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View article: Machine Learning Elucidates Population Density‐Dependent Morphological Phenotypic Changes of Macrophages
Machine Learning Elucidates Population Density‐Dependent Morphological Phenotypic Changes of Macrophages Open
Macrophages play a central role in modulating different biological and physiological events. The behaviors and functions of macrophages may be regulated by a host of factors, including their viability, proliferation rate, and population de…
View article: Supervised-Learning-Driven Interrogation of Organ-on-a-Chip Quality from Microscopy Images
Supervised-Learning-Driven Interrogation of Organ-on-a-Chip Quality from Microscopy Images Open
View article: Machine-Learning-Assisted Analysis of Patient Clinical Biomarkers to Improve Ovarian Cancer Diagnosis
Machine-Learning-Assisted Analysis of Patient Clinical Biomarkers to Improve Ovarian Cancer Diagnosis Open
The unavailability of accurate and reliable methods for early ovarian cancer detection represents a major gap in ovarian cancer diagnosis and management. The emergence and recent integration of machine learning with cancer diagnostic techn…
View article: Machine‐Learning‐Guided Analysis of Breast Tumor Malignancy Based on Nuclear Morphological Features
Machine‐Learning‐Guided Analysis of Breast Tumor Malignancy Based on Nuclear Morphological Features Open
Breast cancer remains one of the most life‐threatening diseases, with early and accurate diagnosis playing a crucial role in improving patient outcomes. Numerous cellular biomarkers, including the morphology of tumor cells, have been explo…
View article: Machine-learning-guided identification of protein secondary structures using spectral and structural descriptors
Machine-learning-guided identification of protein secondary structures using spectral and structural descriptors Open
We demonstrated the implementation of a machine-learning-mediated approach to identify the secondary structures of proteins based on different spectral and structural descriptors.
View article: Explainable ensemble learning to predict anisotropic nanomaterial band gap using atomic-scale structural descriptors
Explainable ensemble learning to predict anisotropic nanomaterial band gap using atomic-scale structural descriptors Open
We demonstrated the implementation of explainable ensemble learning to predict the electronic band gap of anisotropic nanomaterials based on atomic-scale structural descriptors.
View article: Microfluidic-assisted formulation of cell membrane-camouflaged anisotropic nanostructures
Microfluidic-assisted formulation of cell membrane-camouflaged anisotropic nanostructures Open
This work reports the development of a high-throughput microfluidic-based platform for the formulation of cell membrane-camouflaged anisotropic gold nanostructures with minimized phagocytic uptake and enhanced cancer cell targeting.
View article: Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers
Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers Open
With the increasing prevalence of infectious diseases caused by drug‐resistant bacteria, there is an urgent need to develop innovative therapies alternative to antibiotics. Among these alternatives, the aggregation‐induced emission (AIE) p…
View article: Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan
Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan Open
View article: Machine Learning‐Assisted Clustering of Nanoparticle‐Binding Peptides and Prediction of Their Properties
Machine Learning‐Assisted Clustering of Nanoparticle‐Binding Peptides and Prediction of Their Properties Open
Bioinspired and biomimetic nanostructures have attracted tremendous interest for theranostic and nanomedicine applications. Among the strategies employed to synthesize these nanostructures, surface functionalization and biomineralization o…
View article: Late-stage Peptide Modification and Cyclization via Maleimidation of C(7)-H Tryptophan
Late-stage Peptide Modification and Cyclization via Maleimidation of C(7)-H Tryptophan Open
Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to their excellent cell penetrability, stability, thermostability, and drug-like properties. However, the currently available facile methodologies for…
View article: Advances in Surface Enhanced Raman Spectroscopy for <i>in Vivo</i> Imaging in Oncology
Advances in Surface Enhanced Raman Spectroscopy for <i>in Vivo</i> Imaging in Oncology Open
In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, pr…
View article: Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications
Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications Open
Surface-enhanced Raman spectroscopy (SERS) nanotags hold a unique place among bioimaging contrast agents due to their fingerprint-like spectra, which provide one of the highest degrees of detection specificity. However, in order to achieve…
View article: CCDC 1915893: Experimental Crystal Structure Determination
CCDC 1915893: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1875077: Experimental Crystal Structure Determination
CCDC 1875077: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1915891: Experimental Crystal Structure Determination
CCDC 1915891: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1875388: Experimental Crystal Structure Determination
CCDC 1875388: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1875082: Experimental Crystal Structure Determination
CCDC 1875082: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Photodynamic Therapy: Bacterium‐Templated Polymer for Self‐Selective Ablation of Multidrug‐Resistant Bacteria (Adv. Funct. Mater. 31/2020)
Photodynamic Therapy: Bacterium‐Templated Polymer for Self‐Selective Ablation of Multidrug‐Resistant Bacteria (Adv. Funct. Mater. 31/2020) Open
In article number 2001338, Bin Liu and co-workers report a material platform that exploits bacteria as a template to synthesize polymers with aggregation-induced emission characteristics. The bacterium-templated polymer shows very weak flu…
View article: AIEgen-coupled upconversion nanoparticles eradicate solid tumors through dual-mode ROS activation
AIEgen-coupled upconversion nanoparticles eradicate solid tumors through dual-mode ROS activation Open
Integration of AIEgens with upconversion nanoparticles inhibits tumor recurrence and metastasis.
View article: Catalyst: Aggregation-Induced Emission—How Far Have We Come, and Where Are We Going Next?
Catalyst: Aggregation-Induced Emission—How Far Have We Come, and Where Are We Going Next? Open
View article: Hydrostatic pressure promotes endothelial tube formation through aquaporin 1 and Ras-ERK signaling
Hydrostatic pressure promotes endothelial tube formation through aquaporin 1 and Ras-ERK signaling Open
Vascular tubulogenesis is tightly linked with physiological and pathological events in the living body. Endothelial cells (ECs), which are constantly exposed to hemodynamic forces, play a key role in tubulogenesis. Hydrostatic pressure in …
View article: Enhancing the performance of pure organic room-temperature phosphorescent luminophores
Enhancing the performance of pure organic room-temperature phosphorescent luminophores Open
Once considered the exclusive property of metal complexes, the phenomenon of room-temperature phosphorescence (RTP) has been increasingly realized in pure organic luminophores recently. Using precise molecular design and synthetic approach…
View article: Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of Hepatocellular Carcinoma
Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of Hepatocellular Carcinoma Open
Photosensitizer (PS) serves as the central element of photodynamic therapy (PDT). The use of common nanoparticles (NPs) for PDT has typically been rendered less effective by the undesirable aggregation-caused quenching (ACQ) effect, result…
View article: Biological Imaging: Recent Advances of Optical Imaging in the Second Near‐Infrared Window (Adv. Mater. 47/2018)
Biological Imaging: Recent Advances of Optical Imaging in the Second Near‐Infrared Window (Adv. Mater. 47/2018) Open
In article number 1802394, Bin Liu and co-workers highlight the recent development of optical imaging in the second near-infrared (NIR-II) window. The importance of NIR-II imaging, as well as the development of exogenous contrast agents in…
View article: Polymerization-Enhanced Photosensitization
Polymerization-Enhanced Photosensitization Open
View article: Antibacterial Therapy: Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy (Adv. Mater. 18/2018)
Antibacterial Therapy: Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy (Adv. Mater. 18/2018) Open
In article number 1706831, Deling Kong, Bin Liu, and co-workers report a new in vivo antibacterial strategy. With the help of a metal–organic framework, a functionalized amino acid, and photosensitizer nanoparticles with aggregation-induce…
View article: Label-free extraction of extracellular vesicles using centrifugal microfluidics
Label-free extraction of extracellular vesicles using centrifugal microfluidics Open
Extracellular vesicles (EVs) play an important role as active messengers in intercellular communication and distant microenvironment modeling. Increasingly, these EVs are recognized as important biomarkers for clinical diagnostics. However…
View article: Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process
Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process Open
Two AIEgens are designed for tracking mitochondria and lysosomes with different emission colors using single wavelength excitation to visualize the mitophagy process.
View article: Paper-based MoS2 nanosheet-mediated FRET aptasensor for rapid malaria diagnosis
Paper-based MoS2 nanosheet-mediated FRET aptasensor for rapid malaria diagnosis Open