Kevin Eade
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View article: Erucamide regulates retinal neurovascular crosstalk
Erucamide regulates retinal neurovascular crosstalk Open
Neurovasculoglial crosstalk is critical in establishing and maintaining a functional neurovascular unit. Breakdown in the unit is central to many neurodegenerative disorders of the CNS of which the retina is a component. A growing literatu…
View article: Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2 Open
Neurotrophic factors are a family of proteins that promote the growth and survival of both developing and mature neurons. Extensive preclinical studies have demonstrated neuroprotective properties conferred by ciliary neurotrophic factor (…
View article: eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa
eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa Open
View article: eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa
eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa Open
View article: eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa
eLife Assessment: Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa Open
View article: Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels Open
View article: Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels Open
In multiple neurodegenerative diseases, including age-related macular degeneration, retinitis pigmentosa, and macular telangiectasia type 2 (MacTel), retinal pigment epithelial (RPE)-cells proliferate and migrate into the neuroretina, form…
View article: eLife Assessment: Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells
eLife Assessment: Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells Open
Oligodendrocyte lineage cells (OLCs) are lost in many CNS diseases. Here, we investigate the generation of new OLCs via ectopic expression of Sox10, Olig2 or Nkx6.2 in mouse postnatal astrocytes. Using stringent analyses including, Aldh1l1…
View article: eLife assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
eLife assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Retinitis pigmentosa (RP) is a…
View article: eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model Open
Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease worldwide, affecting 1 in 4,000 people. The disease is characterized by an initial loss of night vision followed by a loss of daylight and color vision. Many o…
View article: eLife assessment: Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation
eLife assessment: Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation Open
View article: eLife Assessment: Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation
eLife Assessment: Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation Open
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO), account for ∼25% cases of autosomal dominant R…
View article: eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model Open
Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease worldwide, affecting 1 in 4,000 people. The disease is characterized by an initial loss of night vision followed by a loss of daylight and color vision. Many o…
View article: eLife assessment: Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation
eLife assessment: Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation Open
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO), account for ∼40% cases of autosomal dominant R…
View article: eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
eLife Assessment: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model Open
Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease worldwide, affecting 1 in 4,000 people. The disease is characterized by an initial loss of night vision followed by a loss of daylight and color vision. Many o…
View article: Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity
Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity Open
The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in …
View article: Integrating human <scp>iPSC</scp> ‐derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche
Integrating human <span>iPSC</span> ‐derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche Open
In the retina, microglia are resident immune cells that are essential for development and function. Retinal microglia play a central role in mediating pathological degeneration in diseases such as glaucoma, retinitis pigmentosa, age‐relate…
View article: iPSC–derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function
iPSC–derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function Open
Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an …
View article: Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche
Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche Open
In the retina, microglia are resident immune cells that are essential for retinal development and function. Retinal microglia play a central role in mediating pathological degeneration in diseases such as glaucoma, retinitis pigmentosa, ag…
View article: Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity
Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity Open
SUMMARY 1-Deoxysphingolipids (1-dSLs) are atypical cytotoxic sphingolipids formed through the substitution of alanine for serine in de novo sphingolipid biosynthesis. Accumulation of 1-dSLs has been linked to diseases of the eye such as di…
View article: Deletion of <scp>Tgfβ</scp> signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing <scp>Igf1</scp> expression and retinal leukostasis
Deletion of <span>Tgfβ</span> signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing <span>Igf1</span> expression and retinal leukostasis Open
Retinal neovascularization (NV) is the major cause of severe visual impairment in patients with ischemic eye diseases. While it is known that retinal microglia contribute to both physiological and pathological angiogenesis, the molecular m…
View article: Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids Open
View article: Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk
Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk Open
SUMMARY Cis-regulatory elements (CREs) play a critical role in the development, maintenance, and disease-states of all human cell types. In the human retina, CREs have been implicated in a variety of inherited retinal disorders. To charact…
View article: Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease Open
View article: Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk
Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk Open
View article: Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy Open
Elevated levels of atypical deoxysphingolipids, caused by variant SPTLC1 or SPTLC2 or by low serine levels, were risk factors for macular telangiectasia type 2, as well as for peripheral neuropathy. (Funded by the Lowy Medica…
View article: Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel
Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel Open
View article: Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel
Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel Open
View article: MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity
MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity Open
View article: Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library
Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library Open