Kevin Kinch
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View article: P14.08.B COMPARING GD AND MN MRI CONTRAST AGENTS IN PRECLINICAL GLIOBLASTOMA FOR IMAGING BIOMARKER DISCOVERY: TISSUE VALIDATION OF IMAGING PARAMETERS USING AN INNOVATIVE SPATIAL PHENOMIC APPROACH
P14.08.B COMPARING GD AND MN MRI CONTRAST AGENTS IN PRECLINICAL GLIOBLASTOMA FOR IMAGING BIOMARKER DISCOVERY: TISSUE VALIDATION OF IMAGING PARAMETERS USING AN INNOVATIVE SPATIAL PHENOMIC APPROACH Open
BACKGROUND Glioblastoma (GBM) management relies on gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance imaging (MRI). Manganese chelates might provide alternative paramagnetic enhancement which is safer (Mn is an essential n…
View article: Primary orbital sarcoma in adults: a case series with emphasis on post-irradiation sarcoma
Primary orbital sarcoma in adults: a case series with emphasis on post-irradiation sarcoma Open
To describe a series of eight adult patients with primary orbital sarcoma and to review the existing literature on orbital sarcoma and post-irradiation sarcoma. Report of eight cases and literature review. We report eight cases of primary …
View article: Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics Open
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. We investigated the the…
View article: Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics
Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics Open
IDH wild-type glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. Tackling …
View article: Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players
Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players Open
Chronic traumatic encephalopathy (CTE) is reported at high prevalence in selected autopsy case series of former contact sports athletes. Nevertheless, the contribution of CTE pathology to clinical presentation and its interaction with co-m…
View article: Burkitt’s neurolymphomatosis of the trigeminal nerve
Burkitt’s neurolymphomatosis of the trigeminal nerve Open
A 48-year-old woman presented with 8 months of right-sided burning facial pain and 4 weeks of unsteadiness. She had reduced right facial sensation and corneal reflex. She had no pyramidal or cerebellar signs. Examination of the other crani…
View article: One hundred years (and counting) of blast-associated traumatic brain injury
One hundred years (and counting) of blast-associated traumatic brain injury Open
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks. Despite being a recognised feature of comba…