Kevin Katz
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View article: Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: A Retrospective Genomic Analysis
Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: A Retrospective Genomic Analysis Open
Carbapenemase-producing Enterobacter (CP-Ent) are the third most prevalent species of CP-Enterobacteriaceae worldwide and exhibit greater strain diversity than other CP-species. This study aimed to describe the genomic epidem…
View article: Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant <i>Pseudomonas aeruginosa</i>
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant <i>Pseudomonas aeruginosa</i> Open
Background Ceftazidime-avibactam (CZA), ceftolozane-tazobactam (CT), and imipenem-relebactam (IMR) are newer β-lactam/β-lactamase inhibitor (BL/BLI) combinations used for treatment of multidrug resistant (MDR) Pseudomonas aeruginosa, altho…
View article: Preparedness for <i>Candida auris</i> in Canadian Nosocomial Infection Surveillance Program (CNISP) hospitals, 2024
Preparedness for <i>Candida auris</i> in Canadian Nosocomial Infection Surveillance Program (CNISP) hospitals, 2024 Open
Objective: To assess preparedness for Candida auris in Canadian hospitals. Design: Cross-sectional survey. Setting: Canadian Nosocomial Infection Surveillance Program (CNISP) hospitals. Methods: In June 2024, surveys were e-mailed to the i…
View article: Correction: Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study
Correction: Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study Open
View article: An interrupted time-series analysis assessing the association of the COVID-19 pandemic on healthcare-associated infections and antimicrobial-resistant organisms in Canadian acute care hospitals, 2018–2022
An interrupted time-series analysis assessing the association of the COVID-19 pandemic on healthcare-associated infections and antimicrobial-resistant organisms in Canadian acute care hospitals, 2018–2022 Open
View article: Invasive Group A Streptococcal Infection in Children, 1992-2023
Invasive Group A Streptococcal Infection in Children, 1992-2023 Open
Importance The resurgence of invasive group A streptococcal (iGAS) infections and progress in GAS vaccine development emphasize the importance of understanding current trends in the epidemiology of iGAS. Objective To describe the epidemiol…
View article: Comparison of pharyngeal and invasive isolates of <i>Streptococcus pyogenes</i> by whole-genome sequencing in Toronto, Canada
Comparison of pharyngeal and invasive isolates of <i>Streptococcus pyogenes</i> by whole-genome sequencing in Toronto, Canada Open
Invasive Group A streptococcal (iGAS) infections are rising in Canada and wordwide. The 2022–2023 Ontario iGAS season was among the highest recorded, a trend continuing in 2023–2024. We sequenced 38 invasive (blood) and 117 non-invasive (p…
View article: Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012–2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network
Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012–2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network Open
Background Oseltamivir is recommended for the treatment of adults hospitalized with influenza, but adherence is often suboptimal. This may be due to doubts about the reliability of the evidence supporting its benefits, particularly when in…
View article: 100. Genomic epidemiology of carbapenemase-producing <i>Enterobacter</i> species in Toronto, Canada, 2007-2021
100. Genomic epidemiology of carbapenemase-producing <i>Enterobacter</i> species in Toronto, Canada, 2007-2021 Open
Background Identification of transmission networks of carbapenemase-producing organisms (CPO) is critical to identifying their reservoirs and limiting their spread. This study aimed to use whole-genome sequencing to identify genomic relati…
View article: P-40. Impact of case and control selection on influenza vaccine effectiveness (VE) among adults aged 40 years and older hospitalized with acute respiratory illness (ARI) during 2022-2023 using a test negative design (TND): secondary analysis of the North America multi-specimen study
P-40. Impact of case and control selection on influenza vaccine effectiveness (VE) among adults aged 40 years and older hospitalized with acute respiratory illness (ARI) during 2022-2023 using a test negative design (TND): secondary analysis of the North America multi-specimen study Open
Background Case and control definitions may impact VE estimates in observational studies. Using a TND design, we evaluated how influenza vaccine effectiveness against ARI hospitalizations changed when 1) influenza cases were detected throu…
View article: P-225. Effect of isolating <i>Clostridioides difficile</i> asymptomatic carriers on the incidence of healthcare-associated <i>C. difficile</i> infections: a systematic review and meta-analysis
P-225. Effect of isolating <i>Clostridioides difficile</i> asymptomatic carriers on the incidence of healthcare-associated <i>C. difficile</i> infections: a systematic review and meta-analysis Open
Background Asymptomatic carriers are a potential source of healthcare-associated Clostridioides difficile infection (HA-CDI). Our objective was to investigate the impact of interventions to detect and isolate asymptomatic carriers during t…
View article: Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study
Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study Open
Viral genomic features have limited utility in predicting hospitalization across SARS-CoV-2 diversity. Combining clinical and viral genomic datasets provides perspective on patient specific and virus-related factors that impact COVID-19 di…
View article: Canadian health care providers' and education workers' hesitance to receive original and bivalent COVID-19 vaccines
Canadian health care providers' and education workers' hesitance to receive original and bivalent COVID-19 vaccines Open
Education workers were somewhat more likely than HCP to report being hesitant to receive COVID-19 vaccines but reasons for hesitancy were similar. Hesitancy was associated with non-receipt of previous vaccines (i.e., previous behaviour), l…
View article: Molecular and Epidemiological Characterization of Pediatric and Adult C. difficile Infection in Canadian Hospitals, 2015-2022
Molecular and Epidemiological Characterization of Pediatric and Adult C. difficile Infection in Canadian Hospitals, 2015-2022 Open
Background: The molecular and epidemiological landscape of C. difficile infection (CDI) has evolved markedly in the last decade; however, limited information is available contrasting differences between adult and pediatric populations. We …
View article: Plasmid genomic epidemiology of carbapenem-hydrolysing class D β-lactamase (CDHL)-producing Enterobacterales in Canada, 2010−2021
Plasmid genomic epidemiology of carbapenem-hydrolysing class D β-lactamase (CDHL)-producing Enterobacterales in Canada, 2010−2021 Open
Carbapenems are last-resort antibiotics for treatment of infections caused by multidrug-resistant Enterobacterales , but carbapenem resistance is a rising global threat due to the acquisition of carbapenemase genes. Oxacillinase-48 ( bla O…
View article: Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19 Open
Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals a…
View article: Utility of hybrid whole genome sequencing in assessing potential nosocomial VIM transmission
Utility of hybrid whole genome sequencing in assessing potential nosocomial VIM transmission Open
(Narrative) Hybrid whole genome sequencing was used to investigate if nosocomial Verona integron-encoded metallo-β-lactamase (VIM) carbapenemase transmission occurred between two patients without epidemiological links or common pathogens. …
View article: 2468. The Genomic Epidemiology of Carbapenemase-Producing Enterobacterales (CPE) in Ontario, Canada, 2016
2468. The Genomic Epidemiology of Carbapenemase-Producing Enterobacterales (CPE) in Ontario, Canada, 2016 Open
Background Carbapenemase-producing Enterobacterales (CPE) are among the most urgent of antimicrobial resistance threats. In south-central Ontario, Canada, over one-third of CPE cases are associated with local healthcare and the incidence o…
View article: Plasmid genomic epidemiology of <i>bla</i> <sub>KPC</sub> carbapenemase-producing <i>Enterobacterales</i> in Canada, 2010–2021
Plasmid genomic epidemiology of <i>bla</i> <sub>KPC</sub> carbapenemase-producing <i>Enterobacterales</i> in Canada, 2010–2021 Open
Carbapenems are considered last-resort antibiotics for the treatment of infections caused by multidrug-resistant Enterobacterales , but carbapenem resistance due to acquisition of carbapenemase genes is a growing threat that has been repor…
View article: Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN)
Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) Open
Adjusting for frailty, aTIV showed statistically significantly better protection than naTIV against influenza-associated hospitalizations in older adults. In future studies, it is important to consider frailty as a significant confounder o…
View article: Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada
Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada Open
Background Respiratory syncytial virus (RSV) contributes significantly to morbidity in children, placing substantial burdens on health systems, thus RSV vaccine development and program implementation are a public health priority. More data…
View article: Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness Open
Background Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RS…
View article: Impact of COVID-19 on healthcare-associated infections in Canadian acute-care hospitals: Interrupted time series (2018–2021)
Impact of COVID-19 on healthcare-associated infections in Canadian acute-care hospitals: Interrupted time series (2018–2021) Open
Background: Data regarding the effects of the SARS-COV-2 (COVID-19) pandemic on healthcare-associated infections (HAIs) in Canadian acute-care hospitals are limited. We examined the impact of the COVID-19 pandemic on HAIs and antimicrobial…
View article: Epidemiology of central-line–associated bloodstream infection mortality in Canadian NICUs before and after 2017
Epidemiology of central-line–associated bloodstream infection mortality in Canadian NICUs before and after 2017 Open
Background: The Canadian Nosocomial Infection Surveillance Program (CNISP) observed increased mortality among neonatal intensive care unit (NICU) patients with central-line–associated bloodstream infection (CLABSI) starting in 2017. In thi…
View article: Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018
Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018 Open
View article: Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults
Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults Open
Background Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. Me…
View article: 89. On-going impact of the SARS-CoV-2 pandemic on the evolution of carbapenemase-producing <i>Enterobacterales</i> in Ontario, Canada
89. On-going impact of the SARS-CoV-2 pandemic on the evolution of carbapenemase-producing <i>Enterobacterales</i> in Ontario, Canada Open
Background The spread of carbapenemase-producing Enterobacterales (CPE) is global threat. Numerous outbreaks of CPE have been reported during the COVID-19 pandemic. We describe the impact of of the SARS-CoV-2 pandemic on the emergence of C…
View article: Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses
Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses Open
View article: Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19
Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19 Open
BackgroundWe report characteristics and outcomes of adults admitted to Canadian Immunization Research Network (CIRN) Ser-ious Outcomes Surveillance (SOS) Network hospitals with COVID-19 in 2020. MethodsPatients with laboratory-confirmed CO…
View article: Surface and Air Contamination With Severe Acute Respiratory Syndrome Coronavirus 2 From Hospitalized Coronavirus Disease 2019 Patients in Toronto, Canada, March–May 2020
Surface and Air Contamination With Severe Acute Respiratory Syndrome Coronavirus 2 From Hospitalized Coronavirus Disease 2019 Patients in Toronto, Canada, March–May 2020 Open
Background We determined the burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in air and on surfaces in rooms of patients hospitalized with coronavirus disease 2019 (COVID-19) and investigated patient characteristics …