Kevin Nee
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View article: Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments
Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments Open
Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity derives in part from distinct cancer stem cell populations that co-exist as admixtures of …
View article: SP35. Characterizing Cancer Associated Fibroblasts Across Millions Of Tumor Cells
SP35. Characterizing Cancer Associated Fibroblasts Across Millions Of Tumor Cells Open
Purpose: The initiation, progression, and metastasis of cancer alters the surrounding stroma, termed the tumor microenvironment (TME). The TME is composed of diverse cells, the most abundant of which are the cancer-associated fibroblasts (…
View article: 101. Characterizing Tumor-associated Endothelial And Mural Cells Across Thousands Of Tumors
101. Characterizing Tumor-associated Endothelial And Mural Cells Across Thousands Of Tumors Open
View article: Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model Open
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell acti…
View article: Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model Open
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell acti…
View article: A spatially resolved single-cell genomic atlas of the adult human breast
A spatially resolved single-cell genomic atlas of the adult human breast Open
View article: A spatially resolved single cell genomic atlas of the adult human breast
A spatially resolved single cell genomic atlas of the adult human breast Open
SUMMARY The adult human breast comprises an intricate network of epithelial ducts and lobules that are embedded in connective and adipose tissue. While previous studies have mainly focused on the breast epithelial system, many of the non-e…
View article: Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis Open
View article: Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis
Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis Open
Summary Women with germline mutations in BRCA1 (BRCA1 +/mut ) have increased risk for developing hereditary breast cancer 1, 2 . Cancer initiation in BRCA1 +/mut is associated with pre-malignant changes in the breast epithelium including a…
View article: An <i>in vitro</i> vascularized micro-tumor model of human colorectal cancer recapitulates <i>in vivo</i> responses to standard-of-care therapy
An <i>in vitro</i> vascularized micro-tumor model of human colorectal cancer recapitulates <i>in vivo</i> responses to standard-of-care therapy Open
VMTs recapitulate in vivo drug responses and also reconstitute the cellular diversity of tumors.
View article: An<i>In Vitro</i>Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates<i>In Vivo</i>Drug Responses
An<i>In Vitro</i>Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates<i>In Vivo</i>Drug Responses Open
Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline highlights the need for improved, physiologically-relevant in vitro models that…
View article: Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics Open
Alshetaiwi et al. identify CD84 to be a robust MSDC-specific cell surface marker in breast cancers.
View article: Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics Open
Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the capacity to suppress adaptive immune responses during cancer. It remains elusive how MDSCs differ from their normal myeloid counterparts, which limits our ab…
View article: Single Nuclei RNA Sequencing of Breast Adipose Tissue (10x Nuclei-Seq) v1
Single Nuclei RNA Sequencing of Breast Adipose Tissue (10x Nuclei-Seq) v1 Open
Breast cancer originates in the mammary gland epithelium, however growing evidence demonstrates that the diverse array of stromal tissues influence the behavior of breast epithelium and has key roles in the pathogenesis of breast cancer. D…
View article: Experimental Considerations for Single-Cell RNA Sequencing Approaches
Experimental Considerations for Single-Cell RNA Sequencing Approaches Open
Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Previous scientific knowledge in cell biology is largely limited to data generated by bulk prof…
View article: Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse Open
View article: PGC Reversion to Pluripotency Involves Erasure of DNA Methylation from Imprinting Control Centers followed by Locus-Specific Re-methylation
PGC Reversion to Pluripotency Involves Erasure of DNA Methylation from Imprinting Control Centers followed by Locus-Specific Re-methylation Open
View article: Erratum: MORC1 represses transposable elements in the mouse male germline
Erratum: MORC1 represses transposable elements in the mouse male germline Open
Nature Communications 5, Article number: 5795 (2014); Published: 12 December 2014; Updated: 10 July 2015 This Article contains errors in Fig. 2 that were introduced during the production process. The bars of the graph in panel f were inadv…
View article: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse Open
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment…
View article: Author response: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
Author response: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Methylation of cytosines (5me…
View article: The Aorta-Gonad-Mesonephros Organ Culture Recapitulates 5hmC Reorganization and Replication-Dependent and Independent Loss of DNA Methylation in the Germline
The Aorta-Gonad-Mesonephros Organ Culture Recapitulates 5hmC Reorganization and Replication-Dependent and Independent Loss of DNA Methylation in the Germline Open
Removal of cytosine methylation from the genome is critical for reprogramming and transdifferentiation and plays a central role in our understanding of the fundamental principles of embryo lineage development. One of the major models for s…