Explanipedia

Machine Learning and Artificial Intelligence in Clinical Medicine—Trends, Impact, and Future Directions Open

Carlos Escobar Cervantes, Kent Doi · 2025

Over the past decade, the integration of machine learning (ML) and artificial intelligence (AI) into clinical medicine has accelerated dramatically, reshaping the ways in which clinicians collect, analyze, and interpret health data [...]

Current Status of Continuous Renal Replacement Therapy in Japanese Intensive Care Units: A Multicenter Retrospective Observational Study Open

Hidehiko Nakano, Ryota Inokuchi, Yutaro Inoue, Motohiro Sekino, Yasuyuki Kakihana , et al. · 2025

Introduction: Continuous renal replacement therapy (CRRT) is often performed for critically ill patients in intensive care units (ICUs), but its optimal indication and settings have yet to be determined. Thus, we aimed to describe the curr…

Early major adverse kidney events after lung transplantation: risk of chronic kidney disease and prognostic impact Open

Yoshihisa Shimada, Chihiro Konoeda, Yue Cong, Masaaki Nagano, Keita Nakao , et al. · 2025

Objective Renal dysfunction, including acute kidney injury (AKI) and chronic kidney disease (CKD), is a major complication following lung transplantation (LT) and is associated with increased morbidity and mortality. This study aims to eva…

Endotoxaemia in childhood-onset systemic lupus erythematosus induces low-density granulocytes and extracellular traps of innate immune cells Open

Wilasinee Saisorn, Pornpimol Phuengmaung, Chanunya Santiworakul, Kent Doi, Pornpimol Rianthavorn , et al. · 2025

Background Endotoxaemia without infection in lupus is mentioned with the inconclusive clinical importance. Methods With endotoxaemia and lupus activity (Systemic Lupus Erythematosus Disease Activity Index 2000 score), 46 patients with chil…

Mortality of severe pneumonia treated with methylprednisolone versus hydrocortisone: a propensity-matched analysis Open

Takuya Sato, Yusuke Sasabuchi, Ryota Inokuchi, Shotaro Aso, Hideo Yasunaga , et al. · 2025

Background Corticosteroids improve the outcomes of severe pneumonia; however, the most effective type remains unknown. In this study, we compared the mortality rates of patients with severe pneumonia who were treated with methylprednisolon…

A phase 3 study of ravulizumab to protect patients with chronic kidney disease from cardiac surgery-associated acute kidney injury and major adverse kidney events (ARTEMIS) Open

Marlies Ostermann, David Corteville, Kent Doi, Jay L. Koyner, André Lamy , et al. · 2025

Background Cardiac procedures, particularly those requiring cardiopulmonary bypass (CPB), are associated with the development of cardiac surgery-associated acute kidney injury (CSA-AKI). Development of CSA-AKI occurs as a result of inflamm…

Dynamic intra-abdominal organ volume changes in patients with sepsis Open

Shunsuke Tagami, Tamae Wada, Ryota Inokuchi, Wataru Gonoi, Kent Doi · 2025

Severe Pneumonia Due to Streptococcal Toxic Shock Syndrome in a Patient Positive for Influenza Virus Antigen: A Case Report Open

Katsuhiko Nagai, Ryota Inokuchi, Hiroyuki Nakano, Toshifumi Asada, Ryohei Horie , et al. · 2025

Since the onset of the COVID-19 pandemic, the incidence of streptococcal toxic shock syndrome (STSS) has increased. Additionally, complications involving influenza virus infections in STSS cases have been reported more frequently than in t…

Life-threatening asphyxiation owing to a giant vocal cord polyp: Case report Open

Keisuke Nyunoya, Takahiro Hiruma, Ichiro Hirayama, Hitomi Nakamura, Yuri Endo , et al. · 2025

Various causes of airway obstruction have been reported, such as foreign substances or tumours. However, few studies have reported sudden asphyxiation owing to causes other than foreign substances. We report the case of a 59-year-old woman…

Renal replacement therapy modalities and techniques in intensive care units: An international survey Open

Céline Monard, Arnaud Marel, Michael Joannidis, Marlies Ostermann, Zhiyong Peng , et al. · 2025

This international survey underscores the large diversity in RRT practices wordlwide, as well as heterogeneity in beliefs and preferences among intensivists. These data highlight the need for robust comparative trials to identify the optim…

Ventricular Tachycardia Ablation Using Map Merge Capable of Integrating Multiple Sessions Open

Jun Yokota, Katsuhito Fujiu, Kent Doi, Norihiko Takeda · 2025

This case report presents a novel approach for ventricular tachycardia (VT) ablation in a patient with cardiac sarcoidosis, utilizing the Map Merge function of the CARTO 3 system to integrate mapping data from multiple ablation sessions. A…

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024 Open

Nobuaki Shime, Taka-aki Nakada, Tomoaki Yatabe, Kazuma Yamakawa, Yoshitaka Aoki , et al. · 2025

The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. …

Influence of Baseline Kidney Function on Patient and Kidney Outcomes in Patients with COVID-19: A Multi-National Observational Study Open

Harin Rhee, Etienne Macedo, Gary Cutter, Eric Judd, Sreejith Parameswaran , et al. · 2025

Background/Objectives: Acute kidney injury (AKI) is a common complication of coronavirus disease-19 (COVID-19), but the impact of baseline kidney function and care processes on outcomes is not well understood. We hypothesized that baseline…

Granulocyte and Monocyte Adsorption Therapy in Patients With Sepsis: A Feasibility Study Open

Osamu Nishida, Tomoyuki Nakamura, Taka‐aki Nakada, Gaku Takahashi, Yoshiki Masuda , et al. · 2025

Background The pathogenesis of sepsis is thought to be linked to a dysregulated immune response, particularly that involving neutrophils. We have developed a granulocyte adsorption column as a “decoy organ,” which relocates the massive inf…

Takotsubo Syndrome Following Status Epilepticus in a Heart Transplant Recipient: A Case Report Open

Takeshi Shikama, Mio Shikama, Naoki Hayase, Kent Doi · 2025

Introduction: Takotsubo syndrome (TTS) expresses transient wall motion abnormality of the left ventricle, reportedly induced by sympathetic overstimulation. Takotsubo syndrome is unlikely to be included in the differential diagnosis of hea…

Crayon ingestion Open

Kyoji Noda, Tomoki Wada, Ryohei Horie, Toshifumi Asada, Ryota Inokuchi , et al. · 2025

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024 Open

Nobuaki Shime, Taka‐aki Nakada, Tomoaki Yatabe, Kazuma Yamakawa, Yoshitaka Aoki , et al. · 2025

The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J‐SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. …

Impact of COVID‐19 on resuscitation after hospital arrival for patients with out‐of‐hospital cardiac arrest: An interrupted time series analysis Open

Takuya Sato, Hiroyuki Ohbe, Yusuke Sasabuchi, Ryota Inokuchi, Hideo Yasunaga , et al. · 2025

Background In this study, we aimed to determine the effects of the coronavirus disease 2019 (COVID‐19) pandemic on in‐hospital cardiopulmonary resuscitation (CPR) in patients with out‐of‐hospital cardiac arrest (OHCA). Methods and Results …

Higher Processed Blood Volume of Granulocyte and Monocyte Adsorption Apheresis Ameliorates Long-Term Disease Activity in Ulcerative Colitis Patients Open

Yoshifumi Hamasaki, Ryo Matsuura, Takahide Shinagawa, Soichiro Ishihara, Sozaburo Ihara , et al. · 2024

Greater processed blood volume of GMA per patient body weight may be associated with a lower 1-year exacerbation rate in UC patients.

Abstracts of the 2nd International Electronic Conference on Clinical Medicine (ECCM 2024) Open

Emmanuel Andrès, Kent Doi · 2024

The 2nd International Electronic Conference on Clinical Medicine: Chronic Diseases—Current State and Future Trends (ECCM 2024) was organized by MDPI and MDPI Journal of Clinical Medicine and took place online from 13 to 15 November …

Reduction Rate of Uric Acid in Blood during Continuous Renal Replacement Therapy for Acute Kidney Injury: A Multicenter Retrospective Observational Study Open

Yutaro Inoue, Ryota Inokuchi, Hidehiko Nakano, Yoshiki Masuda, Osamu Nishida , et al. · 2024

Introduction: Continuous renal replacement therapy (CRRT) eliminates these small solutes with equal efficacy under the same conditions. However, variations in the reduction rates of these solutes observed in patients with CRRT are likely i…

Consensus statements for the establishment of medical intensive care in low-resource settings: international study using modified Delphi methodology Open

Peđja Kovačević, Jadranka Vidović, Boris Tomić, Jihad Mallat, Ali Ait Hssain , et al. · 2024

Delphi process identified a set of consensus-based statements on how to create a sustainable patient-centered medical intensive care in LRS.

Association Between IV Contrast Media Exposure and Acute Kidney Injury in Patients Requiring Emergency Admission: A Nationwide Observational Study in Japan Open

Ryo Hisamune, Kazuma Yamakawa, Yutaka Umemura, Noritaka Ushio, Katsunori Mochizuki , et al. · 2024

OBJECTIVE: This study aimed to elucidate the association between IV contrast media CT and acute kidney injury (AKI) and in-hospital mortality among patients requiring emergency admission. DESIGN: In this retrospective observational study, …

Increased white blood cell count is associated with an increased demand for unfractionated heparin during veno-arterial extracorporeal oxygenation in lung transplantation Open

Koichi Kashiwa, Hideo Kurosawa, Kazuki Fujishiro, Hitoshi Kubo, Ryota Inokuchi , et al. · 2024

Background : This retrospective observational study aimed to examine whether clinical inflammatory parameters were associated with the requirement dosage of unfractionated heparin (UFH) to maintain the range of ACT in veno-arterial extraco…

Improving long-term outcome of acute kidney injury Open

Kent Doi · 2024

急性腎障害(acute kidney injury, AKI)は血清クレアチニン濃度上昇と尿量減少により診断され,幅広い疾患スペクトラムを有する症候群である。患者背景と医療の進歩により,急性腎不全(acute renal failure, ARF)と呼ばれていた治療対象に変化が生じ,新たにAKIという概念が提唱されて20年近くが経過した。その後,AKIの中長期的な予後が慢性腎臓病(chronic kidney disease, CKD)への移行という形で注目されるようになり…

Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study Open

Ryohei Horie, Naoki Hayase, Toshifumi Asada, Miyuki Yamamoto, Takehiro Matsubara , et al. · 2024

Background The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients. Methods This is a single-center, prospective observational …

Heterogeneity in the definition of major adverse kidney events: a scoping review Open

Akinori Maeda, Ryota Inokuchi, Rinaldo Bellomo, Kent Doi · 2024

In Pursuit of Transformational Clinical Solutions Open

Kent Doi · 2024

It gives me great pleasure to introduce myself as the new Co-Editor-in-Chief of the Journal of Clinical Medicine (JCM) [...]

V. Clinical and Pathobiological Features of Kidney-lung Interaction Open

Yohei Komaru, Kent Doi · 2024

How Do We Bridge the Gap Between Animal Models of Sepsis and Patients? Open

Naoki Hayase, Kent Doi · 2024

Sepsis accounts for more than 50% of hospital deaths in the United States, and the cost of sepsis treatment ranks at the top of the list.1 Unfortunately, we do not have definitive therapeutic strategies for sepsis beyond supportive care. A…

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