Khanh Q. Nguyen
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View article: Functional diversity of Arabidopsis late embryogenesis abundant proteins in response to changes in the physicochemical environment
Functional diversity of Arabidopsis late embryogenesis abundant proteins in response to changes in the physicochemical environment Open
Some desiccation-tolerant organisms accumulate intrinsically disordered proteins (IDPs), such as Late Embryogenesis Abundant (LEA) proteins, which help protect other proteins from inactivation and/or aggregation during desiccation. Like ot…
View article: Diagnostic Value of the Triglyceride-Glucose Index in Predicting Metabolic Syndrome in Women with Polycystic Ovary Syndrome
Diagnostic Value of the Triglyceride-Glucose Index in Predicting Metabolic Syndrome in Women with Polycystic Ovary Syndrome Open
Background: Polycystic ovary syndrome (PCOS) is associated with a high risk of metabolic syndrome (MetS), increasing cardiovascular complications. The Triglyceride-Glucose (TyG) index is a simple marker of insulin resistance, but its utili…
View article: Ganglion cyst in the tarsal tunnel
Ganglion cyst in the tarsal tunnel Open
View article: Electrical Properties of GaN/Ga2O3 P-N Junction Diodes: A TCAD Study
Electrical Properties of GaN/Ga2O3 P-N Junction Diodes: A TCAD Study Open
Ga2O3 and GaN are promising candidates for the fabrication of high power semiconductor devices due to their wide band-gap range, deteremined from 3.0 eV to 4.9 eV. Among these materials, the GaN/Ga2O3 P-N junction diode has an excellent pe…
View article: Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity
Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity Open
View article: Contents
Contents Open
View article: Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components Open
[This corrects the article DOI: 10.1371/journal.pgen.1010016.].
View article: Macroprolactin Molecular Heterogeneity and Variable Immunoassay Reactivity
Macroprolactin Molecular Heterogeneity and Variable Immunoassay Reactivity Open
Circulating prolactin (PRL) exhibits molecular heterogeneity the clinical significance of which is not known. Macroprolactin (mPRL) is widely reported, however, its heterogeneity is unknown. In addition to determining its molecular nature,…
View article: Cardiovascular response to small-molecule APJ activation
Cardiovascular response to small-molecule APJ activation Open
Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care. The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates ischemic injury, and has the potential to be a novel target to…
View article: Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols
Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols Open
Organic aerosols generated from the smoldering combustion of wood critically impact air quality and health for billions of people worldwide; yet, the links between the chemical components and the optical or biological effects of woodsmoke …
View article: SAT-456 Heterogeneity of Macroprolactin in Samples Suspected of False Hyperprolactinemia
SAT-456 Heterogeneity of Macroprolactin in Samples Suspected of False Hyperprolactinemia Open
Circulating prolactin (PRL) exists in several molecular forms with different biological and immunological activities, in some instances making PRL measurements and its diagnostic value unreliable. Macroprolactin (macroPRL), a 150 kDa molec…
View article: GTSD 2018 Index
GTSD 2018 Index Open
View article: Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration
Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration Open
Across phylogeny, glutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many complex behaviors. Perturbed synaptic and extrasynaptic Glu homeostasis in the human brain has been implicated in mul…
View article: A Newborn with Hypothermia and Hyperammonemia
A Newborn with Hypothermia and Hyperammonemia Open
A full-term small gestational age female infant was transferred to the NICU for hypothermia and seizure-like activity. In the first 10 h of life, the infant had difficulty feeding and developed mild hypothermia, which resolved after placin…
View article: Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy
Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy Open
View article: Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease
Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease Open
The principal projection neurons of the striatum are critically dependent on an afferent supply of brain derived neurotrophic factor (BDNF) for neurotrophic support. These neurons express TrkB, the cognate receptor for BDNF, which activate…
View article: Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway
Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway Open
The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidoni…