Keven Ang
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View article: Association between cognitive function in visuospatial‐construction and immediate memory domains with quality of life in patients with type 2 diabetes
Association between cognitive function in visuospatial‐construction and immediate memory domains with quality of life in patients with type 2 diabetes Open
Background Patients with type 2 diabetes (T2D) have increased susceptibility to cognitive impairment and experience poorer quality of life (QOL). It is unknown which domains of cognitive function are associated with QOL. We aimed to study …
View article: Association between cognitive function in visuospatial‐construction and immediate memory domains with quality of life in patients with type 2 diabetes
Association between cognitive function in visuospatial‐construction and immediate memory domains with quality of life in patients with type 2 diabetes Open
Background Patients with type 2 diabetes (T2D) have increased susceptibility to cognitive impairment and experience poorer quality of life (QOL). It is unknown which domains of cognitive function are associated with QOL. We aimed to study …
View article: Phase angle was associated with improved cognitive function over time with mediation from pulse wave velocity in type 2 diabetes mellitus
Phase angle was associated with improved cognitive function over time with mediation from pulse wave velocity in type 2 diabetes mellitus Open
Background Phase angle (PhA) is the angle of vector which comprises the body's resistance and reactance. It reflects nutritional status with higher levels signifying healthier cell membrane and higher muscle mass. Although higher PhA was a…
View article: <b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b>
<b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b> Open
We aim to investigate the association between plasma angiogenin and the risk of progression to end-stage kidney disease (ESKD) in Type 2 Diabetes (T2D) patients and attempted to infer the causal relationship between plasma angiogenin and c…
View article: <b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b>
<b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b> Open
We aim to investigate the association between plasma angiogenin and the risk of progression to end-stage kidney disease (ESKD) in Type 2 Diabetes (T2D) patients and attempted to infer the causal relationship between plasma angiogenin and c…
View article: Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation
Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation Open
A high level potassium intake estimated from urine potassium excretion was independently associated with a low risk of MACE in patients with type 2 diabetes. Increasing potassium intake may be a potential effective strategy for cardiovascu…
View article: Acute kidney injury predicts the risk of adverse cardio renal events and all cause death in southeast Asian people with type 2 diabetes
Acute kidney injury predicts the risk of adverse cardio renal events and all cause death in southeast Asian people with type 2 diabetes Open
Patients with diabetes are susceptible to acute kidney injury (AKI) as compared to counterparts without diabetes. However, data on the long-term clinical outcome of AKI specifically in people with diabetes are still scarce. We sought to st…
View article: The association between osteoprotegerin and arterial stiffness in a 10-year longitudinal study of patients with type 2 diabetes
The association between osteoprotegerin and arterial stiffness in a 10-year longitudinal study of patients with type 2 diabetes Open
Introduction: Osteoprotegerin (OPG) inhibits vascular calcification which is central to pathogenesis of arterial stiffness. However, it promotes inflammation by upregulating expression of vascular cell adhesion molecule-1(VCAM-1), thereby …
View article: Incident heart failure and the subsequent risk of progression to end stage kidney disease in individuals with type 2 diabetes
Incident heart failure and the subsequent risk of progression to end stage kidney disease in individuals with type 2 diabetes Open
Background Diabetic kidney disease is an established risk factor for heart failure. However, the impact of incident heart failure on the subsequent risk of renal failure has not been systematically assessed in diabetic population. We sough…
View article: Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes
Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes Open
Circulating ceramide levels are dysregulated in kidney disease. However, their associations with rapid decline in kidney function (RDKF) and end-stage kidney disease (ESKD) in patients with type 2 diabetes (T2D) are unknown. In this prospe…
View article: Plasma Proteomics of Diabetic Kidney Disease Among Asians With Younger-Onset Type 2 Diabetes
Plasma Proteomics of Diabetic Kidney Disease Among Asians With Younger-Onset Type 2 Diabetes Open
Context Patients with younger onset of type 2 diabetes (YT2D) have increased risk for kidney failure compared to those with late onset. However, the mechanism of diabetic kidney disease (DKD) progression in this high-risk group is poorly u…
View article: Urine Tricarboxylic Acid Cycle Metabolites and Risk of End-stage Kidney Disease in Patients With Type 2 Diabetes
Urine Tricarboxylic Acid Cycle Metabolites and Risk of End-stage Kidney Disease in Patients With Type 2 Diabetes Open
Context Metabolites in the tricarboxylic acid (TCA) pathway have pleiotropic functions. Objective To study the association between urine TCA cycle metabolites and the risk for chronic kidney disease progression in individuals with type 2 d…
View article: Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes
Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes Open
Background Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in pa…
View article: Association Between Kidney Disease Index and Decline in Cognitive Function with Mediation by Arterial Stiffness in Asians with Type 2 Diabetes
Association Between Kidney Disease Index and Decline in Cognitive Function with Mediation by Arterial Stiffness in Asians with Type 2 Diabetes Open
Background: Decline in renal function impairs systemic clearance of amyloid-β which characterizes Alzheimer’s disease while albuminuria is associated with blood-brain barrier disruption due to endothelial damage. Arterial stiffness adverse…
View article: ASSOCIATION BETWEEN FATTY LIVERLINKED LYPLAL1 RS12137855 AND DEPRESSION IN TYPE 2 DIABETES
ASSOCIATION BETWEEN FATTY LIVERLINKED LYPLAL1 RS12137855 AND DEPRESSION IN TYPE 2 DIABETES Open
INTRODUCTIONLimited data, predominantly cross-sectional, suggest an association between non-alcoholic fatty liver disease (NAFLD) and depression. Whether NAFLD-associated genetic variants are associated with depressive symptoms is not clea…
View article: ASSOCIATION BETWEEN GLYCEMIC VARIABILITY AND LOWER COGNITIVE FUNCTION, MEDIATED BY ARTERIAL STIFFNESS, IN ASIANS WITH TYPE 2 DIABETES
ASSOCIATION BETWEEN GLYCEMIC VARIABILITY AND LOWER COGNITIVE FUNCTION, MEDIATED BY ARTERIAL STIFFNESS, IN ASIANS WITH TYPE 2 DIABETES Open
INTRODUCTIONGlycemic variability involves deleterious cellular processes due to hyperglycemic spikes and hypoglycemic troughs. It is a known predictor of renal, retinal, and cardiovascular complications in type 2 diabetes (T2D). However, i…
View article: Longitudinal profiling and tracking stability in the Singapore study of macro-angiopathy and microvascular reactivity in type 2 diabetes cohort
Longitudinal profiling and tracking stability in the Singapore study of macro-angiopathy and microvascular reactivity in type 2 diabetes cohort Open
Introduction The Singapore Study of Macro-Angiopathy and microvascular Reactivity in Type 2 Diabetes (SMART2D) is a prospective cohort study which was started in 2011 to investigate the effect of risk factors on vascular function and diabe…
View article: Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes
Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: We sought to study the associations between plasma metabolites in tryptophan-kynurenine pathway and the risk of progression to end stage kidney disease (ESKD) in patients with type 2 diabetes. Design and Methods: Plasma tryptoph…
View article: Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes Open
OBJECTIVE We sought to study the associations between plasma metabolites in the tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease (ESKD) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Plas…
View article: Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes
Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: We sought to study the associations between plasma metabolites in tryptophan-kynurenine pathway and the risk of progression to end stage kidney disease (ESKD) in patients with type 2 diabetes. Design and Methods: Plasma tryptoph…
View article: Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients
Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients Open
Introduction: Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is the angle of vector determined by the body’s resistance and reactance. It indicates cellular integrity and hydration status. Though extracellular volu…
View article: Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population
Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population Open
TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.
View article: Incident heart failure and the subsequent risk for progression to end stage kidney disease in South East Asian people with type 2 diabetes
Incident heart failure and the subsequent risk for progression to end stage kidney disease in South East Asian people with type 2 diabetes Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Singapore National Medical Research Council grants: CSA-INV/0020/2017 and CS-IRG (MOH-000066) Background Heart failure (HF) i…
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes
Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes Open
OBJECTIVE Leucine-rich α-2 glycoprotein 1 (LRG1) was recently identified as an amplifier of transforming growth factor-β (TGF-β)–induced kidney fibrosis in animal models. We aimed to study whether urine LRG1 is associated with risk of prog…
View article: ASSOCIATION BETWEEN ELEVATED PHASE ANGLE AND REDUCED RISK OF CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES
ASSOCIATION BETWEEN ELEVATED PHASE ANGLE AND REDUCED RISK OF CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES Open
OBJECTIVESPhase angle (PhA) is a bioelectrical impedance analysis parameter defined as the angle of the vector formed by the body’s resistance and reactance. It indicates nutritional status, with higher levels signifying healthier cell mem…
View article: ASSOCIATION OF HIF1A rs142179458 WITH BODY ADIPOSITY IN MULTI-ETHNIC ASIANS WITH TYPE 2 DIABETES
ASSOCIATION OF HIF1A rs142179458 WITH BODY ADIPOSITY IN MULTI-ETHNIC ASIANS WITH TYPE 2 DIABETES Open
OBJECTIVES Hypoxia is known to contribute to obesity and its related metabolic disorders. Our preliminary data derived from whole-exome sequencing suggested an association of the hypoxia-inducible factor 1 a (HIF1a) rs142179458 variant wit…
View article: ASSOCIATIONS OF NON-INVASIVE PARAMETERS OF LIVER STEATOSIS AND FIBROSIS WITH RENAL IMPAIRMENT IN TYPE 2 DIABETES
ASSOCIATIONS OF NON-INVASIVE PARAMETERS OF LIVER STEATOSIS AND FIBROSIS WITH RENAL IMPAIRMENT IN TYPE 2 DIABETES Open
OBJECTIVESWe examined the associations of non-invasive parameters of liver steatosis and fibrosis with renal impairment, and the mediatory role of the pro-angiogenic factor leucine-rich α-2 glycoprotein 1 (LRG). METHODOLOGYAdults with type…