Explanipedia

Inflammatory Mechanisms of Dysmenorrhea: Novel Insights From Menstrual Effluent in an Adolescent Cohort Open

Chandrashekara Kyathanahalli, Frank F. Tu, Kevin M. Hellman · 2025

Objective To examine how eicosanoid levels in menstrual effluent of adolescents within 3 years of menarche relate to the severity of menstrual pain. Design Prospective cohort study. Setting Community teaching hospital. Population or Sample…

Seeking the root causes of menstrual pain: A systematic review of biomarkers in menstrual effluent Open

Chandrashekara Kyathanahalli, Frank F. Tu, Gabriela Ashenafi, Margaret S. Schroer, Kevin M. Hellman · 2025

Dysmenorrhea (period pain) affects over 40% of women and is a leading cause of missed school and workdays. However, the molecular mechanisms underlying this pain are not fully understood. We conducted a systematic review (Prospero registra…

A Functional MRI Method to Characterize Uterine Contractility and Menstrual Pain Open

Kendra Juliette, Taytum Kahl, Emmet Hirsch, Frank F. Tu, Kevin M. Hellman · 2025

Background: Dysmenorrhea (menstrual pain) negatively impacts the quality of life for many individuals and is often refractory to treatment. Although the mechanisms responsible for pain are not fully understood, it is widely hypothesized th…

Multiparametric quantitative magnetic resonance imaging of uterine fibroids for prediction of growth rate—a pilot study Open

Milica Medved, Carla Harmath, Hiba Siblini, Mihai Giurcanu, Kirti Kulkarni , et al. · 2024

The mp-qMRI parameters T2, ADC, and UF volume obtained at the time of initial fibroid diagnosis may be able to predict UF growth rate. Mp-qMRI could be integrated into the management of UFs, for individualized care and improved clinical ou…

Ultrasound and magnetic resonance imaging–based investigation of the role of perfusion and oxygen availability in menstrual pain Open

Richard H. Cockrum, Frank F. Tu, Ola Kierzkowska, Nondas Leloudas, Prasad V. Pottumarthi , et al. · 2024

A multidimensional appraisal of early menstrual pain experience Open

Frank F. Tu, Kevin M. Hellman, Sarah E. Darnell, Kaela A. Harber, Amy M. Bohnert , et al. · 2024

Multimodal hypersensitivity derived from quantitative sensory testing predicts pelvic pain outcome: an observational cohort study Open

Matthew J. Kmiecik, Frank F. Tu, Daniel J. Clauw, Kevin M. Hellman · 2023

Multimodal hypersensitivity (MMH)—greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)—is associated with the development of chronic pain. However, previous MMH studies are restricted given their…

Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea Open

Hye-Young Oh, Eli D. Ehrenpreis, Frank F. Tu, Katlyn E. Dillane, Ellen F. Garrison , et al. · 2022

Women frequently report increased bloating, flatulence, and pain during the perimenstrual period. However, it is unknown whether women have more intraluminal gas during menses. To evaluate whether pain-free women or women with dysmenorrhea…

Generalized sensory sensitivity is associated with comorbid pain symptoms: a replication study in women with dysmenorrhea Open

Andrew Schrepf, Kevin M. Hellman, Amy M. Bohnert, David A. Williams, Frank F. Tu · 2022

Dysmenorrhea is characterized by high rates of transition to chronic pain. In a previous study using structural equation modeling, we demonstrated that several symptom domains associated with the emerging concept of nociplastic pain can be…

Multimodal Hypersensitivity Derived from Quantitative Sensory Testing Predicts Long-Term Pelvic Pain Outcome Open

Matthew J. Kmiecik, Frank F. Tu, Daniel J. Clauw, Kevin M. Hellman · 2022

Multimodal hypersensitivity (MMH)—greater sensitivity across multiple sensory modalities (e.g., light, sound, temperature, pressure)—is hypothesized to be responsible for the development of chronic pain and pelvic pain. However, previous s…

Cortical mechanisms of visual hypersensitivity in women at risk for chronic pelvic pain Open

Matthew J. Kmiecik, Frank F. Tu, Rebecca L. Silton, Katlyn E. Dillane, Genevieve E. Roth , et al. · 2021

Increased sensory sensitivity across non-nociceptive modalities is a common symptom of chronic pain conditions and is associated with chronic pain development. Providing a better understanding of the brain–behavior relationships that under…

Noninvasive bladder testing of adolescent females to assess visceral hypersensitivity Open

Frank F. Tu, Kevin M. Hellman, Genevieve E. Roth, Katlyn E. Dillane, Lynn S. Walker · 2021

Excess pain after visceral provocation has been suggested as a marker for chronic pelvic pain risk in women. However, few noninvasive tests have been validated that could be performed readily on youth in early risk windows. Therefore, we e…

Mechanisms, Diagnosis, Prevention and Management of Perioperative Opioid-Induced Hyperalgesia Open

Sylvia H. Wilson, Kevin M. Hellman, Dominika Lipowska James, Adam C. Adler, Arvind Chandrakantan · 2021

Opioid-induced hyperalgesia (OIH) occurs when opioids paradoxically enhance the pain they are prescribed to ameliorate. To address a lack of perioperative awareness, we present an educational review of clinically relevant aspects of the di…

Primary Dysmenorrhea: Diagnosis and Therapy Open

Frank F. Tu, Kevin M. Hellman · 2021

Evanston Hospital, Evanston, Illinois Guidelines for Letters. Letters posing a question or challenge to an article appearing in Obstetrics & Gynecology should be submitted within 8 weeks of the article's publication online. Letters receive…

Development and validation of a real‐time method characterizing spontaneous pain in women with dysmenorrhea Open

Diana Kantarovich, Katlyn E. Dillane, Ellen F. Garrison, Folabomi A. Oladosu, Margaret S. Schroer , et al. · 2021

Aim Prior research has primarily focused on static pain assessment, largely ignoring the dynamic nature of pain over time. We used a novel assessment tool for characterizing pain duration, frequency, and amplitude in women with dysmenorrhe…

362 Functional MRI to assess third trimester placental oxygenation Open

C MacGregor, Kevin M. Hellman, Pottumarthi V. Prasad, Cameron Swope, Alexandria Choi , et al. · 2021

Circulating sex steroids and bladder pain sensitivity in dysmenorrhea Open

Kevin M. Hellman, Folabomi A. Oladosu, Ellen F. Garrison, Genevieve E. Roth, Katlyn E. Dillane , et al. · 2021

Although elevated estradiol levels facilitate chronic pelvic pain in animal models, it remains to be determined whether sex steroid levels are altered in a cross-section of women with chronic pelvic pain (CPP) and those at-risk for develop…

Cortical Mechanisms of Visual Hypersensitivity in Women at Risk for Chronic Pelvic Pain Open

Matthew J. Kmiecik, Frank F. Tu, Rebecca L. Silton, Katlyn E. Dillane, Genevieve E. Roth , et al. · 2020

Multisensory hypersensitivity (MSH), which refers to persistent discomfort across sensory modalities, is a risk factor for chronic pain. Developing a better understanding of the neural contributions of disparate sensory systems to MSH may …

Low Serum Naproxen Concentrations Are Associated with Minimal Pain Relief: A Preliminary Study in Women with Dysmenorrhea Open

Folabomi A. Oladosu, Frank F. Tu, Ellen F. Garrison, Katlyn E. Dillane, Genevieve E. Roth , et al. · 2020

Objective Incomplete pain relief after administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is common, but it is unknown whether malabsorption or heightened metabolism contributes to NSAID resistance. To explain the etiology of …

Dysmenorrhea subtypes exhibit differential quantitative sensory assessment profiles Open

Kevin M. Hellman, Genevieve E. Roth, Katlyn E. Dillane, Ellen F. Garrison, Folabomi A. Oladosu , et al. · 2020

Women who develop bladder pain syndrome (BPS), irritable bowel syndrome, or dyspareunia frequently have an antecedent history of dysmenorrhea. Despite the high prevalence of menstrual pain, its role in chronic pelvic pain emergence remains…

Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation Open

Folabomi A. Oladosu, Frank F. Tu, Lindsey Garfield, Ellen F. Garrison, Nicole D. Steiner , et al. · 2020

Wikipedia: A Medical Student Educational Project to Edit Wikipedia in Preparation for Practicing Evidence-Based Pain Medicine Open

Diana Kantarovich, Hanna Vollbrecht, Sebastian A. Cruz, Héctor Castillo, Cody Lee , et al. · 2020

Objective: Wikipedia is commonly used to acquire information about various medical conditions such as chronic pain. Ideally, better online pain management content could reduce the burden of opioid use disorders. Our goal was to improve the…

Clinical profile of comorbid dysmenorrhea and bladder sensitivity: a cross-sectional analysis Open

Frank F. Tu, Avisek Datta, Diana Atashroo, Sangeeta Senapati, Genevieve E. Roth , et al. · 2019

Persistent autonomic dysfunction and bladder sensitivity in primary dysmenorrhea Open

Folabomi A. Oladosu, Kevin M. Hellman, Paula J. Ham, Laura Kochlefl, Avisek Datta , et al. · 2019

Table of Contents Open

Michael Robson, Luis Sanchez, Agustín Conde-Agudelo, Roberto Romero, Eduardo Da Fonseca , et al. · 2018

Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea Open

Folabomi A. Oladosu, Frank F. Tu, Saaniya Farhan, Ellen F. Garrison, Nicole D. Steiner , et al. · 2018

Identification of experimental bladder sensitivity among dysmenorrhea sufferers Open

Kevin M. Hellman, Avisek Datta, Nicole D. Steiner, Julia N. Kane Morlock, Ellen F. Garrison , et al. · 2018

Table of Contents Open

Dennis Lo, Roberto Romero, Audrey J. Gaskins, Jorge E. Chavarro, Folabomi A. Oladosu , et al. · 2018

Somatic symptoms in women with dysmenorrhea and noncyclic pelvic pain Open

Rebecca M. Zuckerman, Rebecca L. Silton, Frank F. Tu, Joshua S. Eng, Kevin M. Hellman · 2018

Cine MRI during spontaneous cramps in women with menstrual pain Open

Kevin M. Hellman, Caroline Kuhn, Frank F. Tu, Katlyn E. Dillane, Nathan A. Shlobin , et al. · 2018

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