Kevin Macadaeg
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View article: Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology
Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology Open
The most common cause of radicular leg pain is lumbar disc herniation (LDH). LDH occurs when the central disc material, predominantly the nucleus pulposus, is displaced beyond the margins of the disc, compressing the spinal nerve roots and…
View article: Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation
Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation Open
Study Design. An exploratory analysis of a randomized, double-blind, sham-controlled, phase three study. Objective. To evaluate the impact of SI-6603 (condoliase) on health-related quality of life (HRQoL)-related outcomes in patients with …
View article: Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials
Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials Open
In this 5-year aggregate analysis, BVNA significantly improved pain and function scores compared to baseline. Similarly, there were significant reductions in opioid consumption and spinal injections post BVNA. Data demonstrate a strong saf…
View article: Treatment Gaps and Emerging Therapies in Lumbar Disc Herniation
Treatment Gaps and Emerging Therapies in Lumbar Disc Herniation Open
BACKGROUND: Lumbar disc herniation (LDH) occurs when the central disc material, primarily the nucleus pulposus, is displaced beyond the outer annulus, compressing the spinal nerve roots. LDH symptoms, including radicular leg pain, radiculo…
View article: A phase 3, randomized, double-blind, sham-controlled trial of SI-6603 (condoliase) in patients with radicular leg pain associated with lumbar disc herniation
A phase 3, randomized, double-blind, sham-controlled trial of SI-6603 (condoliase) in patients with radicular leg pain associated with lumbar disc herniation Open
Condoliase met its primary endpoint of significantly improving radicular leg pain at Week 13 and was generally well tolerated in patients with LDH. Chemonucleolysis with condoliase has the potential to provide a less invasive treatment opt…
View article: Intraosseous basivertebral nerve ablation: Pooled long-term outcomes from two prospective clinical trials
Intraosseous basivertebral nerve ablation: Pooled long-term outcomes from two prospective clinical trials Open
Intraosseous BVNA demonstrates statistically significant, clinically meaningful, and durable improvements in pain and function through 3 years in patients with primary vertebrogenic low back pain. BVNA-treated patients significantly reduce…
View article: The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes Following Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials
The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes Following Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials Open
View article: Intraosseous Basivertebral Nerve Ablation: Pooled Long-Term Outcomes from Two Prospective Clinical Trials
Intraosseous Basivertebral Nerve Ablation: Pooled Long-Term Outcomes from Two Prospective Clinical Trials Open
View article: The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes After Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials
The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes After Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials Open
Objective Multiple studies have demonstrated the safety and effectiveness of basivertebral nerve radiofrequency ablation (BVN RFA) for improving low back pain related to the vertebral endplate. However, the influence of patient demographic…
View article: A prospective, single arm study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results
A prospective, single arm study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results Open
View article: Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study
Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study Open
Background Damaged or degenerated vertebral endplates are a significant cause of vertebrogenic chronic low back pain (CLBP). Modic changes are one objective MRI biomarker for these patients. Prior data from the treatment arm of a sham-cont…
View article: A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain
A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain Open
Minimally invasive RF ablation of the BVN demonstrated a significant improvement in pain and function in this population of real-world patients with chronic vertebrogenic-related LBP. These slides can be retrieved under Electronic Suppleme…