Explanipedia

1212 Utilization of artificial intelligence support for early lung cancer diagnosis in a lung nodule program: a retrospective cohort study Open

Nathan R. Hill, Travis Dotson, Sarah E Maus, Christina Bellinger, Annika Rings , et al. · 2024

AB0347 TREATMENT RESPONSE WITH ABATACEPT PLUS METHOTREXATE TREATMENT FOR RHEUMATOID ARTHRITIS: REAL-WORLD EVIDENCE FROM THE UK Open

E. Choy, S. Henning, M. Brazil, Kevin G. Pollock, L. Groves , et al. · 2022

Identification of undiagnosed atrial fibrillation using a machine learning risk-prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomized controlled trial in England Open

Nathan R. Hill, Lara Groves, Carissa Dickerson, Andreas Ochs, Dong Pang , et al. · 2022

Aims The aim of the PULsE-AI trial was to assess the effectiveness of a machine learning risk-prediction algorithm in conjunction with diagnostic testing for identifying undiagnosed atrial fibrillation (AF) in primary care in England. Meth…

Using machine learning to predict anticoagulation control in atrial fibrillation: A UK Clinical Practice Research Datalink study Open

Jason Gordon, Max Norman, Michael Hurst, Thomas Mason, Carissa Dickerson , et al. · 2021

Objective: To investigate the predictive performance of machine learning (ML) algorithms for estimating anticoagulation control in patients with atrial fibrillation (AF) who are treated with warfarin. Methods: This was a retrospective coho…

Application of a machine learning algorithm for detection of atrial fibrillation in secondary care Open

Kevin G. Pollock, Sara Sekelj, Ellie Johnston, Belinda Sandler, Nathan R. Hill , et al. · 2020

Impact of an influenza information pamphlet on vaccination uptake among Polish pupils in Edinburgh, Scotland and the role of social media in parental decision making Open

Klaudia Bielecki, J. Craig, Lorna Willocks, Kevin G. Pollock, Dermot Gorman · 2020

Real‐world utility of HCV core antigen as an alternative to HCV RNA testing: Implications for viral load and genotype Open

Kevin G. Pollock, Scott McDonald, Rory Gunson, Allan McLeod, April Went , et al. · 2020

Following positive serology, the gold standard confirmatory test of hepatitis C virus (HCV) infection is detection of HCV RNA by PCR. We assessed the utility of HCV core antigen testing to identify active infection among those positive for…

Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study Open

Sharon Hutchinson, Heather Valerio, Scott McDonald, Alan C. Yeung, Kevin G. Pollock , et al. · 2020

Objective Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) thr…

Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method Open

Steven Dyke, Iain Barrass, Kevin G. Pollock, Ian Hall · 2019

Legionnaires' disease, a form of pneumonia which can be fatal, is transmitted via the inhalation of water droplets containing Legionella bacteria. These droplets can be dispersed in the atmosphere several kilometers from their source. The …

Real‐world impact following initiation of interferon‐free hepatitis C regimens on liver‐related outcomes and all‐cause mortality among patients with compensated cirrhosis Open

Scott McDonald, Kevin G. Pollock, Stephen T. Barclay, David Goldberg, Andrew Bathgate , et al. · 2019

Few studies have investigated clinical outcomes among patients with cirrhosis who were treated with interferon (IFN)‐free direct‐acting antiviral (DAA). We aimed to quantify treatment impact on first decompensated cirrhosis hospital admiss…

Information sources and attitudes of Polish migrants accepting or declining vaccination in Scotland Open

Dermot Gorman, Klaudia Bielecki, Lorna Willocks, Kevin G. Pollock, J Munshaw , et al. · 2019

Background Poland has the lowest EU vaccine confidence scores. The Polish are the largest migrant group in Scotland (91,000) with a high decline rate of nasal influenza vaccination. A new Polish language information leaflet in the 2018 sch…

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis Open

Mélanie Drolet, Élodie Bénard, Norma Pérez, Marc Brisson, Hammad Ali , et al. · 2019

A Prospective Cohort Study of Human Papillomavirus-Driven Oropharyngeal Cancers: Implications for Prognosis and Immunisation Open

Katie Wakeham, Jiafeng Pan, Kevin G. Pollock, David Millan, Sarah Bell , et al. · 2019

Increased risk of HPV‐associated genital cancers in men and women as a consequence of pre‐invasive disease Open

Jiafeng Pan, Kimberley Kavanagh, Kate Cuschieri, Kevin G. Pollock, Duncan C. Gilbert , et al. · 2019

To assess the excess risk of HPV‐associated cancer (HPVaC) in two at‐risk groups—women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non‐cervical pre‐invasive anogenita…

Development of an in-house ELISA to detect anti-HPV16-L1 antibodies in serum and dried blood spots Open

Ramya Bhatia, June Stewart, Sharon Moncur, Heather Cubie, Kimberley Kavanagh , et al. · 2018

Sustained Cross-protection of the Bivalent Human Papillomavirus Vaccine Open

Kevin G. Pollock · 2018

Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study Open

Kimberley Kavanagh, Kevin G. Pollock, Kate Cuschieri, Timothy Palmer, Ross Cameron , et al. · 2017

An outbreak of mumps with genetic strain variation in a highly vaccinated student population in Scotland Open

Lorna Willocks, Daniel Guerendiain, Hannah Austin, Kirsty Morrison, Ross Cameron , et al. · 2017

SUMMARY An outbreak of mumps within a student population in Scotland was investigated to assess the effect of previous vaccination on infection and clinical presentation, and any genotypic variation. Of the 341 cases, 79% were aged 18–24. …

Overcoming barriers in HPV vaccination and screening programs Open

Alex Vorsters, Marc Arbyn, Marc Baay, Xavier Bosch, Silvia de Sanjosé , et al. · 2017

Waning Immunity Is Associated with Periodic Large Outbreaks of Mumps: A Mathematical Modeling Study of Scottish Data Open

Dalila Hamami, Ross Cameron, Kevin G. Pollock, Carron Shankland · 2017

Vaccination programs for childhood diseases, such as measles, mumps and rubella have greatly contributed to decreasing the incidence and impact of those diseases. Nonetheless, despite long vaccination programmes across the world, mumps has…

Development of a cross-cultural HPV community engagement model within Scotland Open

Elaine Carnegie, Anne Whittaker, Carol Gray Brunton, Rhona Hogg, Catriona Kennedy , et al. · 2017

Objective: To examine cultural barriers and participant solutions regarding acceptance and uptake of the human papillomavirus (HPV) vaccine from the perspective of Black African, White-Caribbean, Arab, Indian, Bangladeshi and Pakistani you…

The impact of human papillomavirus type on colposcopy performance in women offered <span>HPV</span> immunisation in a catch‐up vaccine programme: a two‐centre observational study Open

Aime Munro, Colin S. Gillespie, Seonaidh Cotton, Camille Busby‐Earle, Kimberley Kavanagh , et al. · 2017

Objective To determine whether human papillomavirus ( HPV ) immunisation has affected the prevalence of HPV genotypes and colposcopic features of cervical intraepithelial neoplasia ( CIN ) in young women referred for colposcopy. Design A t…

Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings Open

David I. Conway, Chris Robertson, Heather Gray, Linda Young, Lisa McDaid , et al. · 2016

The purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male and female patie…

HPV status and favourable outcome in vulvar squamous cancer Open

Katie Wakeham, Kimberley Kavanagh, Kate Cuschieri, David Millan, Kevin G. Pollock , et al. · 2016

It is universally accepted that high‐risk human papillomavirus (HR‐HPV) is the cause of cervical dysplasia and cancer. More recently, it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemp…

Cultural reflections on the Scottish HPV vaccination programme Open

Elaine Carnegie, Anne Whittaker, Carol Gray Brunton, Noreen Hanif, Seeromanie Harding , et al. · 2016

BackgroundThe Scottish HPV vaccination programme serves youngwomen aged 11 to 18 years and reports consistently highuptake rates, yet these figures may conceal levels of understandingand antecedents to decision-making. Evidence fromother E…

Young men with intellectual disabilities’ constructions of the human papillomavirus and vaccine Open

Elaine Carnegie, Andrea Whittaker, Carol Gray Brunton, Seeromanie Harding, Shona Hilton , et al. · 2016

Scotland is one European country offering a national schoolbasedHPV vaccination programme to at least one age-cohort of females, however it does not include young men. A substantial body of literature explores and measures attitudes of you…

Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes Open

David Mesher, Kate Soldan, Matti Lehtinen, Simon Beddows, Marc Brisson , et al. · 2016

We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, …

Impact of partial bivalent HPV vaccination on vaccine-type infection: a population-based analysis Open

Kate Cuschieri, Kimberley Kavanagh, Catherine Moore, Ramya Bhatia, J. Christopher Love , et al. · 2016

Use of HPV testing for cervical screening in vaccinated women—Insights from the SHEVa (Scottish HPV Prevalence in Vaccinated Women) study Open

Ramya Bhatia, Kimberley Kavanagh, Heather Cubie, Itziar Serrano, Holli Wennington , et al. · 2016

The management of cervical disease is changing worldwide as a result of HPV vaccination and the increasing use of HPV testing for cervical screening. However, the impact of vaccination on the performance of HPV based screening strategies i…

HPV immunisation and cervical screening—confirmation of changed performance of cytology as a screening test in immunised women: a retrospective population-based cohort study Open

Timothy Palmer, Mag McFadden, Kevin G. Pollock, Kimberley Kavanagh, Kate Cuschieri , et al. · 2016

The lower incidence of disease in vaccinated women alters the key performance indicators of cervical cytology used to monitor the quality of the screening programme. These findings have implications for screening, colposcopy referral crite…

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