Kevin B. Givechian
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View article: Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis
Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis Open
Breast and body contouring procedures are plastic surgery’s most popular and effective interventions. Although these procedures are generally safe, they are not without risks and complications. Antifibrinolytic drugs such as tranexamic aci…
View article: ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties
ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties Open
Epitope-based vaccines are promising therapeutic modalities for infectious diseases and cancer, but identifying immunogenic epitopes is challenging. The vast majority of prediction methods only use amino acid sequence information, and do n…
View article: ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties
ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties Open
Epitope-based vaccines are promising therapeutic modalities for infectious diseases and cancer, but identifying immunogenic epitopes is challenging. The vast majority of prediction methods only use amino acid sequence information, and do n…
View article: Recent Trends and Future Directions for the Integrated Plastic Surgery Match
Recent Trends and Future Directions for the Integrated Plastic Surgery Match Open
Summary: The integrated plastic surgery residency match has risen to be the most competitive specialty in the 2022 match. This reality has prompted medical students to reach a high level of personal achievements, including pursuing researc…
View article: ReLSO: A Transformer-based Model for Latent Space Optimization and Generation of Proteins
ReLSO: A Transformer-based Model for Latent Space Optimization and Generation of Proteins Open
The development of powerful natural language models have increased the ability to learn meaningful representations of protein sequences. In addition, advances in high-throughput mutagenesis, directed evolution, and next-generation sequenci…
View article: Multimodal Analysis Reveals Differential Immuno-Metabolic Features in Lung Squamous Cell Carcinoma and Adenocarcinoma
Multimodal Analysis Reveals Differential Immuno-Metabolic Features in Lung Squamous Cell Carcinoma and Adenocarcinoma Open
Background The relationship between systemic metabolism, immune function, and lung cancer is complex and remains poorly defined. Seemingly paradoxically, overweight and obesity confer an improved response to immune checkpoint inhibition in…
View article: Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression
Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression Open
Background The interplay between glycolysis and immunosuppression in cancer has recently emerged as an intriguing area of research. The aim of this study was to elucidate a potential epigenetic link between glycolysis, isocitrate hydrogena…
View article: Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity Open
DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. To gain insight into chromatin state across existing tumor data, we improved neural network models for pre…
View article: An immunogenic NSCLC microenvironment is associated with favorable survival in lung adenocarcinoma
An immunogenic NSCLC microenvironment is associated with favorable survival in lung adenocarcinoma Open
The tumor microenvironment consists of an intricately organized system through which immune cells and cancer cells may communicate to regulate anti-tumor immunogenicity. To this end, non-small cell lung cancer (NSCLC) has been shown to act…
View article: Deep Learning with Implicit Handling of Tissue-Specific Phenomena Predicts Tumor DNA Accessibility and Immune Activity
Deep Learning with Implicit Handling of Tissue-Specific Phenomena Predicts Tumor DNA Accessibility and Immune Activity Open
View article: CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma
CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma Open
Somatic mutations in DNA repair genes have been clinically associated with chemosensitivity, although few studies have interrogated the nucleotide synthesis pathways that supply DNA repair processes. Previous work suggests that bladder uro…
View article: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples Open
View article: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples Open
Immune heterogeneity within the tumor microenvironment undoubtedly adds several layers of complexity to our understanding of drug sensitivity and patient prognosis across various cancer types. Within the tumor microenvironment, immunogenic…
View article: Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activity
Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activity Open
DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. Recently, neural networks have begun to make it possible to explore the impact of mutations on DNA accessi…
View article: Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma Open
Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex heterogeneous disease reflecte…
View article: Additional file 1: Table S1. of Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Additional file 1: Table S1. of Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma Open
Summary of Gene Product Overexpression/Underexpression in MM & Pre MM. (ZIP 294Â kb)