Kevin Mou
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View article: Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the <em>Nlgn3<sup>R451C</sup></em> Mouse Model of Autism
Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the <em>Nlgn3<sup>R451C</sup></em> Mouse Model of Autism Open
Individuals with autism often experience gastrointestinal issues but the cause is unknown. Many gene mutations that modify neuronal synapse function are associated with autism and therefore may impact the enteric nervous system that regula…
View article: Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus
Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus Open
Chronic obstructive pulmonary disease (COPD) is a major, incurable respiratory condition that is primarily caused by cigarette smoking (CS). Neurocognitive disorders including cognitive dysfunction, anxiety and depression are highly preval…
View article: Musculoskeletal Crosstalk in Chronic Obstructive Pulmonary Disease and Comorbidities: Emerging Roles and Therapeutic Potentials
Musculoskeletal Crosstalk in Chronic Obstructive Pulmonary Disease and Comorbidities: Emerging Roles and Therapeutic Potentials Open
View article: Inhibition of oxidative stress by apocynin attenuated COPD progression and vascular injury by cigarette smoke exposure
Inhibition of oxidative stress by apocynin attenuated COPD progression and vascular injury by cigarette smoke exposure Open
Background and Purpose: Cardiovascular disease (CVD) affects up to half of the patients with chronic obstructive pulmonary disease (COPD), which exerts deleterious impact on health outcomes and survivability. Vascular endothelial dysfuncti…
View article: Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus
Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus Open
Background and Objective Neurocognitive dysfunction is present in up to ∼61% of people with chronic obstructive pulmonary disease (COPD), with symptoms including learning and memory deficiencies, negatively impacting the quality of life of…
View article: Ebselen Prevents Cigarette Smoke-Induced Cognitive Dysfunction In Mice By Preserving Hippocampal Synaptophysin Expression
Ebselen Prevents Cigarette Smoke-Induced Cognitive Dysfunction In Mice By Preserving Hippocampal Synaptophysin Expression Open
Background: Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive dysfunction. Cessa…
View article: Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice Open
Background and Purpose: People with COPD are susceptible to respiratory infections which exacerbate pulmonary and/or cardiovascular complications, increasing their likelihood of death. The mechanisms driving these complications remain unkn…
View article: Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice
Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice Open
Gastrointestinal (GI) dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD) for which a major cause is cigarette smoking (CS). The underlying mechanisms and precise effects of CS on gut contractility, however,…
View article: Apocynin prevents cigarette smoking-induced loss of skeletal muscle mass and function by preserving proteostatic signalling
Apocynin prevents cigarette smoking-induced loss of skeletal muscle mass and function by preserving proteostatic signalling Open
Background and Purpose: Cigarette smoking (CS) is the major risk factor for developing COPD and related skeletal muscle dysfunction. It has been postulated that CS exposure may directly causes muscle dysfunction via the induction of oxidat…