Kevin Dysart
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View article: High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-2024
High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-2024 Open
Introduction: Previous data demonstrate that pregnant individuals with sickle cell disease (SCD) face significantly elevated risks of severe maternal morbidity (SMM). Black individuals without SCD are also at high risk for SMM. A study of …
View article: The Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation
The Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation Open
Background Invasive mechanical ventilation contributes to bronchopulmonary dysplasia (BPD), the most common complication of prematurity and the leading respiratory cause of childhood morbidity. Non-invasive ventilation (NIV) may limit inva…
View article: 426 Brain natriuretic peptide testing and severe maternal morbidity in pregnancies affected by heart disease
426 Brain natriuretic peptide testing and severe maternal morbidity in pregnancies affected by heart disease Open
View article: Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants
Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants Open
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are associated with adverse neurologic outcomes in low-r…
View article: Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial
Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial Open
Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models.
View article: Changes in prenatal testing during the COVID-19 pandemic
Changes in prenatal testing during the COVID-19 pandemic Open
Objective The coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare delivery, including prenatal care. The study objective was to assess if timing of routine prenatal testing changed during the COVID-19 pandemic. Methods Retros…
View article: Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity
Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity Open
View article: Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy
Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy Open
View article: Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up
Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up Open
ClinicalTrials.gov Identifier: NCT01192776.
View article: Birth Hospital Length of Stay and Rehospitalization During COVID-19
Birth Hospital Length of Stay and Rehospitalization During COVID-19 Open
OBJECTIVES To determine if birth hospitalization length of stay (LOS) and infant rehospitalization changed during the coronavirus disease 2019 (COVID-19) era among healthy, term infants. METHODS Retrospective cohort study using Epic’s Cosm…
View article: Is it time to study routine car seat tolerance screening in a randomized controlled trial? An international survey of current practice and clinician equipoise
Is it time to study routine car seat tolerance screening in a randomized controlled trial? An international survey of current practice and clinician equipoise Open
View article: Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population
Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population Open
OBJECTIVE: To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
View article: Performance Evaluation of Nasal Prong Interface for CPAP Delivery on a Critical Care Ventilator: A Bench Experiment
Performance Evaluation of Nasal Prong Interface for CPAP Delivery on a Critical Care Ventilator: A Bench Experiment Open
Use of the RAM cannula with a 30% leak on a critical care ventilator delivered [Formula: see text] values lower than set CPAP. This may be clinically meaningful and should be considered when choosing a nasal interface.
View article: Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial
Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial Open
Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models.
View article: Tolerability and Efficacy of Two Doses of Aerosolized Albuterol in Ventilated Infants with BPD
Tolerability and Efficacy of Two Doses of Aerosolized Albuterol in Ventilated Infants with BPD Open
Rationale: Aerosolized albuterol is widely used, but its safety and efficacy in infants with severe bronchopulmonary dysplasia (sBPD) is not well established. Objectives: To compare the tolerability and efficacy of two dose levels of aeros…
View article: Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants
Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants Open
Background The antibiotic use rate (AUR) has emerged as a potential metric for neonatal antibiotic use, but reported center-level AURs are limited by differences in case mix. The objective of this study was to identify patient characterist…
View article: Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding
Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding Open
Objective Compare rates of hypoxaemia during transpyloric and gastric feedings in very preterm infants with severe bronchopulmonary dysplasia. Design N-of-1 multiple crossover trials with individual patient and pooled data analyses. Settin…
View article: The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach
The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach Open
Rationale: Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, and do not adequately predict childhood morbidity.Objectiv…
View article: Association between early antibiotic exposure and bronchopulmonary dysplasia or death
Association between early antibiotic exposure and bronchopulmonary dysplasia or death Open
View article: Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra‐uterine Environment for Neonatal Development (EXTEND)
Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra‐uterine Environment for Neonatal Development (EXTEND) Open
Key points Bronchopulmonary dysplasia is a disease of extreme prematurity that occurs when the immature lung is exposed to gas ventilation. We designed a novel ‘artificial womb’ system for supporting extreme premature lambs (called EXTEND)…
View article: Car Seat Tolerance Screening in the Neonatal Intensive Care Unit: Failure Rates, Risk Factors, and Adverse Outcomes
Car Seat Tolerance Screening in the Neonatal Intensive Care Unit: Failure Rates, Risk Factors, and Adverse Outcomes Open
View article: Correction: Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb
Correction: Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb Open
Nature Communications 8: Article number: 15112 (2017); Published 25 April 2017; Updated 23 May 2017 A patent based on the work reported in this Article was inadvertently omitted from the Competing interests section of this article. The Com…
View article: An extra-uterine system to physiologically support the extreme premature lamb
An extra-uterine system to physiologically support the extreme premature lamb Open
View article: Table of Contents
Table of Contents Open
View article: Venoarterial Extracorporeal Life Support for Neonatal Respiratory Failure: Indications and Impact on Mortality
Venoarterial Extracorporeal Life Support for Neonatal Respiratory Failure: Indications and Impact on Mortality Open
Venoarterial (VA) extracorporeal life support (ECLS) for neonatal respiratory failure is associated with increased mortality compared with venovenous (VV) ECLS. It is unclear whether this is a causal relationship or reflects differences in…
View article: Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia
Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia Open
View article: Continuous Positive Airway Pressure versus Mechanical Ventilation on the First Day of Life in Very Low-Birth-Weight Infants
Continuous Positive Airway Pressure versus Mechanical Ventilation on the First Day of Life in Very Low-Birth-Weight Infants Open
Objective The objective of this study was to determine differences in the incidence of bronchopulmonary dysplasia (BPD) or death in very low-birth-weight (VLBW) infants managed successfully on continuous positive airway pressure (CPAP) ver…
View article: High Flow Nasal Cannula Use Is Associated with Increased Morbidity and Length of Hospitalization in Extremely Low Birth Weight Infants
High Flow Nasal Cannula Use Is Associated with Increased Morbidity and Length of Hospitalization in Extremely Low Birth Weight Infants Open
View article: Effects of Multiple Ventilation Courses and Duration of Mechanical Ventilation on Respiratory Outcomes in Extremely Low-Birth-Weight Infants
Effects of Multiple Ventilation Courses and Duration of Mechanical Ventilation on Respiratory Outcomes in Extremely Low-Birth-Weight Infants Open
Among ELBW infants, a longer cumulative duration of mechanical ventilation largely accounts for the increased risk of chronic respiratory morbidity associated with reinitiation of mechanical ventilation. These results support attempts of e…