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View article: An HTLV-1-Infected Humanized Mouse Model Expressing HLA-A*02:01 Demonstrates Effective CTL-Mediated Suppression of HTLV-1
An HTLV-1-Infected Humanized Mouse Model Expressing HLA-A*02:01 Demonstrates Effective CTL-Mediated Suppression of HTLV-1 Open
Human T-cell leukemia virus type 1 (HTLV-1) establishes lifelong infection and is associated with severe diseases such as adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Cytotox…
View article: Development of a novel multiplex digital PCR-based method for the detection of HTLV-1 proviral deletion
Development of a novel multiplex digital PCR-based method for the detection of HTLV-1 proviral deletion Open
The human T-cell leukemia virus type 1 (HTLV-1), a retrovirus, integrates into host DNA and causes adult T-cell leukemia/lymphoma (ATL) in some individuals. Two types of defective proviruses, Type 1 and Type 2, are often observed in ATL ce…
View article: Highly homologous simian T-cell leukemia virus type 1 genome in Japanese macaques: a large cohort study
Highly homologous simian T-cell leukemia virus type 1 genome in Japanese macaques: a large cohort study Open
Background Simian T-cell leukemia virus type 1 (STLV-1) is a retrovirus closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia (ATL). It has been shown that Japanese macaques ( Macaca f…
View article: Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus
Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus Open
Co-culture of infected and target cells is frequently used for studying HTLV-1 infection. Although this method efficiently infects HTLV-1, the cell mixture is complex, and it is extremely difficult to distinguish donor infected cells from …
View article: Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations
Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations Open
Antibody screening tests for human T-cell leukemia virus type 1 (HTLV-1) are performed based on methods such as chemiluminescent enzyme immunoassay (CLEIA), chemiluminescence immunoassay (CLIA), electrochemiluminescence immunoassay, and pa…
View article: Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial
Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial Open
View article: pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells
pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells Open
The blood–brain barrier (BBB), which is comprised of brain capillary endothelial cells, plays a pivotal role in the transport of drugs from the blood to the brain. Therefore, an analysis of proteins in the endothelial cells, such as transp…
View article: Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients Open
The cerebrovascular-specific molecular mechanism in Alzheimer’s disease (AD) was investigated by employing comprehensive and accurate quantitative proteomics. Highly purified brain capillaries were isolated from cerebral gray and white mat…
View article: Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro
Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro Open
Human T-cell leukemia virus type 1 (HTLV-1) causes serious and intractable diseases in some carriers after infection. The elimination of infected cells is considered important to prevent this onset, but there are currently no means by whic…
View article: Safety of convalescent plasma therapy for COVID-19 patients and analysis of viral kinetics: a single-center, open-label, single-arm, interventional study in Japan
Safety of convalescent plasma therapy for COVID-19 patients and analysis of viral kinetics: a single-center, open-label, single-arm, interventional study in Japan Open
Convalescent plasma therapy is an important treatment method for patients with severe coronavirus disease (COVID-19). This study was conducted to confirm the safety of this therapy. We conducted an open-label clinical trial to administer c…
View article: How we secured a <scp>COVID</scp>‐19 convalescent plasma procurement scheme in Japan
How we secured a <span>COVID</span>‐19 convalescent plasma procurement scheme in Japan Open
Background In order to tackle the COVID‐19 pandemic, a COVID‐19 convalescent plasma (CCP) procurement program was initiated in Japan in April 2020. The program was a collaboration between a government‐managed national hospital, an infectio…
View article: No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity
No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity Open
View article: HTLV-1 targets human placental trophoblasts in seropositive pregnant women
HTLV-1 targets human placental trophoblasts in seropositive pregnant women Open
Human T cell leukemia virus type 1 (HTLV-1) is mainly transmitted vertically through breast milk. The rate of mother-to-child transmission (MTCT) through formula feeding, although significantly lower than through breastfeeding, is approxim…
View article: Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan
Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan Open
View article: Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1–infected cells
Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1–infected cells Open
Patients with adult T-cell leukemia (ATL) exhibit a poor prognosis and overall survival rate when treated with standard chemotherapy, highlighting the continued requirement for the development of novel safe and effective therapies for huma…
View article: Development and evaluation of human T‐cell leukemia virus‐1 and ‐2 multiplex quantitative PCR
Development and evaluation of human T‐cell leukemia virus‐1 and ‐2 multiplex quantitative PCR Open
The diagnosis of human T ‐cell leukemia virus type 1 (HTLV‐1) infection in Japan is usually performed by serological testing, but the high rate of indeterminate results from western blotting makes it difficult to assess the infection accur…
View article: PS932 HIV INTEGRASE INHIBITOR MK-2048 INDUCES APOPTOSIS IN HTLV-1 INFECTED CELLS THROUGH THE UPR ACTIVATION
PS932 HIV INTEGRASE INHIBITOR MK-2048 INDUCES APOPTOSIS IN HTLV-1 INFECTED CELLS THROUGH THE UPR ACTIVATION Open
Background: The adult “triple negative” [Ph-/-/-; neg for t(9;22); t(1;19); t(4;11); 61% of adult B-ALL (Roberts KG et al., J Clin Oncol. 2017)] B-ALL group is characterized by an high genetic heterogeneity, lack of innovative target thera…
View article: Development of reference material with assigned value for human T‐cell leukemia virus type 1 quantitative PCR in Japan
Development of reference material with assigned value for human T‐cell leukemia virus type 1 quantitative PCR in Japan Open
Quantitative PCR (qPCR) of human T‐cell leukemia virus type 1 (HTLV‐1) provirus is used for HTLV‐1 testing and for assessment of risk of HTLV‐1‐related diseases. In this study, a reference material was developed for standardizing HTLV‐1 qP…
View article: Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor
Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor Open
Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is…
View article: Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats
Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats Open
Poststroke depression is one of the major symptoms observed in the chronic stage of brain stroke such as cerebral ischemia. Its pathophysiological mechanisms, however, are not well understood. Using the transient right middle cerebral arte…