Kevin Lamote
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View article: Differentiating Benign and Malignant Solitary Pulmonary Nodules Through Exhaled Breath Analysis
Differentiating Benign and Malignant Solitary Pulmonary Nodules Through Exhaled Breath Analysis Open
Lung cancer remains the leading cause of cancer-related deaths worldwide, with early detection significantly improving survival. Lung nodules are a common finding, both as incidental solitary pulmonary nodules (SPNs) and in lung cancer scr…
View article: P2.21-07 A Novel Proteomic Technique Uncovers New Diagnostic Biomarkers for Malignant Pleural Mesothelioma
P2.21-07 A Novel Proteomic Technique Uncovers New Diagnostic Biomarkers for Malignant Pleural Mesothelioma Open
View article: MA17.03 Determining the Clinical Utility of a Breath Test to Screen Asbestos-Exposed Persons for Pleural Mesothelioma
MA17.03 Determining the Clinical Utility of a Breath Test to Screen Asbestos-Exposed Persons for Pleural Mesothelioma Open
View article: Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy
Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy Open
In this study, we aimed to study the expression of SARS-CoV-2-related surface proteins in non-small-cell lung cancer (NSCLC) cells and identify clinicopathological characteristics that are related to increased membranous (m)ACE2 protein ex…
View article: Volatile organic compound profiling as a potential biomarker in irritable bowel syndrome: A feasibility study
Volatile organic compound profiling as a potential biomarker in irritable bowel syndrome: A feasibility study Open
Background Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which no diagnostic tools are currently available. Patients are diagnosed using the Rome IV criteria and subtyped into a diarrhea, constipation, or mixed …
View article: External Validation of a Breath-Based Prediction Model for Malignant Pleural Mesothelioma
External Validation of a Breath-Based Prediction Model for Malignant Pleural Mesothelioma Open
During the past decade, volatile organic compounds (VOCs) in exhaled breath have emerged as promising biomarkers for malignant pleural mesothelioma (MPM). However, as these biomarkers lack external validation, no breath test for MPM has be…
View article: Headspace Volatile Organic Compound Profiling of Pleural Mesothelioma and Lung Cancer Cell Lines as Translational Bridge for Breath Research
Headspace Volatile Organic Compound Profiling of Pleural Mesothelioma and Lung Cancer Cell Lines as Translational Bridge for Breath Research Open
Introduction Malignant pleural mesothelioma (MPM) is a lethal cancer for which early-stage diagnosis remains a major challenge. Volatile organic compounds (VOCs) in breath proved to be potential biomarkers for MPM diagnosis, but translatio…
View article: Expression of SARS-CoV-2 Related Surface Proteins in Non-Small Cell Lung Cancer Patients and the Influence of Standard of Care Therapy
Expression of SARS-CoV-2 Related Surface Proteins in Non-Small Cell Lung Cancer Patients and the Influence of Standard of Care Therapy Open
View article: Lung cancer screening by volume computed tomography: thriving to high performance
Lung cancer screening by volume computed tomography: thriving to high performance Open
Low-dose volume CT screening for lung cancer leads to a significant decrease in lung-cancer-related mortality. However, optimisation of the post-screening protocol will be crucial for optimal healthcare. https://bit.ly/2ZkJPpH.
View article: Clinical utility of diagnostic biomarkers in malignant pleural mesothelioma: a systematic review and meta-analysis
Clinical utility of diagnostic biomarkers in malignant pleural mesothelioma: a systematic review and meta-analysis Open
Malignant pleural mesothelioma (MPM) is characterised by late-stage diagnosis and poor prognosis. Currently, no screening tool is advocated and diagnosis is based on invasive techniques, which are not well tolerated. Non-invasive diagnosti…
View article: A dynamic mucin mRNA signature associates with COVID-19 disease presentation and severity
A dynamic mucin mRNA signature associates with COVID-19 disease presentation and severity Open
BACKGROUNDSARS-CoV-2 infection induces mucin overexpression, further promoting disease. Given that mucins are critical components of innate immunity, unraveling their expression profiles that dictate the course of disease could greatly enh…
View article: The Smell of Lung Transplantation
The Smell of Lung Transplantation Open
View article: Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report.
Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report. Open
Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological symptoms such as…
View article: The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?
The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers? Open
View article: A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms
A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms Open
Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of bioma…
View article: Volatomics in inflammatory bowel disease and irritable bowel syndrome
Volatomics in inflammatory bowel disease and irritable bowel syndrome Open
Volatile organic compounds (VOCs) are produced by the human metabolism, inflammation and gut microbiota and form the basis of innovative volatomics research. VOCs detected through breath and faecal analysis hence serve as attractive, non-i…
View article: Management of incidental nodules in lung cancer screening: ready for prime-time?
Management of incidental nodules in lung cancer screening: ready for prime-time? Open
Current clinical management of lung nodule patients is inefficient and therefore causes patient misclassification, which increases healthcare expenses. A precise and robust lung nodule classifier could minimise healthcare costs and disc…
View article: The electronic nose: emerging biomarkers in lung cancer diagnostics
The electronic nose: emerging biomarkers in lung cancer diagnostics Open
Lung cancer is very common and the most common cause of cancer death worldwide. Despite recent progress in the systemic treatment of lung cancer (checkpoint inhibitors and tyrosine kinase inhibitors), each year, >1.5 million people die due…
View article: Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review
Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review Open
Malignant pleural mesothelioma (MPM) is a tumour related to a historical exposure to asbestos fibres. Currently, the definite diagnosis is made only by the histological examination of a biopsy obtained through an invasive thoracoscopy. How…
View article: Exhaled breath to screen for malignant pleural mesothelioma: a validation study
Exhaled breath to screen for malignant pleural mesothelioma: a validation study Open
Malignant pleural mesothelioma (MPM) is predominantly caused by asbestos exposure and has a poor prognosis. Breath contains volatile organic compounds (VOCs) and can be explored as an early detection tool. Previously, we used multicapillar…
View article: Breath analysis by gas chromatography-mass spectrometry and electronic nose to screen for pleural mesothelioma: a cross-sectional case-control study
Breath analysis by gas chromatography-mass spectrometry and electronic nose to screen for pleural mesothelioma: a cross-sectional case-control study Open
This study shows accurate discrimination of patients with MPM from asymptomatic asbestos-exposed persons at risk by GC-MS and eNose analysis of exhaled VOCs and provides proof-of-principle of breath analysis for MPM screening.
View article: Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?
Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot? Open
Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing ea…
View article: OA22.05 Breath Analysis by Gas Chromatography-Mass Spectrometry Can Be Used to Screen for Pleural Mesothelioma
OA22.05 Breath Analysis by Gas Chromatography-Mass Spectrometry Can Be Used to Screen for Pleural Mesothelioma Open
View article: Volatile organic compounds and malignant pleural mesothelioma : simply breathtaking?
Volatile organic compounds and malignant pleural mesothelioma : simply breathtaking? Open