Kevin J. Tracey
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View article: Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior
Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior Open
Background High Mobility Group Box 1 (HMGB1) is a nuclear protein that upon extracellular release acts as an alarmin to initiate and amplify inflammation. HMGB1 release from nociceptors contributes to both inflammation and pain; however, t…
View article: Engaging Brain Anti-inflammatory Circuits to Improve the Viability of Transplanted Organs
Engaging Brain Anti-inflammatory Circuits to Improve the Viability of Transplanted Organs Open
Solid organ transplantation is a life-saving intervention for tens of thousands of patients each year in the United States. A major underlying pathophysiologic process limiting the success of transplantation is inflammation. Since the firs…
View article: The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice
The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice Open
View article: Repurposing a Detrimental Antibody Epitope as Targeted Therapeutics for Sepsis and Rheumatoid Arthritis.
Repurposing a Detrimental Antibody Epitope as Targeted Therapeutics for Sepsis and Rheumatoid Arthritis. Open
View article: Correction: HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
Correction: HMGB1 release and redox regulates autophagy and apoptosis in cancer cells Open
View article: Pro-dermcidin and derivatives as potential therapeutics for lethal experimental sepsis
Pro-dermcidin and derivatives as potential therapeutics for lethal experimental sepsis Open
A 110-amino acid precursor of dermcidin (pre-dermcidin, pre-DCD) with a 19-residue N-terminal leader signal sequence can be secreted by human eccrine sweat glands as a leader-less pro-domain-containing peptide (pro-DCD), which is enzymatic…
View article: The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice
The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice Open
Acute respiratory distress syndrome (ARDS) is a life-threatening form of acute lung injury (ALI), which is a common cause of respiratory failure and high mortality in critically ill patients. Long-term mortality and brain dysfunction have …
View article: Neural representation of cytokines by vagal sensory neurons
Neural representation of cytokines by vagal sensory neurons Open
View article: Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators reveal a pro-inflammatory state in overweight women
Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators reveal a pro-inflammatory state in overweight women Open
These results reveal the presence of a pro-inflammatory state in overweight women and are of interest for further studies with the goal for improved understanding of cardiovascular health risks in women.
View article: Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article
Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article Open
Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituita…
View article: Cytokine-responsive neurons in the bed nucleus of the stria terminalis activate acute stress response
Cytokine-responsive neurons in the bed nucleus of the stria terminalis activate acute stress response Open
View article: Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury
Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury Open
Background Acute liver injury (ALI) that progresses into acute liver failure (ALF) is a life-threatening condition with an increasing incidence and associated costs. Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosing is among the lead…
View article: Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks Open
Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscienc…
View article: Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis
Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis Open
Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) disorder that is associated with functional impairment and accruing disability. There are multiple U.S. Food and Drug Administration (FDA)-approved drugs that effectiv…
View article: TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens
TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens Open
View article: Nerve stimulation for treatment of diseases and disorders
Nerve stimulation for treatment of diseases and disorders Open
Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or…
View article: Next Directions in the Neuroscience of Cancers Arising outside the CNS
Next Directions in the Neuroscience of Cancers Arising outside the CNS Open
Summary: The field of cancer neuroscience has begun to define the contributions of nerves to cancer initiation and progression; here, we highlight the future directions of basic and translational cancer neuroscience for malignancies arisin…
View article: Correction: Galantamine ameliorates experimental pancreatitis
Correction: Galantamine ameliorates experimental pancreatitis Open
View article: Therapeutic potential of procathepsin L-inhibiting and progesterone-entrapping dimethyl-β-cyclodextrin nanoparticles in treating experimental sepsis
Therapeutic potential of procathepsin L-inhibiting and progesterone-entrapping dimethyl-β-cyclodextrin nanoparticles in treating experimental sepsis Open
The pathogenic mechanisms of bacterial infections and resultant sepsis are partly attributed to dysregulated inflammatory responses sustained by some late-acting mediators including the procathepsin-L (pCTS-L). It was entirely unknown whet…
View article: Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation
Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation Open
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the p…
View article: Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship?
Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship? Open
Autonomic dysfunction is a clinical hallmark of infection caused by SARS‐CoV‐2, but the underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important, well‐characterized mechanism for the reflexive suppression of c…
View article: Circulating extracellular choline acetyltransferase regulates inflammation
Circulating extracellular choline acetyltransferase regulates inflammation Open
Background Choline acetyltransferase (ChAT) is required for the biosynthesis of acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti‐inflammatory pathway of the vagus nerve inflammatory reflex. Ab…
View article: Galantamine ameliorates experimental pancreatitis
Galantamine ameliorates experimental pancreatitis Open
View article: Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial
Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial Open
Background Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (ta-VNS) in patients …
View article: The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies
The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies Open
View article: Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia
Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia Open
Chronic low-grade inflammation has been recognized as an underlying event linking obesity to cardiovascular disease (CVD). However, inflammatory alterations in individuals who are overweight remain understudied. To provide insight, we dete…
View article: Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn’s Disease Patients: A Prospective Open-label Study
Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn’s Disease Patients: A Prospective Open-label Study Open
Background and Aims Crohn’s disease [CD] is a debilitating, inflammatory condition affecting the gastrointestinal tract. There is no cure and sustained clinical and endoscopic remission is achieved by fewer than half of patients with curre…
View article: Transcutaneous Auricular Vagus Nerve Stimulation Attenuates Inflammatory Bowel Disease in Children: A Proof-of-Concept Clinical Trial
Transcutaneous Auricular Vagus Nerve Stimulation Attenuates Inflammatory Bowel Disease in Children: A Proof-of-Concept Clinical Trial Open
Background Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (ta-VNS) in patients …
View article: Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice
Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice Open
View article: Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia
Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia Open
Chronic low-grade inflammation has been recognized as an underlying event linking obesity to cardiovascular disease (CVD). However, inflammatory alterations in individuals who are overweight remain understudied. To provide insight, we dete…