Kevin D. Costa
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View article: Design and implementation of a Targeted HealthcaRe InnoVation & Entrepreneurship (THRIVE) fellowship program
Design and implementation of a Targeted HealthcaRe InnoVation & Entrepreneurship (THRIVE) fellowship program Open
The Targeted HealthcaRe InnoVation & Entrepreneurship (THRIVE) Fellowship was created to bridge the gap between healthcare professionals, who often lack experience in technology development and entrepreneurship, and engineers or technology…
View article: Abortamento Voluntário, os Desafios e Dores de Mulheres e Cuidado de Enfermagem
Abortamento Voluntário, os Desafios e Dores de Mulheres e Cuidado de Enfermagem Open
View article: Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 Open
View article: Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms
Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms Open
Cardiovascular disease stands as the leading cause of death globally, claiming approximately 19million lives in 2020. On the contrary, the development of cardiovascular drugs is experiencing a decline, largely due to the bottleneck in unde…
View article: OS CUIDADOS DE ENFERMAGEM À MULHER NO CLIMATÉRIO
OS CUIDADOS DE ENFERMAGEM À MULHER NO CLIMATÉRIO Open
O climatério é o período que engloba o primeiro ano da menopausa, que ocorre devido a alteração hormonal (diminuição dos níveis de estrógeno e progesterona) onde a mulher passa do período reprodutivo para o não reprodutivo, provocando sint…
View article: Enhanced drug classification using machine learning with multiplexed cardiac contractility assays
Enhanced drug classification using machine learning with multiplexed cardiac contractility assays Open
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead comp…
View article: Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia
Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia Open
View article: Regenerative potential of mouse neonatal intervertebral disc depends on collagen crosslink density
Regenerative potential of mouse neonatal intervertebral disc depends on collagen crosslink density Open
View article: Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial
Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial Open
Aims Heart failure with preserved ejection fraction (HFpEF), is a global health problem lacking disease-modifying therapeutic options, reflecting a lack of predictive models for preclinical drug testing. Aligned with FDA Modernization Act …
View article: Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 Open
Glioblastoma (GBM) is a malignant brain tumor with uncontrolled invasive growth. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 to gain biomechanical plasticity for polarized migration through confined space. Using li…
View article: Auxetic patch material exhibits systolic thickening and restores pump function in a finite element model of acute myocardial infarction repair
Auxetic patch material exhibits systolic thickening and restores pump function in a finite element model of acute myocardial infarction repair Open
Passive mechanical reinforcement of the infarcted heart has been shown to counteract infarct expansion and left ventricular (LV) functional degradation. However, traditional patch plasty of the ischemic region also restricts diastolic fill…
View article: STEM-01. PLEXIN-B2 DRIVES CONFINED MIGRATION OF GLIOBLASTOMA STEM CELLS THROUGH MEMBRANE TENSION, ENDOCYTOSIS, AND MECHANO-ELECTRO REGULATION
STEM-01. PLEXIN-B2 DRIVES CONFINED MIGRATION OF GLIOBLASTOMA STEM CELLS THROUGH MEMBRANE TENSION, ENDOCYTOSIS, AND MECHANO-ELECTRO REGULATION Open
Glioblastoma is a malignant brain tumor of uncontrolled proliferation and infiltration. GBM stem cells (GSCs) are constantly challenged by confined spaces during their migration through the brain parenchyma. Understanding the factors that …
View article: Automated Stimulation and Long-Term Remote Monitoring of Multi-Plex Microfluidic Organoid Chips
Automated Stimulation and Long-Term Remote Monitoring of Multi-Plex Microfluidic Organoid Chips Open
Developing a novel microfluidic organoid system required many experiments and iterations due to lack of knowledge about the relevant developmental biology. Collecting data on the developing organoids quickly escalated into a bottleneck as …
View article: Robotic System for Organoid Assembly in a Multi-Well Microfluidic Chip
Robotic System for Organoid Assembly in a Multi-Well Microfluidic Chip Open
While many cell culture systems are sensitive to the conditions in which cells are introduced into the system, we find that in situ differentiated tube-shaped microfluidic organoids have a particularly high sensitivity. Preliminary experim…
View article: Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome
Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome Open
Marfan Syndrome (MFS), a connective tissue disorder caused by a mutation in the fibrillin-1 gene, occurs in approximately 1 in 5,000 people worldwide. As an important constituent of the extracellular matrix, mutated fibrillin-1 in Marfan S…
View article: Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative
Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative Open
The rare genetic alteration PLN-c.(40_42delAGA), leading to the deletion of arginine 14 (p.R14del) in phospholamban, is associated with dilated and arrhythmogenic cardiomyopathies occurring in early-adulthood. However, some carriers remain…
View article: Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues
Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues Open
View article: Computational design of custom therapeutic cells to correct failing human cardiomyocytes
Computational design of custom therapeutic cells to correct failing human cardiomyocytes Open
Background: Myocardial delivery of non-excitable cells—namely human mesenchymal stem cells (hMSCs) and c-kit + cardiac interstitial cells (hCICs)—remains a promising approach for treating the failing heart. Recent empirical studies attempt…
View article: Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening
Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening Open
View article: Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms
Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms Open
Background: Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness is mediated by a mechanism differing from hypertension…
View article: PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes Open
View article: Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members
Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members Open
The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has been identified in families with hereditary cardiomyopathy, including dilated and arrhythmogenic cardiomyopathies. Here we have generated human iPSC lines from…
View article: Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact
Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact Open
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial bec…
View article: In silico Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium
In silico Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium Open
Myocardial delivery of human c-kit + cardiac interstitial cells (hCICs) and human mesenchymal stem cells (hMSCs), an emerging approach for treating the failing heart, has been limited by an incomplete understanding of the effects on host m…
View article: Rianú: Multi-Tissue Tracking Software for Increased Throughput of Engineered Cardiac Tissuescreening
Rianú: Multi-Tissue Tracking Software for Increased Throughput of Engineered Cardiac Tissuescreening Open
View article: Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues Open
View article: PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes Open
SUMMARY Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease. A major caveat however is that they remain functionally and structurally immature in culture,…
View article: 15000 Exploring team science, professional networks, and innovation success in the THRIVE COVID-19 fellowship program
15000 Exploring team science, professional networks, and innovation success in the THRIVE COVID-19 fellowship program Open
IMPACT: Implement and evaluate a fellowship program to foster a new generation of entrepreneurial and collaboratively-minded team scientists, equipped with the knowledge and skills to innovate technology-based solutions for COVID-19 to adv…
View article: Nanoindentation of iPSC-Derived Aortic Smooth Muscle Cells Reveals a Biomechanical and Developmental Basis for Aneurysm Localization in Marfan Syndrome
Nanoindentation of iPSC-Derived Aortic Smooth Muscle Cells Reveals a Biomechanical and Developmental Basis for Aneurysm Localization in Marfan Syndrome Open
View article: The THRIVE COVID-19 Fellowship: Creating a Forum for Collaborative Team Science and Innovation Development
The THRIVE COVID-19 Fellowship: Creating a Forum for Collaborative Team Science and Innovation Development Open
Purpose: Launched in October 2020, the Mount Sinai Targeted Healthcare Innovation Fellowship (THRIVE) is a 9-month program for participants from diverse professional backgrounds to form teams to develop a HealthTech innova…