Kerry Kingham
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View article: Breast Cancer MRI Screening of Patients After Multiplex Gene Panel Testing
Breast Cancer MRI Screening of Patients After Multiplex Gene Panel Testing Open
Importance Enhanced breast cancer screening with magnetic resonance imaging (MRI) is recommended to women with elevated risk of breast cancer, yet uptake of screening remains unclear after genetic testing. Objective To evaluate uptake of M…
View article: Germline <i>CDH1</i> Variants and Lifetime Cancer Risk
Germline <i>CDH1</i> Variants and Lifetime Cancer Risk Open
Importance Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breas…
View article: Abstract P6-02-07: Uptake of Breast Cancer MRI Screening in Patients After Multiplex Gene Panel Testing
Abstract P6-02-07: Uptake of Breast Cancer MRI Screening in Patients After Multiplex Gene Panel Testing Open
Purpose: Multiplex gene panel testing (MGPT) is used to identify individuals with an inherited susceptibility to cancer. However, little is known about the uptake of screening and surveillance among patients after MGPT and genetic counseli…
View article: How should we address the inevitable harms from non‐negligent variant reclassification in predictive genetic testing?
How should we address the inevitable harms from non‐negligent variant reclassification in predictive genetic testing? Open
The process of interpreting genetic variants, in which experts use all available evidence to determine whether an identified variant is associated with a current or future disease, is both scientific and nevertheless subjective. In this pa…
View article: Prevalence of Lynch syndrome in women with mismatch repair‐deficient ovarian cancer
Prevalence of Lynch syndrome in women with mismatch repair‐deficient ovarian cancer Open
Background There are limited data on the prevalence of Lynch syndrome (LS) in women with primary ovarian cancer with mismatch repair deficiency (MMR‐D) by immunohistochemistry (IHC). Materials and Methods Three hundred and eight cases of p…
View article: Psychosocial outcomes following germline multigene panel testing in an ethnically and economically diverse cohort of patients
Psychosocial outcomes following germline multigene panel testing in an ethnically and economically diverse cohort of patients Open
Background Little is known about the psychological outcomes of germline multigene panel testing, particularly among diverse patients and those with moderate‐risk pathogenic variants (PVs). Methods Study participants (N = 1264) were counsel…
View article: Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk
Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk Open
Purpose Multiplex gene panel testing (MGPT) allows for the simultaneous analysis of germline cancer susceptibility genes. This study describes the diagnostic yield and patient experiences of MGPT in diverse populations. Patients and Method…
Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative Open
In cascade testing, genetic testing for an identified familial pathogenic variant extends to disease-free relatives to allow genetically targeted disease prevention. We evaluated the results of an online initiative in which carriers of 1 o…
View article: Patient communication of cancer genetic test results in a diverse population
Patient communication of cancer genetic test results in a diverse population Open
Research on the communication of genetic test results has focused predominately on non-Hispanic White (NHW) mutation-positive families with high-risk hereditary cancer conditions. Little is known about this process for racially and ethnica…