Kevin D. Daze
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View article: Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes Open
Plant homeodomain (PHD) finger-containing proteins are implicated in fundamental biological processes, including transcriptional activation and repression, DNA damage repair, cell differentiation, and survival. The PHD finger functions as …
View article: Rational Adaptation of L3MBTL1 Inhibitors to Create Small‐Molecule Cbx7 Antagonists
Rational Adaptation of L3MBTL1 Inhibitors to Create Small‐Molecule Cbx7 Antagonists Open
Chromobox homolog 7 (Cbx7) is an epigenetic modulator that is an important driver of multiple cancers. It is a methyl reader protein that operates by recognizing and binding to methylated lysine residues on specific partners. Herein we rep…
View article: Molecular Interaction and Recognition
Molecular Interaction and Recognition Open
This chapter shows some examples on how interactions that are very weak can have profound influences on molecular recognition. The behavior of all biomolecules, materials, and medicinal agents is determined at some level by their ability t…
View article: Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids
Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids Open
We report a family of like-charged molecules that assemble in water and get stronger in high salt.
View article: CCDC 1033560: Experimental Crystal Structure Determination
CCDC 1033560: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family
Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family Open
The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on "aromatic cage" motifs to engage their partners' methyllysine side chains. Each CBX carries out distinct functions, yet each includes a highly simil…
View article: Author Index
Author Index Open
View article: Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes Open
Plant homeodomain (PHD) finger-containing proteins are implicated in fundamental biological processes, including transcriptional activation and repression, DNA damage repair, cell differentiation, and survival. The PHD finger functions as …