Kevin G. Burt
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View article: HMGB1 Mediates Macrophage Recruitment and Regional Intervertebral Disc Properties Following Injury
HMGB1 Mediates Macrophage Recruitment and Regional Intervertebral Disc Properties Following Injury Open
Frequently evaluated in musculoskeletal disease, damage associated molecular patterns (DAMPs) respond to tissue damage and cellular stress by facilitating an inflammatory response via macrophage activation and broad inflammatory pathway ac…
View article: CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis
CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis Open
Inflammation is a primary driver of osteoarthritis (OA), and no therapies exist to halt or delay disease progression or substantially ameliorate the chronic pain, inflammation and disability that are characteristic of disease. Soluble CD14…
View article: HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injury
HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injury Open
Objective Frequently evaluated in musculoskeletal disease, damage associated molecular patterns (DAMPs) respond to tissue damage and cellular stress by facilitating an inflammatory response via macrophage activation and broad inflammatory …
View article: Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration
Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration Open
Persistent inflammation has been associated with severe disc degeneration (DD). This study investigated the effect of prolonged nuclear factor κB (NF-κB) activation in DD. Using an inducible mouse model, we genetically targeted cells expre…
View article: The subacromial bursa modulates tendon healing after rotator cuff injury in rats
The subacromial bursa modulates tendon healing after rotator cuff injury in rats Open
Rotator cuff injuries result in more than 500,000 surgeries annually in the United States, many of which fail. These surgeries typically involve repair of the injured tendon and removal of the subacromial bursa, a synovial-like tissue that…
View article: Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury
Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury Open
Background Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) worldwide. Sexual dimorphism, or sex‐based differences, appear to exist in the severity of LBP. However, it is unknown if there are sex‐based differe…
View article: Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury
Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury Open
Developing an imaging mass cytometry method for the mouse enabled us to identify a diverse array of synovial and IFP vascular-associated myeloid cell subpopulations. These subpopulations were differentially elevated in synovial and IFP tis…
View article: Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis
Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis Open
Background Synovial pathology has been linked to osteoarthritis (OA) pain in patients. Microscopic grading systems for synovial changes in human OA have been described, but a standardized approach for murine models of OA is needed. We soug…
View article: Nuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration
Nuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration Open
Objective Low back pain (LBP) is the leading cause of global disability and is thought to be driven primarily by intervertebral disc (IVD) degeneration (DD). Persistent upregulation of catabolic enzymes and inflammatory mediators have been…
View article: The subacromial bursa is a key regulator of the rotator cuff and a new therapeutic target for improving repair
The subacromial bursa is a key regulator of the rotator cuff and a new therapeutic target for improving repair Open
Rotator cuff injuries result in over 500,000 surgeries performed annually, an alarmingly high number of which fail. These procedures typically involve repair of the injured tendon and removal of the subacromial bursa. However, recent ident…
View article: B cells in osteoarthritis: simply a sign or a target for therapy?
B cells in osteoarthritis: simply a sign or a target for therapy? Open
View article: An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis Open
Multi‐joint disease pathologies in the lumbar spine, including ligamentum flavum (LF) hypertrophy and intervertebral disc (IVD) bulging or herniation contribute to lumbar spinal stenosis (LSS), a highly prevalent condition characterized by…
View article: High mobility group box‐1 induces pro‐inflammatory signaling in human nucleus pulposus cells via toll‐like receptor 4‐dependent pathway
High mobility group box‐1 induces pro‐inflammatory signaling in human nucleus pulposus cells via toll‐like receptor 4‐dependent pathway Open
Intervertebral disc (IVD) degeneration (DD) is associated with low back pain, the leading cause of disability worldwide. Damage‐associated molecular patterns (DAMPs) that contribute to inflammation and trigger DD have not been well charact…