Kevin Bersell
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View article: Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization Open
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family …
View article: Isolation and Characterization of Intact Cardiomyocytes from Frozen and Fresh Human Myocardium and Mouse Hearts
Isolation and Characterization of Intact Cardiomyocytes from Frozen and Fresh Human Myocardium and Mouse Hearts Open
View article: Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes
Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes Open
Fluorescence recovery after photobleaching (FRAP) has been useful in delineating cardiac myofilament biology, and innovations in fluorophore chemistry have expanded the array of microscopic assays used. However, one assumption in FRAP is t…
View article: Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes
Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes Open
View article: Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy
Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy Open
View article: Highlights From the <i>Circulation</i> Family of Journals
Highlights From the <i>Circulation</i> Family of Journals Open
BACKGROUND:The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear.Case reports, including the one we document here, demonstrate that azith…
View article: Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults
Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults Open
Using genome-wide association we identified a novel candidate susceptibility locus near PRDM2. Variation in genes belonging to pathways related to DNA repair, metabolism, and cardiac remodeling may influence changes in LV function after an…
View article: Azithromycin Causes a Novel Proarrhythmic Syndrome
Azithromycin Causes a Novel Proarrhythmic Syndrome Open
Background— The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear. Case reports, including the one we document here, demonstrate that azi…
View article: Generation and Characterization of a Human iPSC Cardiomyocyte Model of Troponin T I79N Linked Hypertrophic Cardiomyopathy
Generation and Characterization of a Human iPSC Cardiomyocyte Model of Troponin T I79N Linked Hypertrophic Cardiomyopathy Open
View article: Contrasting Nav1.8 Activity in <i>Scn10a</i> <sup> <i>−/−</i> </sup> Ventricular Myocytes and the Intact Heart
Contrasting Nav1.8 Activity in <i>Scn10a</i> <sup> <i>−/−</i> </sup> Ventricular Myocytes and the Intact Heart Open
Background Genome‐wide association studies have implicated variants in SCN 10A , which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has indicated the SCN 10A sequence includes an intronic enhancer for SCN 5A . Yet th…
View article: Partial Duplication and Poly(A) Insertion in <i>KCNQ1</i> Not Detected by Next-Generation Sequencing in Jervell and Lange–Nielsen Syndrome
Partial Duplication and Poly(A) Insertion in <i>KCNQ1</i> Not Detected by Next-Generation Sequencing in Jervell and Lange–Nielsen Syndrome Open