Explanipedia

Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in Tanzania Open

Matthew D. Barberio, Kevin C. Klatt, Sabina Mugusi, Mathangi Gopalakrishnan, Zohra Lukmanji , et al. · 2025

Background Vitamin B12 is an essential cofactor for two enzymes that have critical functions in pregnancy, both for maternal health and fetal development. However, the optimal supplemental dosage and its correlation with vitamin B12 statu…

A Genome-Wide Association Study of Circulating Serum Choline, Betaine, Dimethylglycine, and Their Ratios Open

Lauren E Louck, Kevin C. Klatt, Taylor C. Wallace, Jiantao Ma, Mei Chung · 2025

Background/Objectives: Genetic variation has been thought to alter the human dietary requirement for choline and subsequent circulating levels of its metabolites betaine and dimethylglycine (DMG). The aim of this genome-wide association st…

Make America Healthy, Again? The Past, Present and Future of Dietary Guidelines Open

Kevin C. Klatt · 2025

Dietary guidelines have been placed under unprecedented scrutiny in the past decade, as the “obesity epidemic” enters its fifth decade with limited evidence of public health progress. In the era of successful obesity pharmacotherapy, there…

Single-Blinded, Stratified, Dose Ranging Trial to Assess Pharmacokinetics and Identify Optimal Dose of Vitamin B12 in Pregnancy in Tanzania Open

Omar Lweno, Homa K. Ahmadzia, Fadhlun M. Alwy Al‐beity, Amrita Arcot, Matthew D. Barberio , et al. · 2025

Relationship of Choline Intake with Biomarkers of Liver Health by Genotype–A Cross-Sectional Analysis Open

Taylor C. Wallace, Alexandra E Cowan-Pyle, Kevin C. Klatt, Regan L Bailey · 2025

In this exploratory NHANES analysis, self-reported choline intakes were not associated with worsening circulating liver function biomarkers in the study population as a whole or when stratified by genotype. Our findings did not recapitulat…

Nutrition Users’ Guides: an introduction to structured guides to evaluate the nutrition literature Open

Bradley C. Johnston, Mary Rozga, Gordon H Guyatt, Rosa K. Hand, Deepa Handu , et al. · 2025

Despite evidence that nutrition can play a substantial role in curbing the burden of chronic disease, findings reported in the nutrition literature have been plagued with debate and uncertainty, including questions about the confidence we …

Choline metabolites and 15-year risk of incident diabetes in a prospective cohort of adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study Open

Jessica Sprinkles, Anju Lulla, Autumn G. Hullings, Isis Trujillo‐Gonzalez, Kevin C. Klatt , et al. · 2024

Objective The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted samples of older age ad…

Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study Open

Jessica Sprinkles, Anju Lulla, Autumn G. Hullings, Isis Trujillo‐Gonzalez, Kevin C. Klatt , et al. · 2024

OBJECTIVE The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted in samples of older adu…

Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in Tanzania Open

Omar Lweno, Victoria Reynolds, Matthew D. Barberio, Kevin C. Klatt, Sabina Mugusi , et al. · 2024

Background Vitamin B12 is an essential cofactor for two enzymes that have critical functions in pregnancy, both for maternal health and fetal development. However, the optimal supplemental dosage and its correlation with vitamin B12 status…

Nutrition Users’ Guides: RCTs Part 2 – structured guide for interpreting and applying study results from randomised controlled trials on therapy or prevention questions Open

Małgorzata M Bała, Arnav Agarwal, Kevin C. Klatt, Robin W.M. Vernooij, Pablo Alonso‐Coello , et al. · 2024

This article continues from a prior commentary on evaluating the risk of bias in randomised controlled trials addressing nutritional interventions. Having provided a synopsis of the risk of bias issues, we now address how to understand tri…

Dietary choline and betaine intake minimally impacts rate of annualized cognitive performance throughout the menopause transition: data from the Study of Women's Health Across the Nation Open

Alexandra E Cowan-Pyle, Taylor C. Wallace, Kevin C. Klatt, Margaret Slavin, Regan L Bailey · 2024

Objective Dietary choline is associated with lower risk of dementia in older adults, yet this association during mid-life remains unknown. Given that menopause reflects a nutrition-sensitive time point where prevention strategies may mitig…

Nutrition users’ guides: RCTs part 1 – structured guide for assessing risk of bias in randomised controlled trials that address therapy or prevention questions Open

Arnav Agarwal, Małgorzata M Bała, Dena Zeraatkar, Claudia Valli, Pablo Alonso‐Coello , et al. · 2024

The purpose of this article, part 1 of 2 on randomised controlled trials (RCTs), is to provide readers (eg, clinicians, patients, health service and policy decision-makers) of the nutrition literature structured guidance on interpreting RC…

A Genome-Wide Association Study of Serum Choline and Related-Metabolites Open

Lauren E Louck, Taylor C. Wallace, Kevin C. Klatt, Jiantao Ma, Mei Chung · 2024

Objectives: Common single nucleotide polymorphisms (SNPs) in one-carbon metabolism have been shown to influence the dietary requirement for choline in humans. The aim of the study was to identify SNPs associated with serum choline levels, …

Examining Correlations Between Plasma Volume, Hydration, and Anemia Biomarkers in Pregnant Women in Tanzania Open

Leigh A Martin, Amrita Arcot, Kelly Gallagher, Matthew D. Barberio, Kevin C. Klatt , et al. · 2024

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges Open

Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi , et al. · 2024

Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discus…

Maternal Vitamin B12 in Pregnancy and Placental Development Open

Amrita Arcot, Rachel E. Walker, Kelly Gallagher, Kevin C. Klatt, Alison D. Gernand · 2024

Vitamin B12, or cobalamin, is an essential nutrient required for diverse physiological functions secondary to its role as a critical cofactor for two mammalian enzymes, methionine synthase and methylmalonyl‐CoA mutase. While essential thro…

Evidence-Based Practice Competencies among Nutrition Professionals and Students: A Systematic Review Open

Nirjhar Ghosh, Zahra Esmaeilinezhad, J. Zając, Rebecca A Creasy, Saundra G. Lorenz , et al. · 2023

The Relationship of Circulating Choline and Choline-Related Metabolite Levels with Health Outcomes: A Scoping Review of Genome-Wide Association Studies and Mendelian Randomization Studies Open

Lauren E Louck, Kelly Copeland Cara, Kevin C. Klatt, Taylor C. Wallace, Mei Chung · 2023

Choline is essential for proper liver, muscle, brain, lipid metabolism, cellular membrane composition, and repair. Understanding genetic determinants of circulating choline metabolites can help identify new determinants of choline metaboli…

Evidence-Based Practice Competencies among Nutrition Professionals and Students: A Systematic Review Open

Nirjhar Ghosh, Zahra Esmaeilinezhad, J. Zając, Rebecca A Creasy, Saundra G. Lorenz , et al. · 2023

Background Evidence-based practice (EBP) promotes shared decision-making between clinicians and patients and has been widely adopted by various health professions including nutrition & dietetics, medicine and nursing. Objective To determin…

P10-019-23 Impact of Genetically Predicted Circulating Choline Levels on Health Outcomes: A Scoping Review Open

Lauren E Louck, Kelly Copeland Cara, Taylor C. Wallace, Kevin C. Klatt, Mei Chung · 2023

Chowing down: diet considerations in rodent models of metabolic disease Open

Kevin C. Klatt, Kevin Bass, John R. Speakman, Kevin D. Hall · 2023

Diet plays a substantial role in the etiology, progression, and treatment of chronic disease and is best considered as a multifaceted set of modifiable input variables with pleiotropic effects on a variety of biological pathways spanning m…

LRH-1 induces hepatoprotective nonessential amino acids in response to acute liver injury Open

Kevin C. Klatt, Elizabeth J. Petviashvili, David D. Moore · 2023

Acute hepatic injury is observed in response to various stressors, including trauma, ingestion of hepatic toxins, and hepatitis. Investigations to date have focused on extrinsic and intrinsic signals required for hepatocytes to proliferate…

A Cross-Sectional Analysis of Products Marketed as Plant-Based Across the United States, United Kingdom, and Canada Using Online Nutrition Information Open

Nicola Guess, Kevin C. Klatt, Dorothy Wei, Eric Williamson, Ilayda Ulgenalp , et al. · 2023

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges Open

Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi , et al. · 2022

Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discus…

Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis Open

Aura P. Loinard-González, Olga Malysheva, Kevin C. Klatt, Marie A. Caudill · 2022

The delivery of docosahexanoic acid (DHA) to the fetus is dependent on maternal one-carbon metabolism, as the latter supports the hepatic synthesis and export of a DHA-enriched phosphatidylcholine molecule via the phosphatidylethanolamine …

Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid (DHA) status among pregnant participants consuming supplemental DHA: a randomized controlled trial Open

Kevin C. Klatt, Melissa McDougall, Olga Malysheva, Siraphat Taesuwan, Aura P. Loinard-González , et al. · 2022

Prenatal choline supplementation improves hepatic DHA export and biomarkers of DHA status by bolstering methyl group supply for PEMT activity among pregnant participants consuming supplemental DHA. This trial is registered at www.clinicalt…

A cross-sectional study of the commercial plant-based landscape across the US, UK and Canada Open

Nicola Guess, Kevin C. Klatt, Dorothy Wei, Eric Williamson, Ilayda Ulgenalp , et al. · 2022

As plant-based foods comprise an ever-increasing proportion of the diet, understanding the nutritional composition of these products is critical. In this study we assess the nutritional content of all commercial plant-based products across…

Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement Open

Danielle Belardo, Erin D. Michos, Ron Blankstein, Roger S. Blumenthal, Keith C. Ferdinand , et al. · 2022

One-carbon metabolism in children with marasmus and kwashiorkor Open

Thaddaeus May, Bethany de la Haye, Gabrielle Nord, Kevin C. Klatt, Kevin Stephenson , et al. · 2022

Perspective: Estrogen and the Risk of Cognitive Decline: A Missing Choline(rgic) Link? Open

Jonathan Bortz, Kevin C. Klatt, Taylor C. Wallace · 2021

Factors that influence the risk of neurocognitive decline and Alzheimer's disease (AD) may provide insight into therapies for both disease treatment and prevention. Although age is the most striking risk factor for AD, it is notable that t…

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