Kesavan Muralidharan
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View article: 233. DYNAMIC POSTURAL CONTROL IN REMITTED BIPOLAR I DISORDER: A CDP STUDY
233. DYNAMIC POSTURAL CONTROL IN REMITTED BIPOLAR I DISORDER: A CDP STUDY Open
Background Postural sway is documented in Bipolar I disorder (BD). Emerging evidence suggests overlap between brain areas implicated in the pathophysiology of BD and vestibular activity in the brainstem. Computerized Dynamic Posturography …
View article: Socio-cognitive processes in mild-moderate depression
Socio-cognitive processes in mild-moderate depression Open
Background Social cognition (SC), the ability to interpret and respond to social situations appropriately, is essential for effective interpersonal functioning. Challenges in these areas are a core feature of depression. Evidence shows mix…
View article: Efficacy and Safety of Haloperidol in the Prevention and Management of Delirium in Medical Inpatients: An Umbrella Review of Systematic Reviews
Efficacy and Safety of Haloperidol in the Prevention and Management of Delirium in Medical Inpatients: An Umbrella Review of Systematic Reviews Open
Objective: Delirium occurs in up to 31% of general hospital patients in the medical, surgical, or critical care wards. Agitation is common during hyperactive delirium, which poses a risk to themselves, other patients, or staff. Evidence fo…
View article: Immunological memory in infected & exposure näive individuals one year post SARS-CoV-2 vaccination
Immunological memory in infected & exposure näive individuals one year post SARS-CoV-2 vaccination Open
Background & objectives COVID-19 has affected millions and wreaked havoc on global healthcare systems as well as a devastating impact on the economies of various nations. Vaccines are highly pivotal in promoting an appropriate immune respo…
View article: Develop an Artificial Intelligence Model Solution to Refine CAPTCHA
Develop an Artificial Intelligence Model Solution to Refine CAPTCHA Open
Completely Automated Public Turing tests to narrate Computers and Humans Apart (CAPTCHAs) are established for protection purposes, but their growing complicatedness frequently hampers consumer occurrence. This project presents a Machine Le…
View article: Software Performance Monitoring Using Machine Learning Algorithms
Software Performance Monitoring Using Machine Learning Algorithms Open
Software performance monitoring is crucial for maintaining system efficiency and reliability. Traditional methods rely on static rule-based approaches, which may not effectively predict performance degradation. This study proposes a machin…
View article: A Randomized Open-Label Parallel-Group Study Evaluating the Efficacy and Safety of Candesartan Cilexetil and Amlodipine in Mild to Moderate Essential Hypertensives in a Tertiary Care Hospital in Chennai
A Randomized Open-Label Parallel-Group Study Evaluating the Efficacy and Safety of Candesartan Cilexetil and Amlodipine in Mild to Moderate Essential Hypertensives in a Tertiary Care Hospital in Chennai Open
Objective: This research compared the effectiveness of combining amlodipine and candesartan in treating mild to moderate hypertensive patients. It suggests using drugs from different groups to achieve target blood pressure levels, as per c…
View article: Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations
Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations Open
Background Schizophrenia is one of the most burdensome psychiatric disorders. Novel neuromodulatory techniques including cathodal transcranial direct current stimulation (c-tDCS) and continuous theta burst stimulation (cTBS) using repetiti…
View article: ESCITALOPRAM VS BUPROPION AS ADJUNCTIVE TREATMENT FOR ACUTE BIPOLAR I DEPRESSION: A MULTI-CENTER OPEN LABEL TRIAL
ESCITALOPRAM VS BUPROPION AS ADJUNCTIVE TREATMENT FOR ACUTE BIPOLAR I DEPRESSION: A MULTI-CENTER OPEN LABEL TRIAL Open
Background Modern anti-depressants such as escitalopram and bupropion are widely used in clinical practice settings for the treatment of acute bipolar I depression. However, the data on the efficacy of these anti-depressants is limited and…
View article: Efficacy and Tolerability of Cariprazine as Monotherapy for Acute Bipolar Depression: A Systematic Review and Meta-analysis
Efficacy and Tolerability of Cariprazine as Monotherapy for Acute Bipolar Depression: A Systematic Review and Meta-analysis Open
Background: Bipolar depression (BDep) presents a significant clinical challenge with limited treatment options. The second-generation antipsychotics are increasingly utilized as primary or adjunct treatments. The use of cariprazine as mono…
View article: Impact of EEG Reference Schemes on Event-Related Potential Outcomes: A Corollary Discharge Study Using a Talk/Listen Paradigm
Impact of EEG Reference Schemes on Event-Related Potential Outcomes: A Corollary Discharge Study Using a Talk/Listen Paradigm Open
The selection of an appropriate virtual reference schema is pivotal in determining the outcomes of Event-Related Potential (ERP) studies, particularly within the widely utilized Talk/Listen ERP paradigm, which is employed to non-invasively…
View article: Impact of EEG Reference Schemes on Event-Related Potential Outcomes: A Corollary Discharge Study Using a Talk/Listen Paradigm.
Impact of EEG Reference Schemes on Event-Related Potential Outcomes: A Corollary Discharge Study Using a Talk/Listen Paradigm. Open
The selection of an appropriate virtual reference schema is pivotal in determining the outcomes of Event-Related Potential (ERP) studies, particularly within the widely utilized Talk/Listen ERP paradigm, which is employed to non-invasively…
View article: Clinical and radiological spectrum of acquired inflammatory demyelinating diseases of the central nervous system in a tertiary care center
Clinical and radiological spectrum of acquired inflammatory demyelinating diseases of the central nervous system in a tertiary care center Open
Objectives: Demyelinating diseases of central nervous system (CNS) are a broad spectrum of conditions with autoimmune process against myelin. In a resource limited country like India, it is imperative to perform proper clinical evaluation,…
View article: Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations
Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations Open
Background Schizophrenia is one of the most burdensome psychiatric disorders. Novel neuromodulatory techniques including cathodal transcranial direct current stimulation (c-tDCS) and continuous theta burst stimulation (cTBS) using repetiti…
View article: Ralstonia mannitolilytica septicaemia, an added burden in cancer care: Recognizing the unrecognized
Ralstonia mannitolilytica septicaemia, an added burden in cancer care: Recognizing the unrecognized Open
Background: Ralstonia mannitolilytica is an often underrecognized pathogen, that can cause infections in immunocompromised hosts. The propensity to form biofilms makes it particularly likely to cause catheter related infections, which is u…
View article: Long-term Add-on Yoga Therapy Modulates Oxidative Stress Pathway and Offers Clinical Benefits in Major Depressive Disorder: A Randomized Controlled Trial
Long-term Add-on Yoga Therapy Modulates Oxidative Stress Pathway and Offers Clinical Benefits in Major Depressive Disorder: A Randomized Controlled Trial Open
Background: Yoga therapy (YT) as an adjunct treatment has reportedly been demonstrated to offer clinical benefits in major depressive disorder (MDD). Although a few biological pathways are suggested to mediate the effects of yoga, the prec…
View article: Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine
Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine Open
Bipolar disorder’s core feature is the pathological disturbances in mood, often accompanied by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a range of inherited and environmental factors are involved…
View article: Neurocognitive Deficits in Recently Diagnosed Young Remitted Bipolar I Disorder and At-Risk Subjects: Potential Endophenotypes?
Neurocognitive Deficits in Recently Diagnosed Young Remitted Bipolar I Disorder and At-Risk Subjects: Potential Endophenotypes? Open
Background: Neurocognitive deficits have been reported consistently in euthymic bipolar disorder (BD) across studies. Endophenotype potential of such deficits have been reported in a few studies. However, data from the Indian subcontinent …
View article: Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder
Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder Open
Both Factor B and Factor H are crucial in the induction and regulation of the alternative pathway of complement activation. The alternative pathway also plays a critical role in inflammation. These findings suggest an important role of the…
View article: Effectiveness of Short-Term Lifestyle Modification on Reducing Body- Weight-Related Parameters in Persons with Severe Mental Illness: A Randomized Controlled Trial
Effectiveness of Short-Term Lifestyle Modification on Reducing Body- Weight-Related Parameters in Persons with Severe Mental Illness: A Randomized Controlled Trial Open
Background: Persons with severe mental illness (SMI) reportedly have a high mortality rate due to metabolic syndrome (MS). However, lifestyle modification (LM) offers effective management of some components of MS. This study aimed to evalu…
View article: Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes Open
Whole Exome Sequencing (WES) studies provide important insights into the genetic architecture of serious mental illness (SMI). Genes that are central to the shared biology of SMIs may be identified by WES in families with multiple affected…