Kerry Kizer
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View article: Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis
Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis Open
Background: The complement system has been suspected to play a role in multiple sclerosis (MS) due to presence of complement activation products in MS lesions. Objective: We sought to understand whether variation in the complement componen…
View article: MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge Open
The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short-read, de novo assembly algori…
View article: Antigen specificity of clonally-enriched CD8+ T cells in multiple sclerosis
Antigen specificity of clonally-enriched CD8+ T cells in multiple sclerosis Open
CD8+ T cells are the dominant lymphocyte population in multiple sclerosis (MS) lesions where they are highly clonally expanded. The clonal identity, function, and antigen specificity of CD8+ T cells in MS are not well understood. Here we r…
View article: MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge
MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge Open
The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short read de novo assembly algorit…
View article: An autoantibody signature predictive for multiple sclerosis
An autoantibody signature predictive for multiple sclerosis Open
View article: A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection Open
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic 1–4 . Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique oppor…