Kerstin Stein
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View article: Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome
Reduced CD40 expression in B cell subsets of individuals with radiologically isolated syndrome Open
Introduction B cells play a central role in multiple sclerosis (MS) pathogenesis, yet their activation profiles during the earliest disease stages remain incompletely characterized. We aimed to investigate the expression of the activation …
View article: Pruritus in primary biliary cholangitis: insights from the German PBC registry across secondary and tertiary care
Pruritus in primary biliary cholangitis: insights from the German PBC registry across secondary and tertiary care Open
Pruritus in patients with PBC is common and under-treated in the real-world scenario. Assessment and management vary by healthcare level, highlighting the need for standardized care and greater awareness of treatment options across all set…
View article: Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis
Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis Open
Intrathecal complement activation is consistently associated with MRI metrics and liquid biomarkers indicative for MS disease activity and progression. Our results demonstrate that aberrant complement activation is strongly associated with…
View article: Complement Activation Is Associated With Disease Severity in Multiple Sclerosis
Complement Activation Is Associated With Disease Severity in Multiple Sclerosis Open
CNS-compartmentalized activation of the classical and alternative pathways of complement is increased in CIS/MS and associated with the presence of an intrathecal IgM production. Increased complement activation within the CSF correlates wi…
View article: A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B
A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B Open
As HBeAg-negative patients with chronic hepatitis B on nucleos(t)ide analogues (NUCs) rarely achieve functional cure, treatment is almost always lifelong. The STOP-NUC trial was conducted to investigate whether discontinuing long-term NUC …
View article: The Fatty Liver Assessment in Germany (FLAG) cohort study identifies large heterogeneity in NAFLD care
The Fatty Liver Assessment in Germany (FLAG) cohort study identifies large heterogeneity in NAFLD care Open
FLAG is a real-world cohort study that examined the liver disease burden in secondary and tertiary care. Herein, 10% of patients referred to secondary care for NAFLD exhibited advanced liver disease, whilst 64% had no significant liver sca…
View article: Real-Life Experiences with Telaprevir in the Treatment of Chronic Genotype 1 Hepatitis C — The TEPS Study
Real-Life Experiences with Telaprevir in the Treatment of Chronic Genotype 1 Hepatitis C — The TEPS Study Open
As one of the first Direct Acting Antivirals (DAA), the protease inhibitor Telaprevir (TVR) was available in the European Union from 9/2011 until 9/2016 as a new treatment option for chronic Hepatitis C.Aim. To assess the implementation of…
View article: Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism
Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism Open
The aim of the study was to evaluate the serological rate of Helicobacter pylori (H. pylori) infection in patients with chronic hepatitis C virus (HCV) infection and determine any correlations with liver damage and IL28B single-nucleotide …
View article: Predictors of functional benefit of hepatitis C therapy in a ‘real-life’ cohort
Predictors of functional benefit of hepatitis C therapy in a ‘real-life’ cohort Open
Our data may contribute to the discussion of potential risks and benefits of antiviral therapy with individual patients infected with HCV and with advanced liver disease.
View article: Interferon-free treatment of chronic hepatitis C virus infection in patients with inherited bleeding disorders
Interferon-free treatment of chronic hepatitis C virus infection in patients with inherited bleeding disorders Open
Summary Chronic hepatitis C virus (HCV) infection causes significant mortality in patients with inherited bleeding disorders, however, data of interferon-free antiviral regimes are scarce in this population. Patients, methods: Reallife dat…