Kevin Holcomb YOU? Author Swipe

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Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities Open

Hui–Hsuan Kuo, Bhavneet Bhinder, Hamza N. Gokozan, Kathryn Gorski, Pooja Chandra , et al. · 2025

We developed a tumor-matched, pan-cancer patient-derived organoid (PDO) platform comprising 220 PDOs from 190 patients across 15 cancer types to advance functional precision oncology. Our comprehensively characterized PDOs showed 93% histo…

Table S5 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Table S5 contains all the primers used in this study

Supplementary Figures from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Figure S1. (a) Effect of dietary iron levels on ovarian cancer progression. Figure S2. Flow cytometry gating strategy for the analysis of peritoneal cells from mice bearing ID8Defb29/Vegfa tumors that were treated with deferiprone as singl…

Table S4 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Table S4 describes the organoids used in this study

Table S1 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Table S1 describes all the human ascites samples analyzed

Table S2 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Table S2 contains all the information related to mass spectrometry

Table S3 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2025

Table S3 contains all statistically significant DEGs from RNAseq data

Whole Genome Analysis Identifies Homologous Recombination Deficiency in Cancers with BRCA1/2 Wild-Type and BRCA1/2 Structural Variants Open

Juan Miguel Mosquera, Majd Al Assaad, Kevin Hadi, Max F. Levine, Daniela Guevara , et al. · 2024

Purpose Homologous recombination deficiency (HRD) impacts cancer treatment strategies, particularly effective utilization of PARP inhibitors. However, the variability of different HRD assays has hampered the selection of oncology patients …

Table S1 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Table S1 describes all the human ascites samples analyzed

Data from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects of iron chelation in the tumor microenvironment are…

Table S4 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Table S4 describes the organoids used in this study

Supplementary Figures from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Figure S1. (a) Effect of dietary iron levels on ovarian cancer progression. Figure S2. Flow cytometry gating strategy for the analysis of peritoneal cells from mice bearing ID8Defb29/Vegfa tumors that were treated with deferiprone as singl…

Table S5 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Table S5 contains all the primers used in this study

Table S3 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Table S3 contains all statistically significant DEGs from RNAseq data

Table S2 from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Table S2 contains all the information related to mass spectrometry

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Camilla Salvagno, Chang-Suk Chae, Deepika Awasthi, Paolo Giovanelli , et al. · 2024

Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects of iron chelation in the tumor microenvironment are…

Non-Radiation Associated Vaginal Epithelioid Angiosarcoma: Case Report Open

Maria Athenas Ramos Escalante, Higinia R. Cárdenes, Kevin Holcomb, Annacarolina da Silva · 2024

Building knowledge using a novel web-based intervention to promote HPV vaccination in a diverse, low-income population Open

Emily Webster, Muhammad Danyal Ahsan, Amita Kulkarni, Emilio Peñate, Shanice Beaumont , et al. · 2023

Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function Open

Sung‐Min Hwang, Deepika Awasthi, Jeong Jieun, Tito A. Sandoval, Chang-Suk Chae , et al. · 2023

Mounting effective immunity against pathogens and tumors relies on the successful metabolic programming of T cells by extracellular fatty acids^1-3. During this process, fatty-acid-binding protein 5 (FABP5) imports lipids that fu…

PR001/#687 Pan-gynecologic cancer analysis of somatic homologous recombination deficiency pathogenic gene variants: more prevalent than we think? Open

Muhammad Danyal Ahsan, Emily Webster, Murtaza Qazi, Xuan Li, Sarah R. Levi , et al. · 2023

Introduction We conducted a pan-gynecologic cancer analysis of the prevalence of somatic pathogenic gene variants (PGVs) in homologous recombination deficiency (HRD) genes. Methods The American Association for Cancer Research's (AACR) Proj…

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer Open

Tito A. Sandoval, Chang-Suk Chae, Camilla Salvagno, Deepika Awasthi, Elí Terán-Cabanillas , et al. · 2023

Iron accumulation in cancer cells contributes to malignant progression and chemoresistance. While disrupting this process can influence various hallmarks of cancer, the immunomodulatory effects of chelating iron in tumors remain undefined.…

Chatbot Artificial Intelligence for Genetic Cancer Risk Assessment and Counseling: A Systematic Review and Meta-Analysis Open

Emily Webster, Muhammad Danyal Ahsan, Luiza Perez, Sarah R. Levi, Charlene Thomas , et al. · 2023

PURPOSE Most individuals with a hereditary cancer syndrome are unaware of their genetic status due to underutilization of hereditary cancer risk assessment. Chatbots, or programs that use artificial intelligence to simulate conversation, h…

Does electronic health literacy inform telemedicine acceptability among gynecologic oncology patients in an outpatient setting? (2247) Open

Corbyn Nchako, Muhammad Danyal Ahsan, Emily S. Miller, Emilio Peñate, Jessica Kim , et al. · 2023

Use of a web-based educational intervention to improve knowledge and follow-up among diverse patients with abnormal cervical cancer screening: Achieving health equity through education (2156) Open

Amita Kulkarni, Muhammad Danyal Ahsan, Taylor Larosa, Emily Webster, Xiaoyue Ma , et al. · 2023

Cascade genetic testing in racial and ethnic minorities: Are we Leaving them out? A systematic review and meta-analysis (2130) Open

Natalie Nguyen, Muhammad Danyal Ahsan, Emily Webster, Sarah R. Levi, Jenny Lin , et al. · 2023

Using a web-based tool to improve family cancer history collection: Is there a downside? (2177) Open

Muhammad Danyal Ahsan, Emily Webster, Emily Miller, Isabel Wolfe, Amita Kulkarni , et al. · 2023

#1090 The mutational landscape of uterine sarcoma: is there rationale for targeted therapies? Open

Muhammad Danyal Ahsan, Emily Webster, Murtaza Qazi, Jessica M. Weiss, Sarah R. Levi , et al. · 2023

Introduction/Background We aimed to characterize the mutational landscape of uterine sarcoma. Methodology Data were extracted from the American Association for Cancer Research's (AACR) Project Genomics Evidence Neoplasia Information Exchan…

Can we talk about sex? Universal sexual health screening for cancer survivors and previvors with hereditary breast and ovarian cancer syndromes (2188) Open

Amita Kulkarni, Corbyn Nchako, Muhammad Danyal Ahsan, Chandrawattie Bhoj, Shayan Dioun , et al. · 2023

Attitudes and beliefs regarding complementary and alternative medicine in a diverse gynecologic oncology patient population Open

Emily Miller, Shanice Beaumont, Zhen Zhou, Jesse Brewer, Charlene Thomas , et al. · 2023

Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature Open

Luiza Perez, Emily Webster, Leslie Bull, Jesse Brewer, Muhammad Danyal Ahsan , et al. · 2023

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