Kazuhiro Kimura
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View article: Intravitreal aflibercept 8 mg in patients from Japan with diabetic macular edema: 48-week subgroup analysis of the PHOTON trial
Intravitreal aflibercept 8 mg in patients from Japan with diabetic macular edema: 48-week subgroup analysis of the PHOTON trial Open
Purpose In the pivotal PHOTON trial of patients with diabetic macular edema (DME), aflibercept 8 mg administered every 12 (8q12) and 16 (8q16) weeks demonstrated similar visual and anatomic outcomes with no new safety signals to aflibercep…
View article: A novel risk score model for predicting mortality in heart failure with preserved ejection fraction: Insights from the CURE-HF Registry–ApHAC score
A novel risk score model for predicting mortality in heart failure with preserved ejection fraction: Insights from the CURE-HF Registry–ApHAC score Open
Aims To create a simple risk score model to predict post-discharge mortality in patients with heart failure with preserved ejection fraction (HFpEF) after treatment for acute decompensated heart failure (HF). Methods and results This was a…
View article: Bilateral Macular Coloboma With Eccentric Fixation Confirmed by Microperimetry: A Case Report
Bilateral Macular Coloboma With Eccentric Fixation Confirmed by Microperimetry: A Case Report Open
The purpose of this report is to describe a case of bilateral macular coloboma with eccentric fixation confirmed by microperimetry. A 21-year-old Vietnamese woman presented with bilateral vision loss and was diagnosed with bilateral macula…
View article: Identification of Metabolomics Profile in Elderly Patients at the End Stage of Heart Failure
Identification of Metabolomics Profile in Elderly Patients at the End Stage of Heart Failure Open
Carnitine, symmetric dimethylarginine, urea, and tryptophan appear to be critical biomarkers for monitoring terminal stages in HF. Our results suggest that myocardial energy metabolism and renal dysfunction are associated with changes in t…
View article: Factors that contribute to loss to follow-up in the medium term after initiation of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in Japanese patients
Factors that contribute to loss to follow-up in the medium term after initiation of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in Japanese patients Open
Purpose To identify time-specific factors associated with loss to follow-up (LTFU) in the early to medium term after initiating anti-vascular endothelial growth factor (VEGF) treatment in patients with neovascular age-related macular degen…
View article: MXene‐Integrated Contact Lens: A Breakthrough in Wearable Eye Protection and Healthcare
MXene‐Integrated Contact Lens: A Breakthrough in Wearable Eye Protection and Healthcare Open
Smart contact lenses with electronic circuits are rapidly advancing for health monitoring and sensing applications, but concerns over electromagnetic (EM) radiation exposure remain. As these devices are near commercialization, protecting t…
View article: Clinical Profile and Prognosis of Patients With Acute Decompensated Heart Failure Who Met the Obesity-Related Eligibility for Subcutaneous Semaglutide ― Findings From the CURE-HF Registry ―
Clinical Profile and Prognosis of Patients With Acute Decompensated Heart Failure Who Met the Obesity-Related Eligibility for Subcutaneous Semaglutide ― Findings From the CURE-HF Registry ― Open
Almost 7.2% of the ADHF patients were semaglutide-eligible. Our findings did not affirm the "obesity paradox" in semaglutide-eligible HF patients after adjusting for demographic factors.
View article: Clinical Utility of the HELT-E<sub>2</sub>S<sub>2</sub> Score for Risk Stratification in Patients with Acute Decompensated Heart Failure: Insights from the CURE-HF Registry
Clinical Utility of the HELT-E<sub>2</sub>S<sub>2</sub> Score for Risk Stratification in Patients with Acute Decompensated Heart Failure: Insights from the CURE-HF Registry Open
Objective The HELT-E2S2 score is a novel risk assessment tool for ischemic stroke in patients with atrial fibrillation. We explored the prognostic impact of the HELT-E2S2 score on cardiovascular outcomes in patients with heart failure (HF)…
View article: The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study
The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study Open
Purpose: To elucidate pathogen-specific seasonal patterns in infectious keratitis through a comprehensive long-term analysis of microbiologically proven cases in a Japanese tertiary care center. Methods: This retrospective study analyzed 5…
View article: ALTERATION OF TREATMENT CHOICES AND THE VISUAL PROGNOSIS FOR DIABETIC MACULAR EDEMA IN THE ERA OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR DRUGS
ALTERATION OF TREATMENT CHOICES AND THE VISUAL PROGNOSIS FOR DIABETIC MACULAR EDEMA IN THE ERA OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR DRUGS Open
Purpose: To assess the real-world outcome of best-corrected visual acuity after 2-year intervention for treatment-naive diabetic macular edema since the approval of anti-vascular endothelial growth factor therapy. Methods: A total of 1,780…
View article: The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity
The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity Open
Inflammation-induced choroidal neovascularization followed by the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) is a cause of neovascular age-related macular degeneration (nAMD). RPE-derived myofibrobla…
View article: HIF-1α–dependent regulation of angiogenic factor expression in Müller cells by mechanical stimulation
HIF-1α–dependent regulation of angiogenic factor expression in Müller cells by mechanical stimulation Open
Mechanical stress regulates various biological processes in cells, tissues, and organs as well as contributes to the pathogenesis of various diseases. The retina is subjected to mechanical stress imposed by intraocular pressure as well as …
View article: Prognostic Impact of the Ratio of Hemoglobin to Red Blood Cell Distribution Width in Patients after Acute Decompensated Heart Failure
Prognostic Impact of the Ratio of Hemoglobin to Red Blood Cell Distribution Width in Patients after Acute Decompensated Heart Failure Open
Objective The ratio of hemoglobin to red blood cell distribution width (Hb/RDW) is a simple and readily available tool associated with adverse outcomes in chronic heart failure (HF). However, the association between the Hb/RDW ratio and mo…
View article: Outcomes of Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty and Pulmonary Endarterectomy
Outcomes of Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty and Pulmonary Endarterectomy Open
BPA strategy was more frequently chosen in older patients compared with PEA strategy and showed acceptable outcomes for efficacy with greater advantage for improvement in renal function. (Multicenter registry of chronic thromboembolic pulm…
View article: Major depressive disorder after heart transplantation with partial response to antidepressant therapy and remission with aripiprazole augmentation: A case report
Major depressive disorder after heart transplantation with partial response to antidepressant therapy and remission with aripiprazole augmentation: A case report Open
The incidence of major depressive disorder (MDD) after heart transplantation is high; however, there are no reports on treatment options when antidepressant therapy fails to improve the condition. We herein report on the case of a woman wi…
View article: Treatment of Failure of Macular Hole Closure due to Post-Vitrectomy Macular Edema Using Sub-Tenon Triamcinolone Acetonide Injection: A Case Report
Treatment of Failure of Macular Hole Closure due to Post-Vitrectomy Macular Edema Using Sub-Tenon Triamcinolone Acetonide Injection: A Case Report Open
Introduction: Post-vitrectomy cystoid macular edema (CME) can lead to failure of macular hole (MH) closure. We report 2 cases of failure of MH closure due to post-vitrectomy CME, which were successfully treated using sub-Tenon triamcinolon…
View article: Investigating the seasonality of infectious keratitis by pathogen: A retrospective study
Investigating the seasonality of infectious keratitis by pathogen: A retrospective study Open
This study aimed to investigate the seasonal trends in infectious keratitis by assessing the month of onset and causative microorganisms. Five hundred consecutive cases of infectious keratitis that were diagnosed and treated by a corneal s…
View article: HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells
HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells Open
Mechanical stimulation as a mimic of drusen formation in the eye increases the expression of angiogenic factors in retinal pigment epithelial (RPE) cells, but the underlying molecular mechanisms remain unclear. We investigated and characte…
View article: SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation
SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation Open
The potential risks associated with organs from COVID-19-infected donors were unclear. To determine the SARS-CoV-2 infection status of corneas transplanted during the COVID-19 pandemic, we performed a polymerase chain reaction (PCR) using …
View article: Association of Early Tolvaptan Treatment and Length of In Hospital Stay in Elderly Patients with Acute Decompensated Heart Failure
Association of Early Tolvaptan Treatment and Length of In Hospital Stay in Elderly Patients with Acute Decompensated Heart Failure Open
Early tolvaptan administration was associated with reduced length of hospital stay in elderly HF.
View article: SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation
SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation Open
The potential risks associated with organs from COVID-19-infected donors were unclear. To determine the SARS-CoV-2 infection status of corneas transplanted during the COVID-19 pandemic, we performed a polymerase chain reaction (PCR) using …
View article: The Rax homeoprotein in Müller glial cells is required for homeostasis maintenance of the postnatal mouse retina
The Rax homeoprotein in Müller glial cells is required for homeostasis maintenance of the postnatal mouse retina Open
Müller glial cells, which are the most predominant glial subtype in the retina, play multiple important roles, including the maintenance of structural integrity, homeostasis, and physiological functions of the retina. We have previously fo…
View article: Dietary intake of whale oil containing ω-3 long-chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice
Dietary intake of whale oil containing ω-3 long-chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice Open
Dietary ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) protect against age-related macular degeneration (AMD). We here examined the effects of whale oil, which contains ω-3 LCPUFAs, in a mouse model of AMD. Mice were fed either a die…
View article: Combination of blockade of endothelin signalling and compensation of IGF1 expression confers protective effects on degenerating retina
Combination of blockade of endothelin signalling and compensation of IGF1 expression confers protective effects on degenerating retina Open
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction, from which 1 in 4,000 people suffer worldwide. This disease is currently assumed to be intractable because effective therapeutic methods have not been e…
View article: Prognostic Impact of Hyperpolypharmacy Due to Noncardiovascular Medications in Patients After Acute Decompensated Heart Failure ― Insights From the Clue of Risk Stratification in the Elderly Patients With Heart Failure (CURE-HF) Registry ―
Prognostic Impact of Hyperpolypharmacy Due to Noncardiovascular Medications in Patients After Acute Decompensated Heart Failure ― Insights From the Clue of Risk Stratification in the Elderly Patients With Heart Failure (CURE-HF) Registry ― Open
Hyperpolypharmacy due to non-CV medications was associated with an elevated risk of death in patients after ADHF, suggesting the importance of a regular review of the prescribed drugs including non-CV medications.
View article: Initial Triple Combination Therapy Including Intravenous Prostaglandin I<sub>2</sub> for the Treatment of Patients with Severe Pulmonary Arterial Hypertension
Initial Triple Combination Therapy Including Intravenous Prostaglandin I<sub>2</sub> for the Treatment of Patients with Severe Pulmonary Arterial Hypertension Open
Upfront combination therapy including intravenous prostaglandin I2 (PGI2-IV) is recognized as the most appropriate treatment for patients with severe pulmonary arterial hypertension (PAH). This retrospective study aimed to determine reason…