Keun Ah Ryu
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View article: High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface Open
View article: μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping
μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping Open
The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. E…
View article: CCDC 2093827: Experimental Crystal Structure Determination
CCDC 2093827: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Targeted proximity-labelling of protein tyrosines <i>via</i> flavin-dependent photoredox catalysis with mechanistic evidence for a radical–radical recombination pathway
Targeted proximity-labelling of protein tyrosines <i>via</i> flavin-dependent photoredox catalysis with mechanistic evidence for a radical–radical recombination pathway Open
Labelling of protein tyrosines with phenol-containing tags is shown using riboflavin based-photocatalysts with a smaller labelling radius than peroxidase-based methods. Mechanistic insight also suggests a radical recombination mechanism.
View article: Near-Infrared Photoredox Catalyzed Tryptophan Functionalization for Peptide Stapling and Protein Labeling in Complex Tissue Environments
Near-Infrared Photoredox Catalyzed Tryptophan Functionalization for Peptide Stapling and Protein Labeling in Complex Tissue Environments Open
The chemical transformation of aromatic amino acids has emerged as an attractive alternative to non-selective lysine or cysteine labeling for the modification of biomolecules. However, this strategy has largely been limited by the scope of…
View article: Targeted activation in localized protein environments via deep red photoredox catalysis
Targeted activation in localized protein environments via deep red photoredox catalysis Open
View article: High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions
High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions Open
Identifying protein environments at the virus-host cell interface can improve our understanding of viral entry and pathogenesis. SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic, uses the cell surface ACE2 protein as a major rece…
View article: Small molecule photocatalysis enables drug target identification via energy transfer
Small molecule photocatalysis enables drug target identification via energy transfer Open
Over half of new therapeutic approaches fail in clinical trials due to a lack of target validation. As such, the development of new methods to improve and accelerate the identification of cellular targets, broadly known as target ID, remai…
View article: Mechanistic Evidence for a Radical-Radical Recombination Pathway of Flavin-based Photocatalytic Tyrosine Labeling
Mechanistic Evidence for a Radical-Radical Recombination Pathway of Flavin-based Photocatalytic Tyrosine Labeling Open
We recently introduced flavin-based photocatalysts such as riboflavin tetraacetate (RFT) as a robust platform for light- mediated protein labeling via phenoxyl radical-mediated tyrosine-biotin phenol coupling on live cells. To gain insight…
View article: Electroaffinity Labeling: A New Platform for Chemoproteomic-based Target Identification
Electroaffinity Labeling: A New Platform for Chemoproteomic-based Target Identification Open
Target identification is a critical pillar within the drug discovery process that involves deconvoluting the protein target of a pharmacologically active small molecule ligand. While photoaffinity labeling strategies have become the benchm…
View article: Targeted Activation in Localized Protein Environments via Deep Red Photoredox Catalysis
Targeted Activation in Localized Protein Environments via Deep Red Photoredox Catalysis Open
State-of-the art photoactivation strategies in chemical biology provide spatiotemporal control and visualization of biological processes. However, using high energy light (λ < 500 nm) for substrate or photocatalyst sensitization can lead t…
View article: Targeted Activation in Localized Protein Environments via Deep Red Photoredox Catalysis
Targeted Activation in Localized Protein Environments via Deep Red Photoredox Catalysis Open
State-of-the art photoactivation strategies in chemical biology provide spatiotemporal control and visualization of biological processes. However, using high energy light (λ < 500 nm) for substrate or photocatalyst sensitization can lead t…
View article: Small molecule photocatalysis enables drug target identification via energy transfer
Small molecule photocatalysis enables drug target identification via energy transfer Open
The identification of cellular targets that can be exploited for therapeutic benefit, broadly known as target ID, remains a fundamental goal in drug discovery. In recent years, the application of new chemical and biological technologies th…
View article: Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing use of visible‐light photochemistry in both chemistry and biology, no general low‐heat photoreactor for use across these different disciplines exists. Herein, we describe the design and use of a standardized photoreacto…
View article: Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a s…
View article: Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a s…
View article: Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist Open
View article: Polyelectrolyte‐Enrobed Cancer Cells in View of Personalized Immune‐Therapy
Polyelectrolyte‐Enrobed Cancer Cells in View of Personalized Immune‐Therapy Open
Targeting the immune system with a personalized vaccine containing cues derived from the patient's malignancy might be a promising approach in the fight against cancer. It includes neo‐antigens as well as nonmutated tumor antigens, prefere…
View article: Spatial and Temporal Control of Immune Cell Activation
Spatial and Temporal Control of Immune Cell Activation Open
The innate control of adaptive immunity has been the target of various therapeutics. By the chemical modification of the chemical patterns recognized by the Toll-like receptors (TLRs) on innate immune cells, we can further control the syst…
View article: Immune Response Modulation of Conjugated Agonists with Changing Linker Length
Immune Response Modulation of Conjugated Agonists with Changing Linker Length Open
We report immune response modulation with linked Toll-like receptor (TLR) agonists. Conjugating two agonists of synergistic TLRs induce an increase in immune activity compared to equal molarity of soluble agonists. Additionally, varying th…
View article: In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity Open