Kevin M. Harris
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View article: Brief report of a pilot test of an audit tool for assurance of Declarations of Interest policy in NICE COVID‐19 guidance production
Brief report of a pilot test of an audit tool for assurance of Declarations of Interest policy in NICE COVID‐19 guidance production Open
Introduction The National Institute for Health and Care Excellence (NICE) UK helps practitioners and commissioners to achieve high‐quality, cost‐effective patient care by publishing relevant evidence‐based recommendations, including guidel…
View article: Data-driven collection development: Text mining college course catalogs
Data-driven collection development: Text mining college course catalogs Open
Academic librarians are trained to develop and manage collections. They rely on their own subject expertise in academic disciplines, input from teaching faculty, and professional training to make informed selections to support institutiona…
View article: OP92 Impact Of Real-World Evidence On Health Technology Assessment And National Guidance For Interventional Procedures: A UK Perspective
OP92 Impact Of Real-World Evidence On Health Technology Assessment And National Guidance For Interventional Procedures: A UK Perspective Open
Introduction The National Institute for Health and Care Excellence (NICE) interventional procedures programme (IPP) issues guidance on the safety and efficacy of new interventional procedures (IPS). The IPP considers a range of evidence fr…
View article: The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses Open
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes ( Zfp36 , Zfp36l1 , and Zfp36l2 ) encode RNA binding proteins that promote the degr…
View article: Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis
Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis Open
Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without adequate treatment, and many report pain long before motor symptoms associated with MS diagnosis. In the most commonly studied rodent model of MS, e…
View article: Early Mortality in Type A Acute Aortic Dissection
Early Mortality in Type A Acute Aortic Dissection Open
Importance Early data revealed a mortality rate of 1% to 2% per hour for type A acute aortic dissection (TAAAD) during the initial 48 hours. Despite advances in diagnostic testing and treatment, this mortality rate continues to be cited be…
View article: Table of Contents
Table of Contents Open
View article: Reckoning with Our Racist Past: An Academic Health Center’s Engagement with History and Health
Reckoning with Our Racist Past: An Academic Health Center’s Engagement with History and Health Open
Academic health centers (AHC) both contribute to and are influenced by the communities they serve. As part of a central commitment to improving human health, there is a need for AHCs to acknowledge their history related to race and racism,…
View article: Iatrogenic aortic dissection of the descending aorta after percutaneous coronary intervention
Iatrogenic aortic dissection of the descending aorta after percutaneous coronary intervention Open
Aortic dissection is a rare and potentially fatal complication of coronary angiography. We report a case of a woman in her late 80s who underwent a left femoral approach coronary angiogram for evaluation of a transcatheter aortic valve rep…
View article: Pleural effusion: a potential surrogate marker for higher-risk patients with acute type B aortic dissections
Pleural effusion: a potential surrogate marker for higher-risk patients with acute type B aortic dissections Open
OBJECTIVES Pleural effusions (PEffs) are known to occur in type B acute aortic dissection (TBAAD). We investigated the relationship between pleural effusion and the development of early or late complications following TBAAD. METHODS The in…
View article: Acute Myocardial Infarction-Like Events in Related Patients With a Desmoplakin-Associated Arrhythmogenic Cardiomyopathy
Acute Myocardial Infarction-Like Events in Related Patients With a Desmoplakin-Associated Arrhythmogenic Cardiomyopathy Open
Patients with familial arrhythmogenic cardiomyopathy typically present with ventricular arrhythmias or progressive heart failure. This paper characterizes a rare presentation of an underlying genetic cardiomyopathy with clinical manifestat…
View article: Impact of a multidisciplinary acute aortic dissection program: Improved outcomes with a comprehensive initial surgical repair strategy
Impact of a multidisciplinary acute aortic dissection program: Improved outcomes with a comprehensive initial surgical repair strategy Open
View article: Surgical stabilization of rib fractures in symptomatic COVID-19: A case report
Surgical stabilization of rib fractures in symptomatic COVID-19: A case report Open
Severe chest wall injury following trauma is a significant contributing factor to respiratory failure and need for mechanical ventilation in multiply injured patients. Surgical stabilization of rib fractures (SSRF) is increasingly consider…
View article: Findings of prosthetic valve endocarditis in the balloon-expandable trans-catheter aortic valve: review of the literature and tips of management
Findings of prosthetic valve endocarditis in the balloon-expandable trans-catheter aortic valve: review of the literature and tips of management Open
Prosthetic valve endocarditis after transcatheter aortic valve implantation (TAVI) is a rare complication associated with a high mortality rate. Nonetheless, the rapid expansion of TAVI in recent years has proportionally increased the numb…
View article: T cell transgressions: Tales of T cell form and function in diverse disease states
T cell transgressions: Tales of T cell form and function in diverse disease states Open
Insights into T cell form, function, and dysfunction are rapidly evolving. T cells have remarkably varied effector functions including protecting the host from infection, activating cells of the innate immune system, releasing cytokines an…
View article: Type A Acute Aortic Dissection Presenting With Cerebrovascular Accident at Advanced Age
Type A Acute Aortic Dissection Presenting With Cerebrovascular Accident at Advanced Age Open
Our aim was to analyze outcomes of patients aged 70 years or above presenting with type A acute aortic dissection (TAAAD) and cerebrovascular accident (CVA). A retrospective analysis of the International Registry of Acute Aortic Dissection…
View article: Cardiology Research Internship for Undergraduate Students Provides Unique Opportunity for Next Generation of Health Care Professionals
Cardiology Research Internship for Undergraduate Students Provides Unique Opportunity for Next Generation of Health Care Professionals Open
View article: Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain
Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain Open
View article: EUS and secretin endoscopic pancreatic function test predict evolution to overt structural changes of chronic pancreatitis in patients with nondiagnostic baseline imaging
EUS and secretin endoscopic pancreatic function test predict evolution to overt structural changes of chronic pancreatitis in patients with nondiagnostic baseline imaging Open
In patients with abdominal pain of suspected pancreatic origin and with nondiagnostic cross-sectional imaging, EUS and ePFT results predict the development of classic CP structural changes over time. These results support EUS and ePFT as e…
View article: Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection
Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection Open
Aortic dissection complicating pregnancy is rare. Most pregnancy-related aortic dissection is due to an aortopathy often not diagnosed until after aortic dissection. In this study, type A aortic dissections were associated with a dilated a…
View article: Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone Open
View article: Impact of the Commercial Introduction of Transcatheter Mitral Valve Repair on Mitral Surgical Practice
Impact of the Commercial Introduction of Transcatheter Mitral Valve Repair on Mitral Surgical Practice Open
Background There has been uncertainty regarding the effect of transcatheter mitral valve repair (TMVr) with MitraClip on cardiac surgical practice. Our aim was to examine the impact of the commercial introduction of TMVr to a comprehensive…
View article: Transesophageal Echocardiography to Diagnose Watchman Device Infection
Transesophageal Echocardiography to Diagnose Watchman Device Infection Open
View article: A treadmill workstation for reading echocardiograms
A treadmill workstation for reading echocardiograms Open
View article: The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection Open
Background Guidelines recommend frequent follow-up after acute aortic dissection (AAD), but optimal rates of follow-up are not clear. Methods We examined rates of imaging and clinic visits in 267 individuals surviving AAD during recommende…
View article: Su1415 – Intestinal Malrotation is Associated with Visceral Hypersensitivity in Adult Patients
Su1415 – Intestinal Malrotation is Associated with Visceral Hypersensitivity in Adult Patients Open
View article: Contemporary Reasons and Clinical Outcomes for Patients With Severe, Symptomatic Aortic Stenosis Not Undergoing Aortic Valve Replacement
Contemporary Reasons and Clinical Outcomes for Patients With Severe, Symptomatic Aortic Stenosis Not Undergoing Aortic Valve Replacement Open
Background: Although aortic valve replacement (AVR) can be lifesaving, many patients with symptomatic aortic stenosis do not undergo appropriate therapy. This study sought to examine the characteristics, outcomes, and reasons for not pursu…
View article: Clinical Impact of Chronic Aortic Regurgitation in Asymptomatic Patients with Native Aortic Valve Stenosis
Clinical Impact of Chronic Aortic Regurgitation in Asymptomatic Patients with Native Aortic Valve Stenosis Open
BackgroundThe pathologic processes of aortic regurgitation (AR) and aortic stenosis (AS) can affect the rate of progression to symptoms differently, and insight into the management of mixed aortic disease is needed. We examined the impact …
View article: Association of Guideline Adherence for Serial Evaluations With Survival and Adverse Clinical Events in Patients With Asymptomatic Severe Aortic Stenosis
Association of Guideline Adherence for Serial Evaluations With Survival and Adverse Clinical Events in Patients With Asymptomatic Severe Aortic Stenosis Open
The findings of this study support the need for close monitoring of patients with asymptomatic severe aortic stenosis and help to validate current guidelines for serial evaluations. These findings also support initiatives to improve guidel…
View article: Why the Delay? Identification of Factors Which Delay Diagnosis of Acute Aortic Dissection
Why the Delay? Identification of Factors Which Delay Diagnosis of Acute Aortic Dissection Open
Patients with acute aortic dissection suffer a high early mortality. However, limited data delineate the factors that contribute to initial delays in establishing the acute aortic dissecti...