Kerstin Iverfeldt
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View article: Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair
Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair Open
Fe65 is a brain enriched adaptor protein involved in various cellular processes, including actin cytoskeleton regulation, DNA repair and transcription. A well-studied interacting partner of Fe65 is the transmembrane amyloid-β precursor pro…
View article: Author Index
Author Index Open
View article: Fe65 electrophoretic mobility shift due to phosphorylation is not detected in the nuclear fraction.
Fe65 electrophoretic mobility shift due to phosphorylation is not detected in the nuclear fraction. Open
A. Western blot analysis of Fe65 in cytoplasmic (C1) and nuclear (N1) fractions after incubation in the absence or presence of alkaline phosphatase. Two different exposure times are shown for optimal visualization of Fe65 in the different …
View article: Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis Open
Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-β precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in hu…
View article: Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution
Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution Open
FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought. One important aspect to consider when designing FR…