Kevin Portmann
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View article: EXTH-144. Multifunctional chimeric antigen receptor immune cell communities demonstrate promising preclinical safety and efficacy against glioblastoma
EXTH-144. Multifunctional chimeric antigen receptor immune cell communities demonstrate promising preclinical safety and efficacy against glioblastoma Open
There is an unmet medical need for more effective therapies against glioblastoma. Cellular immunotherapies with engineered immune cells expressing synthetic chimeric antigen receptors (CAR) to recognize and attack cancer cells have great t…
View article: Non-conjugated TLR agonists increase the quantity of antibodies but not their quality in a murine immunization model
Non-conjugated TLR agonists increase the quantity of antibodies but not their quality in a murine immunization model Open
Bacterial vaccines have largely shifted from whole bacteria to selected proteins or glycans, thereby removing immune-stimulant components such as toll-like receptor (TLR) agonists from the formulation. Therefore, TLR agonists are often add…
View article: The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs: a comparative study
The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs: a comparative study Open
Introduction Human peripheral blood mononuclear cells (hPBMCs) are widely used in fundamental research and clinical applications as studying their responses to in vitro activation is an effective way to uncover functional alterations and d…
View article: Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM
Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM Open
Antibodies that trigger the complement system play a pivotal role in the immune defense against pathogenic bacteria and offer potential therapeutic avenues for combating antibiotic‐resistant bacterial infections, a rising global concern. T…
View article: Author response: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Author response: Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
View article: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis
Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis Open
View article: JoVE Video Dataset
JoVE Video Dataset Open
Infections, autoimmune diseases, desired and adverse immunological responses to treatment can lead to a complex and dynamic cytokine response in vivo. This response involves numerous immune cells secreting various cytokines to orchestrate …
View article: Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells Open
Infections, autoimmune diseases, desired and adverse immunological responses to treatment can lead to a complex and dynamic cytokine response in vivo. This response involves numerous immune cells secreting various cytokines to orchestrate …
View article: Reviewer #1 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept
Reviewer #1 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Author Response: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Author Response: Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Reviewer #2 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept
Reviewer #2 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis
Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis Open
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and fun…
View article: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Reviewer #1 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept
Reviewer #1 (Public Review): Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis
Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis Open
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and fun…
View article: Stimulation-induced cytokine polyfunctionality as a dynamic concept
Stimulation-induced cytokine polyfunctionality as a dynamic concept Open
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effecti…
View article: Single-cell deep phenotyping of cytokine release unmasks stimulation-specific biological signatures and distinct secretion dynamics
Single-cell deep phenotyping of cytokine release unmasks stimulation-specific biological signatures and distinct secretion dynamics Open
View article: Single-Cell Deep Phenotyping of Cytokine Release Unmasks Stimulation-Specific Biological Signatures and Distinct Secretion Dynamics
Single-Cell Deep Phenotyping of Cytokine Release Unmasks Stimulation-Specific Biological Signatures and Distinct Secretion Dynamics Open