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View article: Recognizing Coagulation Disorders in Sepsis in the Emergency Room: A Narrative Review
Recognizing Coagulation Disorders in Sepsis in the Emergency Room: A Narrative Review Open
Sepsis remains a leading cause of global mortality, and early management in the emergency department (ED) is a key determinant of clinical outcomes. Among the earliest physiological derangements in sepsis are abnormalities in coagulation, …
View article: Proteomics-based monitoring of heatstroke recovery identifies molecular signatures of organ stress
Proteomics-based monitoring of heatstroke recovery identifies molecular signatures of organ stress Open
The findings suggest that these proteins may serve as blood biomarkers to assess heatstroke severity and monitor recovery. Their clinical application could improve early detection of organ damage and guide intervention strategies.
View article: Evaluation of Renal Function Using Cys-C After Training in a Hot Environment in Collegiate Athlete
Evaluation of Renal Function Using Cys-C After Training in a Hot Environment in Collegiate Athlete Open
In this prospective, comparative study, conducted in hot (August) and non-hot environment (November), we aimed to elucidate the usefulness using Cys-C for assessing renal function after training, focused on a hot environment. Eighteen male…
View article: Mechanism of Acute Kidney Injury in Mild to Moderate Heat-related Illness
Mechanism of Acute Kidney Injury in Mild to Moderate Heat-related Illness Open
The predominant mechanism of acute kidney injury in mild to moderate heat-related illnesses appears to be tubular damage caused by myoglobin. Measuring myoglobin levels is essential to identify and exclude patients at risk of acute kidney …
View article: Mechanism of acute kidney injury in mild to moderate heat-related illness
Mechanism of acute kidney injury in mild to moderate heat-related illness Open
Background: Heat-related illnesses cause kidney injury, and recurrent minor kidney injuries may accumulate, resulting in the development of chronic kidney disease. Despite the increased incidence, the factors responsible for kidney injury …
View article: EXAMINATION OF BENDING DEFORMATION BEHAVIORS OF CFRP WITH HELICOIDAL LAMINATE STRUCTURE BY DIC ANALYSIS
EXAMINATION OF BENDING DEFORMATION BEHAVIORS OF CFRP WITH HELICOIDAL LAMINATE STRUCTURE BY DIC ANALYSIS Open
CFRP 板の四点曲げ変形に対してデジタル画像相関法による解析を行い,らせん積層を含む3種類の積層構成についてひずみ分布を比較検討した上で,らせん積層 CFRPの変形挙動を検討した.直交積層と疑似等方積層が梁理論に従った分布を示すのに対して,らせん積層は梁理論によるものとは異なる特異な分布を示した.特に,曲げ支間において上縁で負のせん断ひずみと下縁で正のせん断ひずみを生じ,最大で 10000μ以上の非常に大きな値を示した.等価的に,曲げ支間での最大主ひずみベクトルは上縁およ…
View article: Morphological Changes in Blood Cells in a Rat Model of Heatstroke: A Pilot Study
Morphological Changes in Blood Cells in a Rat Model of Heatstroke: A Pilot Study Open
Despite the increasing threat of heatstroke with global warming, pathophysiologic injury continues to be defined. In addition, morphological changes of the peripheral blood cells in heatstroke have not been well characterized. We evaluated…
View article: Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease
Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease Open
Background: Kawasaki Disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and mainly affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysm…
View article: Supplementary Material for: Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease
Supplementary Material for: Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease Open
Introduction and Objective: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developin…
View article: EXPERIMENTAL INVESTIGATION ON DEFORMATION AND LOAD BEARING BEHAVIORS OF PARTIAL HELICOIDALLY LAMINATED CFRP UNDER FOUR-POINT FLEXURE
EXPERIMENTAL INVESTIGATION ON DEFORMATION AND LOAD BEARING BEHAVIORS OF PARTIAL HELICOIDALLY LAMINATED CFRP UNDER FOUR-POINT FLEXURE Open
既往研究の全方向全厚のらせん積層に対して，らせん積層を部分方向または部分厚で成した限定らせん積層 CFRP の四点曲げ変形・耐荷挙動を実験的に検討した．部分方向らせん積層は，最大荷重後に脆性的な挙動を示したが，その後荷重増加と降下を経て最大荷重の半分弱にまで緩やかに回復した．回復中の小さな荷重降下時にはらせん積層の階段状ひび割れが発生した．部分厚らせん積層は，2つの荷重ピークを示して荷重も半分以下に降下したが，らせん積層部分から広範囲に損傷が始まり，直交積層部分の脆性的な破…
View article: TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells
TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells Open
The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. Previous fetal thymus organ culture experiments have indicated that difference in the af…
View article: The experiment of four-point bending behaviours of helicoidally laminated CFRPs
The experiment of four-point bending behaviours of helicoidally laminated CFRPs Open
The purpose of this study is to mitigate the brittle behaviour of CFRP. CFRP is a composite material of carbon fibre and a thermosetting resin. As a feature, it has a low density than metallic materials such as steel and aluminium, and it …
View article: STUDY ON THE FLEXURAL FRACTURE BEHAVIORS OF HELICOIDALLY LAMINATED CFRP
STUDY ON THE FLEXURAL FRACTURE BEHAVIORS OF HELICOIDALLY LAMINATED CFRP Open
生体構造を模倣したらせん積層 CFRP の板曲げ挙動を実験的に検討した。一方向炭素繊維プリプレグを積層する際に層間の配向角度差を設けることでらせん積層を構成した供試体を作製している。円周支持の平板を中央点集中荷重と中央部分布荷重の条件下で，直交積層の平板と荷重一変位挙動と破壊挙動を比較した。荷重一変位挙動においては，らせん積層は中央部分布荷重下では大きな荷重降下後にも増減を繰り返しながら最大荷重に迫るレベルまで荷重増加が見られた。破壊形態においては，直交積層が局所的であるの…
View article: Thymus machinery for T-cell selection
Thymus machinery for T-cell selection Open
An immunocompetent and self-tolerant pool of naive T cells is formed in the thymus through the process of repertoire selection. T cells that are potentially capable of responding to foreign antigens are positively selected in the thymic co…
View article: Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity
Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity Open
Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor anti…
View article: INVESTIGATION ON FLEXURAL BEHAVIORS AND FAILURE MODES OF HELICOIDALLY LAMINATED CFRP
INVESTIGATION ON FLEXURAL BEHAVIORS AND FAILURE MODES OF HELICOIDALLY LAMINATED CFRP Open
CFRPは軽量にして高剛性・高強度を有する複合材料であるが，その挙動は脆性的であり線形挙動の後に突然の局所的な破壊を生じる。本研究では生体に見られるらせん積層構造を模倣することで脆性挙動の改善を検討した。一方向炭素繊維プリプレグを積層する際に層間の配向角度差を設けることでらせん積層を構成した供試体を作製した。三点および四点曲げ載荷実験を行い，直交積層と比較して，曲げ挙動と損傷・破壊挙動を詳細に観察した。曲げ挙動においては，第一ピーク荷重を経て荷重降下した後の荷重保持が大きく…
View article: Fabrication Accuracy and Material Properties of Spiral-laminated CFRP Specimens Made of UD Prepreg
Fabrication Accuracy and Material Properties of Spiral-laminated CFRP Specimens Made of UD Prepreg Open
CFRP has attracted attention as a material with lightweight, high strength and durability. Meanwhile, application of biomimetics is also receiving attention in recent years. In this study, a mantis shrimp crab is focused on. It has quite f…