Kevin M. Rattigan
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View article: Mini review of metabolism in leukaemia: from complexity to the clinic
Mini review of metabolism in leukaemia: from complexity to the clinic Open
The importance of metabolism to cancer has increasingly been recognised and this is particularly the case for leukaemia. This has opened the possibility of targeting dysregulated metabolism with the aim of increasing the effectiveness of c…
View article: Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity Open
Our understanding of cancer metabolism spans from its role in cellular energetics and supplying the building blocks necessary for proliferation, to maintaining cellular redox and regulating the cellular epigenome and transcriptome. Cancer …
View article: Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing Open
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully …
View article: Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death Open
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosph…
View article: ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy
ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy Open
ULK1 inhibition increases the sensitivity of leukemia stem cells to TKI therapy by modulating energy and redox balance.
View article: The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion
The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion Open
Objectives Fatty acid oxidation (FAO) and glycolysis have been implicated in immune regulation and activation of macrophages. However, investigation of human monocyte intracellular metabolism in the context of the hypoxic and inflammatory …
View article: P108/O28 Fatty acid oxidation can drive human monocyte derived CCL20 in the RA synovial environment
P108/O28 Fatty acid oxidation can drive human monocyte derived CCL20 in the RA synovial environment Open
View article: Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli Open
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-in…