Kensuke Nishimiya
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View article: Fractal analysis of dynamic stress myocardial CT perfusion decouples diagnostic accuracy for obstructive coronary artery disease from remote flow
Fractal analysis of dynamic stress myocardial CT perfusion decouples diagnostic accuracy for obstructive coronary artery disease from remote flow Open
Purpose In patients with reduced remote flow, dynamic stress CT perfusion imaging (CTP) has limited utility for detecting obstructive coronary artery disease (CAD). We compared fractal analysis, a descriptor of macro- and microvascular isc…
View article: Comprehensive full-vessel segmentation and volumetric plaque quantification for intracoronary optical coherence tomography using deep learning
Comprehensive full-vessel segmentation and volumetric plaque quantification for intracoronary optical coherence tomography using deep learning Open
Aims Intracoronary optical coherence tomography (OCT) provides detailed information on coronary lesions, but interpretation of OCT images is time-consuming and subject to interobserver variability. The aim of this study was to develop and …
View article: Clinical Characteristics and Outcome of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries in Japan: Insights From the Miyagi Acute Myocardial Infarction Registry Study
Clinical Characteristics and Outcome of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries in Japan: Insights From the Miyagi Acute Myocardial Infarction Registry Study Open
Background Clinical characteristics and outcomes of patients with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) are not fully understood, particularly in Japan. Methods and Results We enrolled a total of 8881 pa…
View article: The outcomes of electronic personal health records in patients with heart failure or coronary artery disease
The outcomes of electronic personal health records in patients with heart failure or coronary artery disease Open
Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementa…
View article: Imaging human coronary cholesterol/urate crystals with cross-polarized micro-optical coherence tomography
Imaging human coronary cholesterol/urate crystals with cross-polarized micro-optical coherence tomography Open
Introduction Birefringent crystals such as monosodium-urate (MSU) and cholesterol crystals (CC) likely contribute to the progression of coronary artery disease (CAD) due to their potential to exacerbate inflammation through inflammatory cy…
View article: Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases
Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases Open
The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose inta…
View article: A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris
A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris Open
Background Despite the advances in the treatment of cardiovascular diseases, effective treatment remains to be established to improve the quality of life and prognosis of patients with chronic coronary syndromes. This study was aimed to ev…
View article: Mechanisms of Coronary Artery Spasm
Mechanisms of Coronary Artery Spasm Open
Recent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to corona…
View article: Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT
Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT Open
Objectives Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valv…
View article: A Randomized, Double-blind, Placebo-controlled Pilot Trial of Low-intensity Pulsed Ultrasound Therapy for Refractory Angina Pectoris
A Randomized, Double-blind, Placebo-controlled Pilot Trial of Low-intensity Pulsed Ultrasound Therapy for Refractory Angina Pectoris Open
Despite the advances in the treatment of cardiovascular diseases, effective treatment remains to be established to improve the quality of life of patients with chronic coronary syndrome. The aim of this study was to evaluate the effectiven…
View article: The influence of COVID-19 pandemic on management of acute myocardial infarction in Japan; Insight from the Miyagi AMI Registry Study
The influence of COVID-19 pandemic on management of acute myocardial infarction in Japan; Insight from the Miyagi AMI Registry Study Open
View article: Histopathological correlation of near infrared autofluorescence in human cadaver coronary arteries
Histopathological correlation of near infrared autofluorescence in human cadaver coronary arteries Open
View article: Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo
Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo Open
Backgrounds We demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of drug-eluting stent (DES)-induced coronary hyperconstricting responses in pigs in vivo. However, no therapy is yet available to …
View article: Pathophysiology and Diagnosis of Coronary Functional Abnormalities
Pathophysiology and Diagnosis of Coronary Functional Abnormalities Open
Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary …
View article: Micro Optical Coherence Tomography for Coronary Imaging
Micro Optical Coherence Tomography for Coronary Imaging Open
Intravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque…
View article: Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA
Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA Open
These results provide the first evidence that there are important prognostic links between coronary morphologies (evaluated by optical coherence tomography) and coronary functional abnormalities in patients with INOCA, indicating the impor…
View article: 1. Anti-thrombotic Therapy for Acute and Chronic Coronary Syndrome
1. Anti-thrombotic Therapy for Acute and Chronic Coronary Syndrome Open
高齢化の進む我が国では，出血リスクの高い患者への対応が求められる．2020年，日本循環器学会ガイドラインが改訂され，「冠動脈疾患患者における抗血栓療法」が発表された．ステント血栓症に対する抗血小板薬2剤併用療法（dual antiplatelet therapy：DAPT）期間の短縮やde-escalation，さらに，安定冠動脈疾患を合併した心房細動症例に対する抗凝固薬単剤療法等less is moreレジメンに抗血栓療法のコンセプトは転換してきている．
View article: Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease
Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease Open
BACKGROUND Stable coronary artery disease is caused by a variable combination of organic coronary stenosis and functional coronary abnormalities, such as coronary artery spasm. Thus, we examined the clinical importance of comorbid signific…
View article: Recent Advances in Vascular Imaging
Recent Advances in Vascular Imaging Open
Recent advances in vascular imaging have enabled us to uncover the underlying mechanisms of vascular diseases both ex vivo and in vivo. In the past decade, efforts have been made to establish various methodologies for evaluation of atheros…
View article: 3D cellular-resolution imaging in arteries using few-mode interferometry
3D cellular-resolution imaging in arteries using few-mode interferometry Open
View article: Micro-Optical Coherence Tomography for Endothelial Cell Visualization in the Coronary Arteries
Micro-Optical Coherence Tomography for Endothelial Cell Visualization in the Coronary Arteries Open
View article: Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney–Brain–Heart Axis
Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney–Brain–Heart Axis Open
Objective— Drug-eluting stent–induced coronary hyperconstricting responses remain an important issue. The adventitia harbors a variety of components that potently modulate vascular tone, including sympathetic nerve fibers (SNF) and vasa va…
View article: Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent–Induced Coronary Hyperconstricting Responses in Pigs
Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent–Induced Coronary Hyperconstricting Responses in Pigs Open
Objective— Although coronary perivascular adipose tissue (PVAT) may play important roles as a source of inflammation, the association of coronary PVAT inflammation and coronary hyperconstricting responses remains to be examined. We address…
View article: Age-Specific Trends in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction Over 30 Years in Japan — Report From the Miyagi AMI Registry Study —
Age-Specific Trends in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction Over 30 Years in Japan — Report From the Miyagi AMI Registry Study — Open
These results provide the novel findings that the incidence of AMI has been increasing in younger populations and decreasing in the elderly, and that improvement in the in-hospital mortality of AMI may have reached a plateau in all age gro…
View article: Viewpoint: Recent Advances in Intracoronary Imaging for Vasa Vasorum Visualisation
Viewpoint: Recent Advances in Intracoronary Imaging for Vasa Vasorum Visualisation Open
The coronary adventitia harbours the vasa vasorum (VV), which has a diameter of 50–300 μm and plays an important role as a network of nutrient blood vessels to the arterial wall. The VV is thought to be involved in the development of coron…
View article: Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries
Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries Open
Plasma concentration of serotonin may be a novel biomarker for CMD in patients with angina and unobstructive coronary arteries.
View article: Serious Hypocalcemia After Withdrawal of Vitamin D Analog in Bedridden Nonagenarians with Previous Thyroidectomy: A Report of Two Cases
Serious Hypocalcemia After Withdrawal of Vitamin D Analog in Bedridden Nonagenarians with Previous Thyroidectomy: A Report of Two Cases Open
Supplementation with vitamin D and its analogs are beneficial for the treatment of geriatric osteoporosis and prevents elderly adults from becoming bedridden,1 but its benefit for elderly adults who are already bedridden is limited.2 In ad…
View article: Focal Vasa Vasorum Formation in Patients With Focal Coronary Vasospasm – An Optical Frequency Domain Imaging Study –
Focal Vasa Vasorum Formation in Patients With Focal Coronary Vasospasm – An Optical Frequency Domain Imaging Study – Open
14% of VSA patients
View article: CONTENTS OF VOLUME 80, 2016
CONTENTS OF VOLUME 80, 2016 Open
View article: Overview of the 80<sup>th</sup> Annual Scientific Meeting of the Japanese Circulation Society – The Past, Present and Future of Cardiovascular Medicine in Japan – – The 5<sup>th</sup> Anniversary of the Great East Japan Earthquake –
Overview of the 80<sup>th</sup> Annual Scientific Meeting of the Japanese Circulation Society – The Past, Present and Future of Cardiovascular Medicine in Japan – – The 5<sup>th</sup> Anniversary of the Great East Japan Earthquake – Open
The 80(th)Annual Scientific Meeting of the Japanese Circulation Society was held in Sendai, Japan, on March 18-20, 2016, which coincided with the 5(th)anniversary of the Great East Japan Earthquake that hit the Tohoku area on March 11, 201…