Marc Tollis
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View article: Structural Rearrangements and Selection Promote Phenotypic Evolution in <i>Anolis</i> Lizards
Structural Rearrangements and Selection Promote Phenotypic Evolution in <i>Anolis</i> Lizards Open
The genomic characteristics of adaptively radiated groups could contribute to their high species number and ecological disparity, by increasing their evolutionary potential. Here, we explored the genomic variation of Anolis lizards, focusi…
View article: Shrinking to bird size with dinosaur-level cancer defences: Evolution of cancer suppression over macroevolutionary time
Shrinking to bird size with dinosaur-level cancer defences: Evolution of cancer suppression over macroevolutionary time Open
Ubiquity of cancer across the tree of life yields opportunities to understand variation in cancer defences across species. Peto’s paradox, the finding that large-bodied species do not suffer from more cancer despite having more cells at ri…
View article: Recent Non-LTR Retrotransposon Activity Predicts Cancer Prevalence in Mammals
Recent Non-LTR Retrotransposon Activity Predicts Cancer Prevalence in Mammals Open
Non-long terminal repeat retrotransposons (nLTRs), including long and short interspersed nuclear elements (L1 and SINEs), are the most abundant and active mobile elements in mammals. NLTRs play critical mutagenic and regulatory roles durin…
View article: Origin and Early Evolution of Squamates and Their Kin: From Fossils to Genomes
Origin and Early Evolution of Squamates and Their Kin: From Fossils to Genomes Open
Squamates (lizards, including snakes) are the most diverse group of terrestrial vertebrates on Earth today and have an evolutionary history dating back to at least the Middle Triassic (ca. 242 Mya). Despite their vast taxonomic, morphologi…
View article: Anuran genome size evolution is driven by relatively recent retrotransposon activity and by life history
Anuran genome size evolution is driven by relatively recent retrotransposon activity and by life history Open
Background: Transposable elements (TEs), often referred to as ‘selfish genetic elements’, hijack their host’s genetic machinery to replicate themselves within the host genome, and are primary contributors to genome size in vertebrates. In …
View article: Paradoxical indeed
Paradoxical indeed Open
International audience
View article: Variable Gene Copy Number in Cancer-Related Pathways Is Associated With Cancer Prevalence Across Mammals
Variable Gene Copy Number in Cancer-Related Pathways Is Associated With Cancer Prevalence Across Mammals Open
Cancer is a disease of multicellularity, observed across the tree of life. In principle, animals with larger body sizes and longer lifespans should be at increased risk of developing cancer. However, there is no strong relationship between…
View article: Supplementary Figure S72 from Cancer Prevalence across Vertebrates
Supplementary Figure S72 from Cancer Prevalence across Vertebrates Open
High resolution cladogram from Figure 6 in the main text with the species' names as tip labels
View article: Supplementary Table S6 from Cancer Prevalence across Vertebrates
Supplementary Table S6 from Cancer Prevalence across Vertebrates Open
List of veterinarian diagnoses used as the data dictionary
View article: Supplementary Table S7 from Cancer Prevalence across Vertebrates
Supplementary Table S7 from Cancer Prevalence across Vertebrates Open
Results from the bootstrap analysis of different sample size cutoffs
View article: Supplementary Figure S41 from Cancer Prevalence across Vertebrates
Supplementary Figure S41 from Cancer Prevalence across Vertebrates Open
Multivariate PGLS regression analysis
View article: Supplementary Table S4 from Cancer Prevalence across Vertebrates
Supplementary Table S4 from Cancer Prevalence across Vertebrates Open
Phylogenetically controlled binomial regression results
View article: Supplementary Figures S1 - S69 from Cancer Prevalence across Vertebrates
Supplementary Figures S1 - S69 from Cancer Prevalence across Vertebrates Open
All of the PGLS regressions done with the exception of the multivariate analysis. The multivariate analysis is included as a separate file S41
View article: Supplementary Table S2 from Cancer Prevalence across Vertebrates
Supplementary Table S2 from Cancer Prevalence across Vertebrates Open
All data prevalence leaderboard
View article: Supplementary Table S8 from Cancer Prevalence across Vertebrates
Supplementary Table S8 from Cancer Prevalence across Vertebrates Open
Cell line collection and passage number information for the functional cell assays
View article: Supplementary Table S5 from Cancer Prevalence across Vertebrates
Supplementary Table S5 from Cancer Prevalence across Vertebrates Open
Model fitting results for the phenotype evolution models
View article: Supplementary Table S1 from Cancer Prevalence across Vertebrates
Supplementary Table S1 from Cancer Prevalence across Vertebrates Open
Mammal prevalence leaderboard
View article: Supplementary Table S3 from Cancer Prevalence across Vertebrates
Supplementary Table S3 from Cancer Prevalence across Vertebrates Open
Most common cancer types
View article: Supplementary Figure S70 from Cancer Prevalence across Vertebrates
Supplementary Figure S70 from Cancer Prevalence across Vertebrates Open
Analysis of our results with the outlier species removed
View article: Supplementary Figure S71 from Cancer Prevalence across Vertebrates
Supplementary Figure S71 from Cancer Prevalence across Vertebrates Open
Analysis our of our regression results with various data transformation techniques
View article: Data from Cancer Prevalence across Vertebrates
Data from Cancer Prevalence across Vertebrates Open
Cancer is pervasive across multicellular species, but what explains the differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades of tetrapods (amphibians, sauropsids, and mammals)…
View article: Cancer Prevalence across Vertebrates
Cancer Prevalence across Vertebrates Open
Cancer is pervasive across multicellular species, but what explains the differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades of tetrapods (amphibians, sauropsids, and mammals)…
View article: Differential Conservation and Loss of Chicken Repeat 1 (CR1) Retrotransposons in Squamates Reveal Lineage-Specific Genome Dynamics Across Reptiles
Differential Conservation and Loss of Chicken Repeat 1 (CR1) Retrotransposons in Squamates Reveal Lineage-Specific Genome Dynamics Across Reptiles Open
Transposable elements (TEs) are repetitive DNA sequences which create mutations and generate genetic diversity across the tree of life. In amniote vertebrates, TEs have been mainly studied in mammals and birds, whose genomes generally disp…
View article: Baleen whale microsatellite panel for individual identification and parentage assignment in Mysticeti
Baleen whale microsatellite panel for individual identification and parentage assignment in Mysticeti Open
DATA AVAILABILITY : Data and scripts are available in Zenodo https://zenodo.org/doi/10.5281/zenodo.10948827
View article: Differential Conservation and Loss of CR1 Retrotransposons in Squamates Reveals Lineage-Specific Genome Dynamics across Reptiles
Differential Conservation and Loss of CR1 Retrotransposons in Squamates Reveals Lineage-Specific Genome Dynamics across Reptiles Open
Transposable elements (TEs) are repetitive DNA sequences which create mutations and generate genetic diversity across the tree of life. In amniotic vertebrates, TEs have been mainly studied in mammals and birds, whose genomes generally dis…
View article: Life history traits and cancer prevalence in birds
Life history traits and cancer prevalence in birds Open
Background and objectives Cancer is a disease that affects nearly all multicellular life, including the broad and diverse taxa of Aves. While little is known about the factors that contribute to cancer risk across Aves, life history trade-…
View article: Genome Report: chromosome-scale genome assembly of the African spiny mouse (<i>Acomys cahirinus</i>)
Genome Report: chromosome-scale genome assembly of the African spiny mouse (<i>Acomys cahirinus</i>) Open
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality referenc…
View article: Cancer Prevalence Across Vertebrates
Cancer Prevalence Across Vertebrates Open
View article: The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order
The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order Open
Squamates include more than 11,000 extant species of lizards, snakes, and amphisbaenians, and display a dazzling diversity of phenotypes across their over 200-million-year evolutionary history on Earth. Here, we introduce and define squama…
View article: The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order
The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order Open
Squamates include 11,000 extant species of lizards, snakes, and amphisbaenians, and display a dazzling diversity of phenotypes across their over 200 million year evolutionary history on Earth. Here we introduce and define squamates…