Kevin Chapman
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View article: Streamlining Spatial Transcriptomics for Human Kidney Tissue
Streamlining Spatial Transcriptomics for Human Kidney Tissue Open
Single-cell spatial technologies have emerged in recent years, enabling tissue architecture and organization characterization at unprecedented resolution. However, computational analysis of spatial transcriptomics data is often a bottlenec…
View article: Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members
Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members Open
Despite the importance of timeliness in SE management, one third of institutional protocols did not specify treatment times. This analysis of US hospital inpatient SE protocols provides expert opinion regarding infusion therapy management …
View article: Epilepsy monitoring unit practices and safety among NAEC epilepsy centers: A census survey
Epilepsy monitoring unit practices and safety among NAEC epilepsy centers: A census survey Open
View article: Unmet needs in epileptic encephalopathy with spike-and-wave activation in sleep: A systematic review
Unmet needs in epileptic encephalopathy with spike-and-wave activation in sleep: A systematic review Open
Long-term cognitive deficits remain common in D/EE-SWAS, and data gaps exist in the literature that preclude an evidence-based approach to managing this complex epilepsy indication. Early intervention with more effective medications is nee…
View article: Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children Open
This study provides Class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures.
View article: Survey of Pediatric ICU EEG Monitoring–Reassessment After a Decade
Survey of Pediatric ICU EEG Monitoring–Reassessment After a Decade Open
Purpose: In 2011, the authors conducted a survey regarding continuous EEG (CEEG) utilization in critically ill children. In the interim decade, the literature has expanded, and guidelines and consensus statements have addressed CEEG utiliz…
View article: Associations between testing and treatment pathways in lesional temporal or extratemporal epilepsy: A census survey of NAEC center directors
Associations between testing and treatment pathways in lesional temporal or extratemporal epilepsy: A census survey of NAEC center directors Open
Objective The evaluation to determine candidacy and treatment for epilepsy surgery in persons with drug‐resistant epilepsy (DRE) is not uniform. Many non‐invasive and invasive tests are available to ascertain an appropriate treatment strat…
View article: Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques
Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques Open
Epilepsy surgery procedure volumes are influenced by US epilepsy center region and other characteristics. These variations may affect access to specific surgical treatments for persons with drug resistant epilepsy across the United States.
View article: Epilepsy center characteristics and geographic region influence presurgical testing in the United States
Epilepsy center characteristics and geographic region influence presurgical testing in the United States Open
Objective Persons with drug‐resistant epilepsy may benefit from epilepsy surgery and should undergo presurgical testing to determine potential candidacy and appropriate intervention. Institutional expertise can influence use and availabili…
View article: Impact of the COVID-19 Pandemic on Epilepsy Center Practice in the United States
Impact of the COVID-19 Pandemic on Epilepsy Center Practice in the United States Open
In the US, access to care for persons with epilepsy declined during the COVID-19 pandemic in 2020. Adult patients, those relying on level 3 centers for care, and many persons in the eastern half of the US were most affected.
View article: United States Epilepsy Center Characteristics
United States Epilepsy Center Characteristics Open
During the study period, the availability of specialty epilepsy care in the United States improved as the NAEC implemented its accreditation program. Surgical case complexity increased while aggregate surgical volume remained stable or dec…
View article: Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy
Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy Open
Purpose: Up to half of the children undergoing epilepsy surgery will continue to have seizures (szs) despite a cortical resection or ablation. Functional connectivity has shown promise in better identifying the epileptogenic zone. We hypot…
View article: Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus
Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus Open
Objective This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non‐BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). Methods Th…
View article: Factors associated with long‐term outcomes in pediatric refractory status epilepticus
Factors associated with long‐term outcomes in pediatric refractory status epilepticus Open
Objective This study was undertaken to describe long‐term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE. Methods We performed r…
View article: Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort) Open
Objective We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). Methods Patients with r…
View article: Treatment Practices and Outcomes in Continuous Spike and Wave during Slow Wave Sleep: A Multicenter Collaboration
Treatment Practices and Outcomes in Continuous Spike and Wave during Slow Wave Sleep: A Multicenter Collaboration Open
View article: Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation
Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation Open
Background and Aims Thrombin levels in the colon of Crohn’s disease patients have recently been found to be elevated 100-fold compared with healthy controls. Our aim was to determine whether and how dysregulated thrombin activity could con…
View article: First-line medication dosing in pediatric refractory status epilepticus
First-line medication dosing in pediatric refractory status epilepticus Open
This study provides Class III evidence that patients with RSE who present with male sex, older age, no prior diagnosis of epilepsy, and delayed BZD treatment are more likely to receive low total BZD doses. This study provides Class III evi…
View article: Association of guideline publication and delays to treatment in pediatric status epilepticus
Association of guideline publication and delays to treatment in pediatric status epilepticus Open
Publication of evidence on delays in time to treatment was not associated with improvements in time to treatment of rSE, although it was associated with an increase in the proportion of patients who received at least 1 BZD before hospital …
View article: Spike‐associated networks and intracranial electrographic findings
Spike‐associated networks and intracranial electrographic findings Open
Aims . Functional connectivity is providing new insights into the network nature of epilepsy with growing clinical applications. Our objective was to validate a novel magnetoencephalography‐based method to non‐invasively measure the epilep…
View article: American Epilepsy Society (AES): Written Comments to Norman E. “Ned” Sharpless, MD, Acting Commissioner of Food and Drugs, U.S. Food and Drug Administration (FDA), Department of Health and Human Services (HHS)
American Epilepsy Society (AES): Written Comments to Norman E. “Ned” Sharpless, MD, Acting Commissioner of Food and Drugs, U.S. Food and Drug Administration (FDA), Department of Health and Human Services (HHS) Open
View article: Prospective evaluation of oral cannabis extracts in children with epilepsy
Prospective evaluation of oral cannabis extracts in children with epilepsy Open
View article: The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies
The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies Open
Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily i…
View article: Highlights From the Annual Meeting of the American Epilepsy Society 2018
Highlights From the Annual Meeting of the American Epilepsy Society 2018 Open
The American Epilepsy Society Meeting in New Orleans attracted more than 5900 attendees. There was a lively exchange of new science, innovation, education, clinical practice, and many other items related to epilepsy. Educational symposia w…
View article: The impact of cannabis use on intracarotid amobarbital testing
The impact of cannabis use on intracarotid amobarbital testing Open
View article: Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers
Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers Open
The pSERG hospitals status epilepticus pathways are consistent with the AES status epilepticus guideline in regard to the choice of medications, but generally recommend more rapid escalation in therapy than the guideline.
View article: Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device
Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device Open
View article: Factors associated with treatment delays in pediatric refractory convulsive status epilepticus
Factors associated with treatment delays in pediatric refractory convulsive status epilepticus Open
Intermittent rSE and out-of-hospital rSE onset are independently associated with longer delays to administration of the first BZD and the first non-BZD AED in pediatric rSE. These factors identify potential targets for intervention to redu…
View article: Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus
Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus Open
Among pediatric patients with RCSE, an untimely first-line benzodiazepine treatment is independently associated with a higher frequency of death, use of continuous infusions, longer convulsion duration, and more frequent hypotension. Resul…
View article: Response to clobazam in continuous spike‐wave during sleep
Response to clobazam in continuous spike‐wave during sleep Open
Aim To evaluate the efficacy of clobazam treatment in reducing epileptiform discharges and modifying neuropsychological function in continuous spike‐wave during slow wave sleep. Method We performed a prospective clinical trial in patients …