Kevin J. Contrera
YOU?
Author Swipe
View article: Integrating artificial intelligence-driven digital pathology and genomics to establish patient-derived organoids as new approach methodologies for drug response in head and neck cancer
Integrating artificial intelligence-driven digital pathology and genomics to establish patient-derived organoids as new approach methodologies for drug response in head and neck cancer Open
Patient-derived organoids (PDOs) emerge as advanced 3D ex vivo New Approach Methodologies (NAM) preclinical models, offering significant advantages over traditional cell lines and monolayer cultures for therapeutic development. In this stu…
View article: Survival for Head and Neck Squamous Cell Carcinoma Treated With Versus Without Neoadjuvant Systemic Therapy: A National Propensity Score–Matched Analysis
Survival for Head and Neck Squamous Cell Carcinoma Treated With Versus Without Neoadjuvant Systemic Therapy: A National Propensity Score–Matched Analysis Open
PURPOSE The survival benefit of neoadjuvant systemic therapy for head and neck squamous cell carcinoma (HNSCC) remains under investigation. This study evaluated the association of neoadjuvant systemic therapy with overall survival (OS) in …
View article: Trends in the Use of Neoadjuvant Systemic Therapy for Head and Neck Squamous Cell Carcinoma
Trends in the Use of Neoadjuvant Systemic Therapy for Head and Neck Squamous Cell Carcinoma Open
Importance A paradigm shift is currently under way for the treatment of head and neck squamous cell carcinoma (HNSCC). Recent trials have demonstrated potential effectiveness of neoadjuvant systemic therapy (NST), including chemotherapy an…
View article: Circulating tumor DNA in Non-Viral head and neck squamous cell Carcinoma: A systematic review and Meta-Analysis
Circulating tumor DNA in Non-Viral head and neck squamous cell Carcinoma: A systematic review and Meta-Analysis Open
Non-viral head and neck squamous cell carcinoma (HNSCC) has poor survival and high recurrence rates. Circulating tumor DNA (ctDNA) is a promising biomarker for understanding tumor biology, assessing treatment response, and monitoring disea…
View article: Metal 3D printing of prosthetics and implants for head and neck oncologic reconstruction
Metal 3D printing of prosthetics and implants for head and neck oncologic reconstruction Open
Indications for resection of maxillofacial and mandibular skeletal structures include extirpation of benign and malignant tumors, trauma, and congenital defects. Reconstruction of these structures often demands free tissue transfer incorpo…
View article: Head and Neck Cancer Incidence in the United States Following the Onset of <scp>COVID</scp> ‐19 Pandemic
Head and Neck Cancer Incidence in the United States Following the Onset of <span>COVID</span> ‐19 Pandemic Open
View article: Artificial Intelligence in Head and Neck Cancer: Towards Precision Medicine
Artificial Intelligence in Head and Neck Cancer: Towards Precision Medicine Open
Head and neck cancer (HNC) encompasses malignant neoplasms originating from the soft tissues of the nasal cavity, paranasal sinuses, oral cavity, pharynx, larynx, skin, and thyroid [...]
View article: Prognostic Significance of Neutrophil-Lymphocyte Ratio in Salivary Gland Neoplasms: A Systematic Review
Prognostic Significance of Neutrophil-Lymphocyte Ratio in Salivary Gland Neoplasms: A Systematic Review Open
Importance Salivary gland tumors (SGTs) are rare and heterogeneous, necessitating improved prognostic tools to optimize patient management. Objective To evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in distingui…
View article: Trends in Human Papillomavirus Testing Among Patients With Oropharyngeal Cancer
Trends in Human Papillomavirus Testing Among Patients With Oropharyngeal Cancer Open
Importance Due to the prognostic value of human papillomavirus (HPV) status, HPV testing for oropharyngeal squamous cell carcinoma (OPSCC) has been recommended since 2012. However, recent HPV testing rates and associated sociodemographic a…
View article: Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer
Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer Open
Patient-derived organoids (PDOs) are emerging as advanced 3D ex vivo novel alternative method (NAM) preclinical models, offering significant advantages over traditional cell lines and monolayer cultures for therapeutic development. In this…
View article: Drain Fluid Amylase as an Early Negative Predictor of Salivary Fistula Following Free Flap Reconstruction
Drain Fluid Amylase as an Early Negative Predictor of Salivary Fistula Following Free Flap Reconstruction Open
Objectives Salivary fistula is a known complication following head and neck free flap reconstruction involving the aerodigestive tract. We sought to examine the association between surgical drain fluid amylase and salivary fistula formatio…
View article: Emerging Proximal Liquid Biopsy Approaches for Detecting Residual Disease and Predicting Recurrence in Head and Neck Cancer: A Review and Proposal of Novel Liquid Staging
Emerging Proximal Liquid Biopsy Approaches for Detecting Residual Disease and Predicting Recurrence in Head and Neck Cancer: A Review and Proposal of Novel Liquid Staging Open
Background Head and neck squamous cell carcinoma remains challenging due to high recurrence rates and poor survival outcomes. Developing precise technologies for disease burden assessment, treatment response, and minimal residual disease (…
View article: Use of Tranexamic Acid in Head and Neck Free Flap Reconstruction
Use of Tranexamic Acid in Head and Neck Free Flap Reconstruction Open
Introduction Tranexamic acid (TXA) is commonly used in surgical settings to reduce blood loss. Due to its antifibrinolytic properties, TXA theoretically increases the risk of thrombosis. In this study, the use of TXA was assessed in patien…
View article: The Evolution of Multidisciplinary Head and Neck Cancer Treatment
The Evolution of Multidisciplinary Head and Neck Cancer Treatment Open
Objective The management of head and neck squamous cell carcinoma (HNSCC) has substantially changed over the past two centuries. This review explores the historical progression of HNSCC management focusing on the multidisciplinary treatmen…
View article: Supplementary Table S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Table S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Representativeness of Study Participants
View article: Data from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Data from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Purpose:Outcomes after primary surgery for advanced sinonasal squamous cell carcinoma (SCC) are poor. We tested whether induction chemotherapy (IC) can improve disease control or organ preservation.Patients and Methods:A phase II trial eva…
View article: Supplementary Figure S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Figure S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Imaging with Induction
View article: Supplementary Data S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Data S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Protocol
View article: Supplementary Figure S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Figure S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Trial Schema
View article: Supplementary Table S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Table S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Patient Clinical and Pathologic Characteristics
View article: Rapid and Sensitive Digital Droplet PCR Assays for Detecting HPV16 DNA in Liquid Biopsies
Rapid and Sensitive Digital Droplet PCR Assays for Detecting HPV16 DNA in Liquid Biopsies Open
The combination of cell‐free DNA (cfDNA) and digital droplet PCR (ddPCR) has significantly advanced the noninvasive screening, diagnosis, and monitoring of diseases, enabling highly sensitive and absolute quantification of target nucleic a…
View article: Oral cavity obliteration is a novel predictor of functional outcomes after glossectomy reconstruction
Oral cavity obliteration is a novel predictor of functional outcomes after glossectomy reconstruction Open
Oral volume assessment test (OVAT) is a novel measure of residual volume (obliteration) that correlates with improved speech efficiency, intelligibility, speaking in public and swallowing outcomes.
View article: Endoscope‐Assisted Transcervical Resection of Parapharyngeal Space Tumors
Endoscope‐Assisted Transcervical Resection of Parapharyngeal Space Tumors Open
Objective We describe a novel technique for endoscope‐assisted (EA) transcervical (TC) approach for resection of parapharyngeal space (PPS) tumors and compare perioperative outcomes of this approach to standard TC approaches. Study Design …
View article: 3D modeling of anterior 2/3rds glossectomy reconstruction: A volume based donor site evaluation
3D modeling of anterior 2/3rds glossectomy reconstruction: A volume based donor site evaluation Open
The DIEP flap more closely approximates the volume needed to reconstruct anterior two-thirds tongue defects for BMIs ≤ 30. The subscapular system flaps provided the best volume match for BMIs > 30 and the DIEP flap provided excess tissue b…
View article: Patterns of failure after salvage head and neck surgery
Patterns of failure after salvage head and neck surgery Open
Rates of recurrence and mortality after salvage surgery were poor but worse for patients who were Black, older, smoked, had initial multimodal therapy, or had sinonasal or oropharyngeal cancers.
View article: The role of surgery and deescalation for HPV‐related oropharyngeal cancer
The role of surgery and deescalation for HPV‐related oropharyngeal cancer Open
Recently published and ongoing trials are helping to define the role of transoral robotic surgery for oropharyngeal cancer. Evidence to date supports the use of surgery as a valuable tool in the multidisciplinary deescalation of low‐risk h…
View article: Clinical Practice Guideline: Immunotherapy for Inhalant Allergy
Clinical Practice Guideline: Immunotherapy for Inhalant Allergy Open
Objective Allergen immunotherapy (AIT) is the therapeutic exposure to an allergen or allergens selected by clinical assessment and allergy testing to decrease allergic symptoms and induce immunologic tolerance. Inhalant AIT is administered…
View article: Executive Summary of Clinical Practice Guideline on Immunotherapy for Inhalant Allergy
Executive Summary of Clinical Practice Guideline on Immunotherapy for Inhalant Allergy Open
Objective Allergen immunotherapy (AIT) is the therapeutic exposure to an allergen or allergens selected by clinical assessment and allergy testing to decrease allergic symptoms and induce immunologic tolerance. Inhalant AIT is administered…
View article: Induction Chemotherapy for Sinonasal Tumors in Patients Presenting with Brain Invasion and/or Neurological Deficits
Induction Chemotherapy for Sinonasal Tumors in Patients Presenting with Brain Invasion and/or Neurological Deficits Open
Objective The aim of this study was to investigate the safety of induction chemotherapy (IC) for patients with sinonasal malignancies with brain invasion or a neurological deficit. Methods We conducted a retrospective analysis of patients …
View article: Prevalence of pituitary hormone dysfunction following radiotherapy for sinonasal and nasopharyngeal malignancies
Prevalence of pituitary hormone dysfunction following radiotherapy for sinonasal and nasopharyngeal malignancies Open
Background There are limited studies and no surveillance protocols on pituitary dysfunction for adults who underwent anterior skull base radiation. Methods Cross‐sectional study of 50 consecutive patients with sinonasal or nasopharyngeal c…