Kevin J. Dawson
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View article: Author Correction: Clonal dynamics and somatic evolution of haematopoiesis in mouse
Author Correction: Clonal dynamics and somatic evolution of haematopoiesis in mouse Open
View article: Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis Open
The mechanisms through which mutations in splicing factor genes drive clonal hematopoiesis (CH) and myeloid malignancies, and their close association with advanced age, remain poorly understood. Here we show that telomere maintenance plays…
View article: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia Open
Mutation of some genes drives uncontrolled cell proliferation and cancer. The Philadelphia chromosome in chronic myeloid leukaemia (CML) provided the very first such genetic link to cancer 1,2 . However, little is known about the trajector…
View article: Clonal dynamics and somatic evolution of haematopoiesis in mouse
Clonal dynamics and somatic evolution of haematopoiesis in mouse Open
View article: Clonal dynamics after allogeneic haematopoietic cell transplantation
Clonal dynamics after allogeneic haematopoietic cell transplantation Open
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor 1,2 . Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes from 2,824 sing…
View article: Clonal dynamics and somatic evolution of haematopoiesis in mouse
Clonal dynamics and somatic evolution of haematopoiesis in mouse Open
Haematopoietic stem cells maintain blood production throughout life. While extensively characterised using the laboratory mouse, little is known about how the population is sustained and evolves with age. We isolated stem cells and progeni…
View article: Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction Open
Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate, progress and respond to selective pressures. We launched the ICGC–TCGA (Internation…
View article: Mitochondrial mutation, drift and selection during human development and ageing
Mitochondrial mutation, drift and selection during human development and ageing Open
Progressive dysfunction of mitochondria, organelles responsible for energy provision to cells, is a major hallmark of ageing. How the dysfunction steadily accrues over a lifetime remains unclear, given the transient nature of free radical …
View article: Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic mutations
Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic mutations Open
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those harvested from a donor, and is received by 40,000 patients worldwide each year. To quantify dynamics of long-term stem…
View article: Author Correction: The evolutionary history of 2,658 cancers
Author Correction: The evolutionary history of 2,658 cancers Open
View article: Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig Open
In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortiumwere listed in the Supplementary Information; however, these members shouldhave been included in themainpaper.The originalArt…
View article: Author Correction: Inferring structural variant cancer cell fraction
Author Correction: Inferring structural variant cancer cell fraction Open
View article: Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia Open
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized th…
View article: Clonal dynamics of haematopoiesis across the human lifespan
Clonal dynamics of haematopoiesis across the human lifespan Open
Age-related change in human haematopoiesis causes reduced regenerative capacity 1 , cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer 4–6 , but the reason for such abrupt functional decline after 70 years of age remain…
View article: Life histories of myeloproliferative neoplasms inferred from phylogenies.
Life histories of myeloproliferative neoplasms inferred from phylogenies. Open
View article: Clonal dynamics of haematopoiesis across the human lifespan
Clonal dynamics of haematopoiesis across the human lifespan Open
Age-related change in human haematopoiesis causes reduced regenerative capacity 1 , cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer. The cellular alterations that underpin the abruptness of this functional decline af…
View article: Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes Open
View article: The mutational landscape of human somatic and germline cells
The mutational landscape of human somatic and germline cells Open
During the course of a lifetime normal human cells accumulate mutations. Here, using multiple samples from the same individuals we compared the mutational landscape in 29 anatomical structures from soma and the germline. Two ubiquitous mut…
View article: Phylogenetic reconstruction of adult blood cancer reveals early origins and lifelong evolution.
Phylogenetic reconstruction of adult blood cancer reveals early origins and lifelong evolution. Open
Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 448,553 somatic mutations from whole-genome seque…
View article: Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution
Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution Open
Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 448,553 somatic mutations from whole-genome seque…
View article: Author Correction: The evolutionary history of lethal metastatic prostate cancer
Author Correction: The evolutionary history of lethal metastatic prostate cancer Open
View article: Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations
Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations Open
To date, ontogeny of the human haematopoietic system during foetal development has been characterized mainly through careful microscopic observations. Here we used whole-genome sequencing (WGS) of 511 single-cell derived haematopoietic col…
View article: The evolutionary history of 2,658 cancers
The evolutionary history of 2,658 cancers Open
View article: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig Open
The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation proces…
View article: Timing the initiation of multiple myeloma
Timing the initiation of multiple myeloma Open
View article: Genomic landscape and chronological reconstruction of driver events in multiple myeloma
Genomic landscape and chronological reconstruction of driver events in multiple myeloma Open
The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients to…
View article: PS1147 SPATIAL HETEROGENEITY IN CHRONIC LYMPHOCYTIC LEUKAEMIA ANALYSED BY WHOLE‐GENOME/EXOME SEQUENCING AT DIAGNOSIS
PS1147 SPATIAL HETEROGENEITY IN CHRONIC LYMPHOCYTIC LEUKAEMIA ANALYSED BY WHOLE‐GENOME/EXOME SEQUENCING AT DIAGNOSIS Open
Background: Chronic lymphocytic leukaemia (CLL) is characterised by the accumulation of neoplastic B cells in peripheral blood (PB), lymph nodes (LN) and bone marrow. CLL cells recirculate from PB to LN where the crosstalk with the microen…
View article: Timing the Initiation of Multiple Myeloma
Timing the Initiation of Multiple Myeloma Open
View article: The mutational landscape of normal human endometrial epithelium
The mutational landscape of normal human endometrial epithelium Open
All normal somatic cells are thought to acquire mutations. However, characterisation of the patterns and consequences of somatic mutation in normal tissues is limited. Uterine endometrium is a dynamic tissue that undergoes cyclical sheddin…
View article: Population dynamics of normal human blood inferred from somatic mutations
Population dynamics of normal human blood inferred from somatic mutations Open