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View article: Direct comparison of ultrasound-guided attenuation parameter and controlled attenuation parameters for steatosis using MRI-based proton density fat fraction as a reference
Direct comparison of ultrasound-guided attenuation parameter and controlled attenuation parameters for steatosis using MRI-based proton density fat fraction as a reference Open
View article: Ipragliflozin improves the hepatic outcomes of patients with diabetes with NAFLD
Ipragliflozin improves the hepatic outcomes of patients with diabetes with NAFLD Open
Sodium glucose cotransporter-2 inhibitors (SGLT2is) are now widely used to treat diabetes, but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined. We aimed to evaluate the effects of SGLT2is on the pathogenes…
View article: Diagnostic performance of attenuation imaging versus controlled attenuation parameter for hepatic steatosis with MRI-based proton density fat fraction as the reference standard: a prospective multicenter study
Diagnostic performance of attenuation imaging versus controlled attenuation parameter for hepatic steatosis with MRI-based proton density fat fraction as the reference standard: a prospective multicenter study Open
View article: Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial
Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial Open
View article: A Handheld Ultrasound Device Can Predict Constipation with Rectal Fecal Retention in a Palliative Care Setting
A Handheld Ultrasound Device Can Predict Constipation with Rectal Fecal Retention in a Palliative Care Setting Open
Although handheld ultrasound devices (HUDs) are commonplace, their ability to diagnose fecal retention (FR) remains unclear. This prospective observational study examined HUDs’ usefulness in diagnosing FR in patients with constipation in a…
View article: Skill Proficiency, Efficacy, and Safety of the Transradial Approach in Transarterial Treatments for Hepatocellular Carcinoma
Skill Proficiency, Efficacy, and Safety of the Transradial Approach in Transarterial Treatments for Hepatocellular Carcinoma Open
Introduction Abdominal angiography procedures such as transarterial chemoembolization (TACE) are essential for hepatocellular carcinoma treatment. One method commonly used is transfemoral access (TFA). However, issues associated with this …
View article: Advanced fibrosis leads to overestimation of steatosis with quantitative ultrasound in individuals without hepatic steatosis
Advanced fibrosis leads to overestimation of steatosis with quantitative ultrasound in individuals without hepatic steatosis Open
Purpose: The effect of hepatic fibrosis stage on quantitative ultrasound based on the attenuation coefficient (AC) for liver lipid quantification is controversial. The objective of this study was to determine how the degree of fibrosis ass…
View article: Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma
Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma Open
View article: Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease
Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease Open
Background: Cholesterol levels and bile acid metabolism are important drivers of metabolic dysfunction-associated steatohepatitis (MASH) progression. Using a mouse model, we investigated the mechanism by which cholesterol exacerbates MASH …
View article: Prediction of outcomes in patients with metabolic dysfunction-associated steatotic liver disease based on initial measurements and subsequent changes in magnetic resonance elastography
Prediction of outcomes in patients with metabolic dysfunction-associated steatotic liver disease based on initial measurements and subsequent changes in magnetic resonance elastography Open
View article: Clinical and histologic factors associated with discordance between steatosis grade derived from histology vs. MRI‐PDFF in NAFLD
Clinical and histologic factors associated with discordance between steatosis grade derived from histology vs. MRI‐PDFF in NAFLD Open
Summary Background Magnetic resonance imaging‐proton density fat fraction (MRI‐PDFF) is an excellent biomarker for the non‐invasive quantification of hepatic steatosis. Aim To examine clinical and histologic factors associated with discord…
View article: M‐PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis
M‐PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis Open
Background Clinical trials enroll patients with active fibrotic nonalcoholic steatohepatitis (NASH) (nonalcoholic fatty liver disease [NAFLD] activity score ≥ 4) and significant fibrosis ( F ≥ 2); however, screening failure rates are high …
View article: An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography
An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography Open
View article: Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Stage 3 Fibrosis (FALCON 1): A Randomized Phase 2b Study
Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Stage 3 Fibrosis (FALCON 1): A Randomized Phase 2b Study Open
The FALCON 1 study did not meet its primary endpoint; a ≥1-point decrease in fibrosis score without NASH worsening or NASH improvement without fibrosis worsening assessed via biopsy. Pegbelfermin was generally well tolerated during 48 week…
View article: Involvement of Periodontal Disease in the Pathogenesis and Exacerbation of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis: A Review
Involvement of Periodontal Disease in the Pathogenesis and Exacerbation of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis: A Review Open
The increasing incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), along with global lifestyle changes, requires further in-depth research to elucidate the mechanisms and develop new treatment str…
View article: Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD
Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD Open
View article: Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future
Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future Open
Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the liver without fibrosis, has been regarded as a benign …
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View article: A 3-step approach to predict advanced fibrosis in nonalcoholic fatty liver disease: impact on diagnosis, patient burden, and medical costs
A 3-step approach to predict advanced fibrosis in nonalcoholic fatty liver disease: impact on diagnosis, patient burden, and medical costs Open
View article: Comparison of long‐term prognosis between non‐obese and obese patients with non‐alcoholic fatty liver disease
Comparison of long‐term prognosis between non‐obese and obese patients with non‐alcoholic fatty liver disease Open
Background and Aim Non‐alcoholic fatty liver disease (NAFLD) can progress in non‐obese patients as in obese patients. Reports on long‐term prognosis in non‐obese NAFLD patients are controversial. Therefore, we aimed to examine the long‐ter…
View article: Head-to-head comparison between MEFIB, MAST, and FAST for detecting stage 2 fibrosis or higher among patients with NAFLD
Head-to-head comparison between MEFIB, MAST, and FAST for detecting stage 2 fibrosis or higher among patients with NAFLD Open
View article: Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study
Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study Open
Introduction Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome phenotype in the liver and thus obviously associated with metabolic abnormalities, including insulin resistance-related to hyperglycaemic and hyperlipidaemia. T…
View article: Two differentially methylated region networks in nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma
Two differentially methylated region networks in nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma Open
View article: Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study
Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study Open
INTRODUCTION: No reports on both blood and fecal bile acids (BAs) in patients with nonalcoholic fatty liver disease (NAFLD) exist. We simultaneously assessed the serum and fecal BA patterns in healthy participants and those with NAFLD. MET…
View article: A meta-analysis of the diagnostic accuracy of type Ⅳ collagen 7S for the staging of liver fibrosis in NAFLD
A meta-analysis of the diagnostic accuracy of type Ⅳ collagen 7S for the staging of liver fibrosis in NAFLD Open
We aimed to evaluate the diagnostic accuracy of the measurement of type Ⅳ collagen 7S (T4C7S) concentration for the staging of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). A systematic literature search was per…
View article: A 3-step approach to predict advanced fibrosis in nonalcoholic fatty liver disease: Impact on diagnosis, patient burden, and medical costs
A 3-step approach to predict advanced fibrosis in nonalcoholic fatty liver disease: Impact on diagnosis, patient burden, and medical costs Open
A 2-step approach, Fibrosis-4 index (FIB-4) followed by vibration-controlled transient elastography (VCTE), has been proposed to predict advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to develop a nov…
View article: Combination of tofogliflozin and pioglitazone for NAFLD: Extension to the ToPiND randomized controlled trial
Combination of tofogliflozin and pioglitazone for NAFLD: Extension to the ToPiND randomized controlled trial Open
The incidence of nonalcoholic fatty liver disease (NAFLD) has recently increased and is related to obesity and the associated surge in type 2 diabetes mellitus (T2DM) and metabolic syndromes. This trial follows up on our previous work and …
View article: Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial
Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial Open
Opioid-induced constipation (OIC) may occur in patients receiving opioid treatment, decreasing their quality of life (QOL). We compared the effectiveness of magnesium oxide (MgO) with that of naldemedine (NAL) in preventing OIC. This proof…
View article: Two Differentially Methylated Region (DMR) Networks in Nonalcoholic Fatty Liver Disease, Viral Hepatitis, and Hepatocellular Carcinoma
Two Differentially Methylated Region (DMR) Networks in Nonalcoholic Fatty Liver Disease, Viral Hepatitis, and Hepatocellular Carcinoma Open
Background We previously reported that two differentially methylated region (DMR) networks identified by DMR, and co-methylation analyses are strongly correlated with the fibrosis stages of nonalcoholic fatty liver disease (NAFLD). In the …
View article: Magnetic resonance imaging for the assessment of pathological hepatic findings in nonalcoholic fatty liver disease
Magnetic resonance imaging for the assessment of pathological hepatic findings in nonalcoholic fatty liver disease Open
現在肥満や糖尿病が急増していることから,非アルコール性脂肪性肝疾患(nonalcoholic fatty liver disease:NAFLD)の有病率は上昇することが予想され,世界中で慢性肝疾患の主因となっている.肝線維化は,NAFLD患者の長期転帰の悪化と関連がある.さらに,死亡率の上昇と肝疾患の合併症は,主に非アルコール性脂肪性肝炎(nonalcoholic steatohepatitis:NASH)患者に見られるが,非アルコール性脂肪肝(nonalcoholic …