Kevin C. Flanagan
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View article: HD-EPIC: A Highly-Detailed Egocentric Video Dataset
HD-EPIC: A Highly-Detailed Egocentric Video Dataset Open
We present a validation dataset of newly-collected kitchen-based egocentric videos, manually annotated with highly detailed and interconnected ground-truth labels covering: recipe steps, fine-grained actions, ingredients with nutritional v…
View article: Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma
Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma Open
View article: Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study
Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study Open
Background Despite advances in cancer care and detection, >65% of patients with squamous cell cancer of the head and neck (HNSCC) will develop recurrent and/or metastatic disease. The prognosis for these patients is poor with a 5-year over…
View article: Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma
Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma Open
Background While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15–20% benefit from such treatments. Clinic…
View article: Multicenter validation of an assay to predict anti-PD-1 disease control in patients with recurrent or metastatic Head and Neck Squamous Cell Carcinoma: The PREDAPT Study
Multicenter validation of an assay to predict anti-PD-1 disease control in patients with recurrent or metastatic Head and Neck Squamous Cell Carcinoma: The PREDAPT Study Open
Background Despite advances in cancer care and detection, more than 65% of patients with squamous cell cancer of the head and neck (HNSCC) will develop recurrent and/or metastatic disease. The prognosis for these patients is poor with a 5 …
View article: Video Editing for Video Retrieval
Video Editing for Video Retrieval Open
Though pre-training vision-language models have demonstrated significant benefits in boosting video-text retrieval performance from large-scale web videos, fine-tuning still plays a critical role with manually annotated clips with start an…
View article: Learning Temporal Sentence Grounding From Narrated EgoVideos
Learning Temporal Sentence Grounding From Narrated EgoVideos Open
The onset of long-form egocentric datasets such as Ego4D and EPIC-Kitchens presents a new challenge for the task of Temporal Sentence Grounding (TSG). Compared to traditional benchmarks on which this task is evaluated, these datasets offer…
View article: Multidimensional biomarker predicts disease control in response to immunotherapy in recurrent or metastatic head and neck squamous-cell carcinoma
Multidimensional biomarker predicts disease control in response to immunotherapy in recurrent or metastatic head and neck squamous-cell carcinoma Open
View article: Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
Neoplastic cells rely on the tumor microenvironment (TME) for survival and progression factors. Indeed, senescent and cancer-associated fibroblasts (CAF) express factors that promote tumorigenesis that are collectively referred to as the s…
View article: Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 62K, legends for supplemental figures
View article: Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 401K, List of p38MAPK-dependent SASP factors and their overlap with publically available expression analyses from breast cancer-associated microenvironments
View article: Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 229K, qRT-PCR validation of RNA-seq analysis and TNFalpha ELISA on p38i treated mice
View article: Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Table 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 401K, List of p38MAPK-dependent SASP factors and their overlap with publically available expression analyses from breast cancer-associated microenvironments
View article: Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Data from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
Neoplastic cells rely on the tumor microenvironment (TME) for survival and progression factors. Indeed, senescent and cancer-associated fibroblasts (CAF) express factors that promote tumorigenesis that are collectively referred to as the s…
View article: Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 3 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 229K, qRT-PCR validation of RNA-seq analysis and TNFalpha ELISA on p38i treated mice
View article: Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 545K, SASP upregulation following bleomycin, NaB or replication-induced senescence. SASP mRNA stabilization in NaB-treated BJs and in bleomycin-treated IMR90s
View article: Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 194K, Senescence-associated beta-galactosidase staining of BJ fibroblasts and treatment of HaCaT-CBR cells with the p38MAPK small-molecule inhibitor SB203580
View article: Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure Legends from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 62K, legends for supplemental figures
View article: Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 545K, SASP upregulation following bleomycin, NaB or replication-induced senescence. SASP mRNA stabilization in NaB-treated BJs and in bleomycin-treated IMR90s
View article: Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Supplementary Figure 1 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis Open
PDF file 194K, Senescence-associated beta-galactosidase staining of BJ fibroblasts and treatment of HaCaT-CBR cells with the p38MAPK small-molecule inhibitor SB203580
View article: Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open
The role of the stromal compartment in tumor progression is best illustrated in breast cancer bone metastases, where the stromal compartment supports tumor growth, albeit through poorly defined mechanisms. p38MAPKα is frequently expressed …
View article: Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open
Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
View article: Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Purpose:To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.Experimental Design:Paired pre- and po…
View article: Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Purpose:To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.Experimental Design:Paired pre- and po…
View article: Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
View article: Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
View article: Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open
Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
View article: Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
View article: Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Open
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
View article: Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open
The role of the stromal compartment in tumor progression is best illustrated in breast cancer bone metastases, where the stromal compartment supports tumor growth, albeit through poorly defined mechanisms. p38MAPKα is frequently expressed …