Kevin Donnelly
YOU?
Author Swipe
View article: Advancing towards Large Marine Ecosystem sustainability
Advancing towards Large Marine Ecosystem sustainability Open
View article: Patient Impact of Surgery Abroad: A Retrospective Qualitative Analysis
Patient Impact of Surgery Abroad: A Retrospective Qualitative Analysis Open
Background With increasing international travel, more Northern Ireland (NI) residents are sustaining injuries abroad, sometimes requiring emergency orthopaedic surgery. Upon repatriation, the National Health Service (NHS) must address comp…
View article: Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models
Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models Open
A recent landmark study by the National Cancer Institute’s Children’s Oncology Group identified an independent association between childhood poverty and increased mortality rates in children with neuroblastoma, beyond known biological, acc…
View article: Uncovering the molecular signature of feline diffuse iris melanoma through transcriptomic analysis of disease severity
Uncovering the molecular signature of feline diffuse iris melanoma through transcriptomic analysis of disease severity Open
View article: Unravelling the Molecular Pathways of Feline Diffuse Iris Melanoma Progression
Unravelling the Molecular Pathways of Feline Diffuse Iris Melanoma Progression Open
Feline diffuse iris melanoma (FDIM) is the most common primary ocular tumour in cats, with high metastatic potential. Greater intraocular invasion correlates with increased mortality. No effective therapeutics exist for metastatic disease,…
View article: Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i> Open
Background Common genetic variation at 11q23.1 is associated with colorectal cancer (CRC) risk, exerting local expression quantitative trait locus (cis-eQTL) effects on POU2AF2 , COLCA1 and POU2AF3 genes. However, complex linkage disequili…
View article: Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes Open
View article: Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression Open
Inflammatory Bowel Disease-associated colorectal cancer (IBD-CRC) is a known and serious complication of Inflammatory Bowel Disease (IBD) affecting the colon. However, relatively little is known about the pathogenesis of IBD-associated col…
View article: Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes Open
View article: P076 Dock2 acts as a tumour suppressor via immune cell regulation of IDO1 in Inflammatory Bowel Disease–associated colorectal cancer
P076 Dock2 acts as a tumour suppressor via immune cell regulation of IDO1 in Inflammatory Bowel Disease–associated colorectal cancer Open
Background Inflammatory Bowel Disease-associated colorectal cancer (IBDCRC) is a known and serious complication of Inflammatory Bowel Disease (IBD) affecting the colon. However, relatively little is known about the pathogenesis of IBD-asso…
View article: Short-read whole genome sequencing identifies causative variants in most individuals with previously unexplained aniridia
Short-read whole genome sequencing identifies causative variants in most individuals with previously unexplained aniridia Open
Background Classic aniridia is a highly penetrant autosomal dominant disorder characterised by congenital absence of the iris, foveal hypoplasia, optic disc anomalies and progressive opacification of the cornea. >90% of cases of classic an…
View article: Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator<i>POU2AF2</i>
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator<i>POU2AF2</i> Open
Common genetic variation at 11q23.1 is associated with colorectal cancer (CRC) risk, and exerts local (cis) expression quantitative trait locus (cis-eQTL) effects on POU2AF2, COLCA1 and POU2AF3 genes. However, complex linkage disequilibriu…
View article: Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Open
View article: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Open
View article: Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium
Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium Open
Introduction Colorectal cancer (CRC) is the second most common cause of cancer death globally. Genome-wide association studies have established that cancer risk mediated through common genetic variants can be linked to variation in gene ex…
View article: Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico Open
View article: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries Open
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and Asian ancestry, identifying 205 independent ris…
View article: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries Open
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and Asian ancestry, identifying 205 independent ris…
View article: Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units
Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units Open
ISRCTN.org Identifier: ISRCTN60048867.
View article: Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression <i>in silico</i>
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression <i>in silico</i> Open
Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased colorectal cancer (CRC) risk, demonstrating eQTL effects on 3 cis- and 23 trans-eQ…
View article: Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney
Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney Open
Significance The Orcadian Neolithic has been intensively studied and celebrated as a major center of cultural innovation, whereas the Bronze Age is less well known and often regarded as a time of stagnation and insularity. Here, we analyze…
View article: Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation
Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation Open
Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which …
View article: Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects
Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects Open
Background The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determine whether oral vita…
View article: Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects
Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects Open
Background Risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in-vitro gene expression and cancer cell growth. We sought to determine whether oral vitamin …
View article: Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa
Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa Open
Site‐specific variation in colorectal cancer (CRC) incidence, biology and prognosis are poorly understood. We sought to determine whether common genetic variants influencing CRC risk might exhibit topographical differences on CRC risk thro…
View article: Digitising Swahili in Arabic Script With Andika!
Digitising Swahili in Arabic Script With Andika! Open
View article: Perceptions of education during COVID‐19 among agronomy, soil, and environmental science students
Perceptions of education during COVID‐19 among agronomy, soil, and environmental science students Open
The COVID‐19 pandemic required changes in college course delivery, which may influence student perceptions of their education. We examined those perceptions among Students of Agronomy, Soil, and Environmental Sciences (SASES). The goals we…
View article: Cryptic genetic variation and adaptation to waterlogging in Caledonian Scots pine, <i>Pinus sylvestris</i> L.
Cryptic genetic variation and adaptation to waterlogging in Caledonian Scots pine, <i>Pinus sylvestris</i> L. Open
Local adaptation occurs as the result of differential selection among populations. Observations made under common environmental conditions may reveal phenotypic differences between populations with an underlying genetic basis; however, exp…
View article: Early phenology and growth trait variation in closely related European pine species
Early phenology and growth trait variation in closely related European pine species Open
Closely related taxa occupying different environments are valuable systems for studying evolution. In this study, we examined differences in early phenology (bud set, bud burst) and early growth in a common garden trial of closely related …
View article: Managing extremely distal periprosthetic femoral supracondylar fractures of total knee replacements - a new PHILOS-ophy
Managing extremely distal periprosthetic femoral supracondylar fractures of total knee replacements - a new PHILOS-ophy Open
We report two cases where a proximal humeral locking plate was used for the fixation of an extremely distal, type III peri-prosthetic femoral fractures in relation to a total knee replacement (TKR). In each case there was concern regarding…