Kamalinder K. Singh
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View article: Gender and Ethnic Differences in Stress and Lifestyle Factors Post COVID-19 Lockdown Among Medical Students
Gender and Ethnic Differences in Stress and Lifestyle Factors Post COVID-19 Lockdown Among Medical Students Open
Introduction: Lifestyle choices can significantly impact students' stress levels, especially during the COVID-19 lockdowns. It is not known whether the management of lifestyle behaviours and stress factors post COVID-19 lockdown differs be…
View article: OPTIMISATION OF PROCESS PARAMETERS FOR JOINING AISI 409 STAINLESS STEEL AND MILD STEEL BY USING MIG WELDING
OPTIMISATION OF PROCESS PARAMETERS FOR JOINING AISI 409 STAINLESS STEEL AND MILD STEEL BY USING MIG WELDING Open
Considering various aspects like performance parameters, cost effectiveness, saving energy, environmental concern it has been observed that joining of metals, which are dissimilar in nature, has a versatile use in the field of Electronics,…
View article: Receptor-Assisted Nanotherapeutics for Overcoming the Blood–Brain Barrier
Receptor-Assisted Nanotherapeutics for Overcoming the Blood–Brain Barrier Open
Blood–brain barrier (BBB) is a distinguishing checkpoint that segregates peripheral organs from neural compartment. It protects the central nervous system from harmful ambush of antigens and pathogens. Owing to such explicit selectivity, t…
View article: Moxifloxacin loaded microspheres-composed gel for controlled release and enhanced penetration in ocular tissues: In vitro, ex vivo and in vivo proof of concept
Moxifloxacin loaded microspheres-composed gel for controlled release and enhanced penetration in ocular tissues: In vitro, ex vivo and in vivo proof of concept Open
Microspheres-enriched ocular gels are proposed in this work for the loading of a model quinolone antibiotic of broad-spectrum - moxifloxacin hydrochloride (MXF) - as an approach to achieve a controlled release profile and enhance drug's bi…
View article: Overcoming biological barriers BBB/BBTB by designing PUFA functionalised lipid-based nanocarriers for glioblastoma targeted therapy
Overcoming biological barriers BBB/BBTB by designing PUFA functionalised lipid-based nanocarriers for glioblastoma targeted therapy Open
A major obstacle for chemotherapeutics in Glioblastoma (GB) is to reach the tumour cells due to the presence of the blood-brain barrier (BBB) and chemoresistance of anticancer drugs. The present study reports two polyunsaturated fatty acid…
View article: Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis Open
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the …
View article: In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa
In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa Open
Malaria remains a life-threatening health problem and is responsible for the high rates of mortality and morbidity in the tropical and subtropical regions of the world. The increasing threat of drug resistance to available artemisinin-base…
View article: Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds
Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds Open
Biofilms are sessile communities of microorganisms, mainly bacteria, that grow on biotic and abiotic surfaces. These microorganisms are embedded within an extracellular polymeric substance that provides enhanced protection from antimicrobi…
View article: Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles
Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles Open
The described work entails the development of a simple, sensitive, green, and robust high-performance liquid chromatographic (HPLC) method for simultaneous estimation of temozolomide (TMZ) and γ-linolenic acid (GLA). The chemometric factor…
View article: Aerosolizable Lipid-Nanovesicles Encapsulating Voriconazole Effectively Permeate Pulmonary Barriers and Target Lung Cells
Aerosolizable Lipid-Nanovesicles Encapsulating Voriconazole Effectively Permeate Pulmonary Barriers and Target Lung Cells Open
The entire world has recently been witnessing an unprecedented upsurge in microbial lung infections. The major challenge encountered in treating the same is to ensure the optimum drug availability at the infected site. Aerosolization of an…
View article: Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model
Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model Open
Treatment of atopic dermatitis (AD) is challenging due to its complex pathophysiology. Tetrahydrocurcumin (THC) a polyphenolic, colorless compound that is more polar than curcumin. It possesses superior anti-inflammatory properties and has…
View article: Nanostructured Lipid Carriers Deliver Resveratrol, Restoring Attenuated Dilation in Small Coronary Arteries, via the AMPK Pathway
Nanostructured Lipid Carriers Deliver Resveratrol, Restoring Attenuated Dilation in Small Coronary Arteries, via the AMPK Pathway Open
Nanostructured lipid carriers (NLCs) are an emerging drug delivery platform for improved drug stability and the bioavailability of antihypertensive drugs and vasoprotective nutraceutical compounds, such as resveratrol (RV). The objective o…
View article: The Cytotoxic effect of an Ethanol extract of Momordica Charantia, Kuguacin-J and Cisplatin on healthy MCF-10A and MCF-7 and MDAMB-231 breast cancer cell lines employing In Vitro assays
The Cytotoxic effect of an Ethanol extract of Momordica Charantia, Kuguacin-J and Cisplatin on healthy MCF-10A and MCF-7 and MDAMB-231 breast cancer cell lines employing In Vitro assays Open
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer ef…
View article: The Cytotoxic Effect of Ethanol Extract of Momordica Charantia, Kuguacin-J and Cisplatin on Healthy MCF-10A and MCF-7 and MDAMB-231 Breast Cancer Cell Lines in Vitro
The Cytotoxic Effect of Ethanol Extract of Momordica Charantia, Kuguacin-J and Cisplatin on Healthy MCF-10A and MCF-7 and MDAMB-231 Breast Cancer Cell Lines in Vitro Open
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer ef…
View article: Epidemiological study of breast cancer patients and their association with ABO blood group
Epidemiological study of breast cancer patients and their association with ABO blood group Open
OBJECTIVE: ABO Blood groups play an important biological role in the immunological system. Studies have reported a strong relationship between ABO and Rhesus (Rh) blood types with various cancers; however, results are contrasting. This stu…
View article: The Gazette of Medical Sciences
The Gazette of Medical Sciences Open
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer ef…
View article: In vitro anti-HIV activity of some Indian medicinal plant extracts
In vitro anti-HIV activity of some Indian medicinal plant extracts Open
Background Human Immunodeficiency Virus (HIV) persists to be a significant public health issue worldwide. The current strategy for the treatment of HIV infection, Highly Active Antiretroviral Therapy (HAART), has reduced deaths from AIDS r…
View article: Development and validation of HPLC-UV method for quantification of artemether in plasma
Development and validation of HPLC-UV method for quantification of artemether in plasma Open
The pharmacokinetic knowledge of drug is vital for new drug development and to ensure the improvement in its bioavailability.The artemisinin derivative, artemether is a potent and rapidly acting antimalarial drug recommended by WHO.The obj…
View article: Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems
Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems Open
The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalize…
View article: Development and validation of high-performance liquid chromatographic method for quantification of Irinotecan and its active metabolite SN-38 in colon tumor bearing NOD/SCID mice plasma samples: application to pharmacokinetic study
Development and validation of high-performance liquid chromatographic method for quantification of Irinotecan and its active metabolite SN-38 in colon tumor bearing NOD/SCID mice plasma samples: application to pharmacokinetic study Open
Irinotecan (IRT) is an antineoplastic agent widely used in the treatment of various cancers primarily in colorectal cancer. A new, simple and sensitive high-performance liquid chromatography (HPLC) method coupled with fluorescence detector…
View article: Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug
Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug Open
Hot melt extrusion has been used to produce a solid dispersion of the thermolabile drug artemisinin. Formulation and process conditions were optimized prior to evaluation of dissolution and biopharmaceutical performance. Soluplus®, a low T…
View article: Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes
Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes Open
Novel HSA-based nanoparticles offer safe and effective approach for selective targeting of antimalarial drugs.
View article: A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges
A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges Open
Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms. The present review from …