Kevin P. Koster
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View article: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex
Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex Open
In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other brain areas…
View article: Author response: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex
Author response: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex Open
View article: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex
Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex Open
In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other brain areas…
View article: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex
Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex Open
In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other brain areas…
View article: Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex
Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex Open
Summary In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other bra…
View article: A tribute to Dr. Akira Yoshii, MD, PhD
A tribute to Dr. Akira Yoshii, MD, PhD Open
View article: Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen
Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen Open
The basal ganglia play pivotal roles in motor control and cognitive functioning. These nuclei are embedded in an anatomical loop: cortex to basal ganglia to thalamus back to cortex. We focus here on an essential synapse for descending cont…
View article: Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II
Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II Open
View article: Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine
Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine Open
Infantile neuronal ceroid lipofuscinosis (CLN1 Batten Disease) is a devastating pediatric lysosomal storage disease caused by pathogenic variants in the CLN1 gene, which encodes the depalmitoylation enzyme, palmitoyl-protein thioesterase 1…
View article: Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus
Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus Open
A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1 L5 ), while another arises from the deep cerebellar nuclei (Cb). M1 L5 terminals distribu…
View article: Author response: Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus
Author response: Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus Open
View article: Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis
Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis Open
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), …
View article: Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus
Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus Open
A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1 L5 ), while another arises from the deep cerebellar nuclei (Cb). M1 L5 terminals distribu…
View article: Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis
Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis Open
Protein palmitoylation is the only reversible post-translational lipid modification. Palmitoylation is held in delicate balance by depalmitoylation to precisely regulate protein turnover. While over 20 palmitoylation enzymes are known, dep…
View article: The Basal Ganglia Gate Inputs from Layer 5 of Motor Cortex and Cerebellum in Mouse Motor Thalamus
The Basal Ganglia Gate Inputs from Layer 5 of Motor Cortex and Cerebellum in Mouse Motor Thalamus Open
View article: Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry
Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry Open
Commensal bacteria are critical regulators of both tissue homeostasis and the development and exacerbation of autoimmunity. However, it remains unclear how the intestinal microbiota contributes to inflammation in tissues such as the centra…
View article: Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease
Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease Open
Summary Palmitoylation and depalmitoylation are the dichotomic processes of lipid modification regulating protein trafficking, recycling, and degradation, thereby controlling proteostasis. Despite our understanding of palmitoylation, depal…
View article: Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration
Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration Open
Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid, palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it robustly modifies the localization and function of …
View article: AMPAR Palmitoylation Tunes Synaptic Strength: Implications for Synaptic Plasticity and Disease
AMPAR Palmitoylation Tunes Synaptic Strength: Implications for Synaptic Plasticity and Disease Open
The addition of lipid moieties to proteins has been studied for nearly 40 years ([Folch and Lees, 1951][1]; [Kamiya et al., 1978][2]; [Schmidt et al., 1979][3]; [Carr et al., 1982][4]), but the scope and diversity of functional consequence…
View article: Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model
Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model Open
Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity. Mutation of the depalmitoylating enzyme palmitoyl-protein thioesterase 1 (PPT1) …
View article: Author response: Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model
Author response: Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model Open
View article: NMDA Receptor Dysregulation by Defective Depalmitoylation in the Infantile Neuronal Ceroid Lipofuscinosis Mouse Model
NMDA Receptor Dysregulation by Defective Depalmitoylation in the Infantile Neuronal Ceroid Lipofuscinosis Mouse Model Open
Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity. Mutation of the depalmitoylating enzyme palmitoyl-protein thioesterase 1 (PPT1) …
View article: Peripheral Inflammation, <i>Apolipoprotein E4</i> , and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction
Peripheral Inflammation, <i>Apolipoprotein E4</i> , and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction Open
Cerebrovascular dysfunction is rapidly reemerging as a major process of Alzheimer's disease (AD). It is, therefore, crucial to delineate the roles of AD risk factors in cerebrovascular dysfunction. While apolipoprotein E4 ( APOE4), Amyloid…
View article: <em>In Vitro</em> Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption
<em>In Vitro</em> Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption Open
Blood-brain barrier (BBB) coverage plays a central role in the homeostasis of the central nervous system (CNS). The BBB is dynamically maintained by astrocytes, pericytes and brain endothelial cells (BECs). Here, we detail methods to asses…
View article: Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits <i>in vitro</i>
Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits <i>in vitro</i> Open
Cerebrovascular dysfunction is a critical component of Alzheimer’s disease (AD) pathogenesis. Oligomeric amyloid-β42 (oAβ42) is considered a major contributor to AD progression. However, data are limited on the role of oAβ42 in brain endot…
View article: Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease Open
View article: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease Open
View article: The role of APOE in cerebrovascular dysfunction
The role of APOE in cerebrovascular dysfunction Open
View article: APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice Open
These findings suggest that compared with E2FAD and E3FAD, E4FAD and 5xFAD/APOE-KO mice exhibit enhanced age-induced reductions in cognition and key synaptic proteins via down-regulation of an NMDAR signaling pathway, consistent with an ap…
View article: <i><scp>APOE</scp></i>‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
<i><span>APOE</span></i>‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective Open
Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ) contribute to Alzheimer's disease ( AD ) pathology. APOE 4 is the greatest AD ‐genetic risk factor; increasing risk up to 12‐fold compared to APOE 3, with…