Explanipedia

Artifactual hypoglycemia caused by Raynaud’s phenomenon: A case report with literature review Open

Hidenori Nishioka, Yoshifumi Itoda, Chikako Ichikawa, Masahiro Takubo, Akiko Nagasawa , et al. · 2025

Finger-stick glucose monitoring is commonly used in the clinical management of diabetes as a tool to obtain a reliable estimate of venous glucose levels. However, it should be noted that discrepancies can arise in certain situations betwee…

Elucidation of pressure wave attenuation due to cross-sectional area change in bubbly flow Open

Kentaro Watanabe, Tetsuya Kanagawa, Takahiro Ayukai · 2025

Genome profiling with targeted adaptive sampling long-read sequencing for pediatric leukemia Open

Shota Kato, Aiko Sato‐Otsubo, Wataru Nakamura, Masahiro Sugawa, Ai Okada , et al. · 2024

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Surveillance of SARS-CoV-2 Infection in Rodent Populations in Tokyo, Japan Open

Yudai Kuroda, Akitoyo Hotta, Masakatsu Taira, Nobuo Koizumi, Kango Tatemoto , et al. · 2024

The persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among wildlife populations poses a potential risk for the emergence of novel variants. Therefore, monitoring SARS-CoV-2 infections in animals is crucial. As ur…

Late-onset Neutropenia after Rituximab Treatment for MPO-ANCA-associated Vasculitis Open

Kentaro Watanabe, Noriaki Shimada, Motoko Kanzaki, Kosuke Fukuoka, Kenichiro Asano · 2024

An underestimated side effect of rituximab is late-onset neutropenia (R-LON), which often resolves spontaneously and rarely results in a severe infection. We herein report a case of febrile neutropenia due to R-LON in a 91-year-old woman w…

A case diagnosed with IgA nephropathy during a complete remission of minimal change nephrotic syndrome treated with rituximab Open

Mana Nishikawa, Noriaki Shimada, Motoyasu Kurahashi, Kentaro Watanabe, Motoko Kanzaki , et al. · 2024

Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression Open

Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato, Hiroo Ueno , et al. · 2024

Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mortality rate. Modern transcriptomics techniques can identify differentially expressed genes (DEGs) that may serve as …

Elucidation of Attenuation Factors Due to Cross-Sectional Area Change Of Pressure Wave in Bubbly Flow Open

Kentaro Watanabe, Tetsuya Kanagawa, Takahiro Ayukai · 2024

Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression Open

Junko Takita, Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato , et al. · 2023

Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mortality rate. Modern transcriptomics techniques can identify differentially expressed genes (DEGs) that may serve as …

Identification of the ultrahigh-risk subgroup in neuroblastoma cases through DNA methylation analysis and its treatment exploiting cancer metabolism Open

Kentaro Watanabe, Shunsuke Kimura, Masafumi Seki, Tomoya Isobe, Yasuo Kubota , et al. · 2022

Neuroblastomas require novel therapies that are based on the exploitation of their biological mechanism. To address this need, we analyzed the DNA methylation and expression datasets of neuroblastomas, extracted a candidate gene characteri…

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia Open

Tomoya Isobe, Masatoshi Takagi, Aiko Sato‐Otsubo, Akira Nishimura, Genta Nagae , et al. · 2022

Description of longitudinal tumor evolution in a case of multiply relapsed clear cell sarcoma of the kidney Open

Tomoki Yaguchi, Shunsuke Kimura, Masahiro Sekiguchi, Yasuo Kubota, Masafumi Seki , et al. · 2021

Background Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Case A 2‐year‐old boy was diagnosed with CCSK, which relapsed four times until he yielded to the disease at the age of 7 years. To characte…

Experiments on boiling heat transfer and pressure drop of refrigerant mixtures R245fa/R1234ze(E) inside horizontal microfin tubes. Open

Kentaro Watanabe, Y Liu, Daisuke Jige · 2021

This study experimentally investigated the boiling heat transfer and pressure drop characteristics of R245fa/R1234ze(E) zeotropic refrigerant mixtures inside horizontal microfin tubes. The test tubes were copper tubes with an outer diamete…

Experiments on boiling heat transfer and pressure drop of lowpressure, low-GWP refrigerants inside a horizontal microfin tube. Open

Kentaro Watanabe, Y Liu, Daisuke Jige, M. Inoue · 2021

Cardio-ankle Vascular Index Is More Closely Associated Than Brachial-ankle Pulse Wave Velocity With Variables Predicting Future Cardiovascular Disease in Patients With Diabetes Open

Taro Saigusa, Kentaro Watanabe, Yurika Hada, Kota Ishii, Wataru Kameda , et al. · 2021

Background: This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating future cardiovascular disease (CVD) in subjects with…

A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder Open

Makoto Osada, Keiko Maruyama, Koichi Kokame, Ryunosuke Denda, Kohei Yamazaki , et al. · 2021

We report a 19-year-old Vietnamese woman who experienced several life-threatening bleeding events, including ovarian hemorrhage. Blood analysis revealed a decreased fibrinogen level with markedly elevated fibrinogen/fibrin degradation prod…

Hand function and cost effectiveness after collagenase injection versus aponeurectomy for Dupuytren’s contracture: results of the CeCORD-J study Open

Michiro Yamamoto, Hideo Yasunaga, Ryosuke Kakinoki, Naoto Tsubokawa, Akimasa Morita , et al. · 2021

BackgroundThis study compared hand function and the cost effectiveness of treatment between collagenase Clostridium histolyticum (CCH) injection and limited fasciectomy for patients with Dupuytren’s contracture (DC).Materials and MethodsTh…

Alveolar Epithelial Denudation Is a Major Factor in the Pathogenesis of Pleuroparenchymal Fibroelastosis Open

Yoshiaki Zaizen, Yuri Tachibana, Yukio Kashima, Andrey Bychkov, Kazuhiro Tabata , et al. · 2021

The pathogenesis of pleuroparenchymal fibroelastosis (PPFE), a rare interstitial lung disease, remains unclear. Based on previous reports and our experience, we hypothesized that alveolar epithelial denudation (AED) was involved in the pat…

Association of high-risk neuroblastoma classification based on expression profiles with differentiation and metabolism Open

Shunsuke Kimura, Masahiro Sekiguchi, Kentaro Watanabe, Mitsuteru Hiwatarai, Masafumi Seki , et al. · 2021

Neuroblastoma, the most common extracranial solid malignancy among children, originates from undifferentiated neural crest cells (NCC). Despite recent intensified treatment, high-risk patients still have a high mortality rate. To explore a…

Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets Open

Yasuo Kubota, Masafumi Seki, Tomoko Kawai, Tomoya Isobe, Misa Yoshida , et al. · 2020

To elucidate the molecular pathogenesis of pediatric germ cell tumors (GCTs), we performed DNA methylation array analysis, whole transcriptome sequencing, targeted capture sequencing, and single-nucleotide polymorphism array analysis using…

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets Open

Masahiro Sekiguchi, Masafumi Seki, Tomoko Kawai, Kenichi Yoshida, Misa Yoshida , et al. · 2020

A Case of Pulmonary Sarcoidosis with Pneumothorax and Fungus Ball Combinend with Multiple Cavitary Lesion Open

Satoshi Takeda, Nobuhiko Nagata, Yusuke Ueda, Yūji Yoshida, Taishi Harada , et al. · 2019

28歳男性．X－4年7月ぶどう膜炎を指摘される．胸部X線で両側肺門リンパ節腫張も認めており当科に紹介となった．精査を予定していたが，本人の自己判断で検査入院も中止となった．X年4月下旬より咳・喀痰・微熱が出現，症状改善ないためX年5月上旬当科受診．胸部CTで両肺に空洞を伴う多発肺結節影を認め，X年5月中旬経気管支内視鏡肺生検を施行．非乾酪性類上皮細胞肉芽腫を認め，サルコイドーシスに特徴的な検査所見として両側肺門リンパ節腫脹（BHL），可溶性IL-2R上昇（2330 U/mL…

Association of Immune Thrombocytopenia and Interstitial Pneumonia Open

Hisako Kushima, Yoshiaki Kinoshita, Kentaro Watanabe, Yasushi Takamatsu, Hiroshi Ishii · 2019

Objective Chest physicians often encounter patients with interstitial pneumonia with autoimmune features. However, there have so far been few reports of patients presenting with concurrent immune thrombocytopenia (ITP) and interstitial pne…

A rare case of unruptured extracardiac multiple sinus of Valsalva aneurysms originating from the orifices with partial aortic wall defects Open

Nobuhisa Ohno, Kentaro Watanabe, Toshi Maeda, Otohime Kato, Go Ueno , et al. · 2019

Predictors of parental distress during acute phase of pediatric hematopoietic stem cell transplantation in Japan: A multicenter prospective study Open

Shohei Nakajima, Ami Setoyama, Iori Sato, Tomoko Fukuchi, Harumi Tanaka , et al. · 2019

The medical staff should understand that parents of children undergoing HSCT experience considerable psychological distress throughout the treatment process, and therefore, they should adopt unique approaches to reduce such distress.

Pulmonary Sarcoidosis Presenting with Thin-walled Small Cysts Open

Hisako Kushima, Hiroshi Ishii, Jun‐ichi Kadota, Kentaro Watanabe · 2017

Poor pharmacological adherence to inhaled medicines compared with oral medicines in Japanese patients with asthma and chronic obstructive pulmonary disease Open

Yohei Imamura, Tomotaka Kawayama, Takashi Kinoshita, Yuki Sakazaki, Makoto Yoshida , et al. · 2016

Surgical repair of tricuspid regurgitation due to annular detachment caused by chest trauma Open

Shingo Hirao, Kenji Minakata, Hisashi Sakaguchi, Kentaro Watanabe, Kazuhiro Yamazaki , et al. · 2016

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease Open

Keiji Kono, Hideki Fujii, Kentaro Nakai, Shunsuke Goto, Shuhei Watanabe , et al. · 2016

Background/Aims: Hypertension (HT) is a common complication in patients with chronic kidney disease (CKD). However, the relationship between circadian rhythm disorder of blood pressure (BP) and intra-renal damage remains uncl…

Multicenter cooperative observational study of idiopathic pulmonary fibrosis with non-small cell lung cancer Open

Noriyuki Ebi, Shoji Tokunaga, Kazunobu Itoh, Isamu Okamoto, Nobutaka Edakuni , et al. · 2016

Multicenter cooperative observational study of idiopathic pulmonary fibrosis with non-small cell lung cancer

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