic 3D Printed Ti6Al4V Scaffold to Enhance Osteoblast-Derived Extracellular Vesicles’ Therapeutic Efficacy for Bone Regeneration
Development of a Bone-Mimetic 3D Printed Ti6Al4V Scaffold to Enhance Osteoblast-Derived Extracellular Vesicles’ Therapeutic Efficacy for Bone Regeneration Open
Extracellular Vesicles (EVs) are considered promising nanoscale therapeutics for bone regeneration. To date, EVs are typically procured from cells on 2D tissue culture plastic, an artificial environment that limits cell growth and does not…
View article: Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation
Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation Open
Extracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools, circumventing many of the limitations associated with cell‐based therapies. Epigenetic regulation through histone deacetylase (HDAC) inhibition h…
View article: The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells
The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells Open
The use of human dental pulp stromal cells (hDPSCs) has gained increasing attention as an alternative stem cell source for bone tissue engineering. The modification of the cells’ epigenetics has been found to play an important role in regu…
View article: Engineered Extracellular Vesicles: Tailored-Made Nanomaterials for Medical Applications
Engineered Extracellular Vesicles: Tailored-Made Nanomaterials for Medical Applications Open
Extracellular vesicles (EVs) are emerging as promising nanoscale therapeutics due to their intrinsic role as mediators of intercellular communication, regulating tissue development and homeostasis. The low immunogenicity and natural cell-t…