Kevin R. Bainey
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View article: Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the <scp>MINT</scp> trial
Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the <span>MINT</span> trial Open
Background The aim of this analysis was to quantify and compare the frequency of transfusion‐related adverse events ( TRAE ) in adult patients with myocardial infarction transfused with a restrictive versus liberal transfusion strategy fro…
View article: Efficacy and Safety of Transcatheter Mitral Valve Edge-to-Edge Repair with a MitraClip Device in Real-World Canadian Practice
Efficacy and Safety of Transcatheter Mitral Valve Edge-to-Edge Repair with a MitraClip Device in Real-World Canadian Practice Open
View article: Coronary Computed Tomographic Angiography to Optimize the Diagnostic Yield of Invasive Angiography for Low-Risk Patients Screened With Artificial Intelligence: Protocol for the CarDIA-AI Randomized Controlled Trial
Coronary Computed Tomographic Angiography to Optimize the Diagnostic Yield of Invasive Angiography for Low-Risk Patients Screened With Artificial Intelligence: Protocol for the CarDIA-AI Randomized Controlled Trial Open
Background Invasive coronary angiography (ICA) is the gold standard in the diagnosis of coronary artery disease (CAD). Being invasive, it carries rare but serious risks including myocardial infarction, stroke, major bleeding, and death. A …
View article: Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels
Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels Open
View article: Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction
Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction Open
MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to en…
View article: Stellate Ganglion Block and Bilateral Sympathectomy for Recurrent Coronary Vasospasm Secondary to Severe Eosinophilic Asthma
Stellate Ganglion Block and Bilateral Sympathectomy for Recurrent Coronary Vasospasm Secondary to Severe Eosinophilic Asthma Open
View article: Left Anterior Descending Nonculprit Lesions and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction
Left Anterior Descending Nonculprit Lesions and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Open
Of the 4,041 subjects in COMPLETE, 1,666 patients had a proximal/mid-LAD NCL (41.2%). The first coprimary outcome occurred in 8.5% (2.9%/y) of patients with a proximal/mid-LAD NCL vs 9.9% (3.4%/y) in those without (adjusted HR: 0.83; 95% C…
View article: Hospital and Physician Variability in Revascularization Decisions and Outcomes for Patients With 3‐Vessel and Left Main Coronary Artery Disease: A Population‐Based Cohort Study
Hospital and Physician Variability in Revascularization Decisions and Outcomes for Patients With 3‐Vessel and Left Main Coronary Artery Disease: A Population‐Based Cohort Study Open
Background Hospital‐ and physician‐level variation for selection of percutaneous coronary intervention versus coronary artery bypass grafting (CABG) for patients with coronary artery disease has been associated with outcome differences. Ho…
View article: Restrictive or Liberal Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: 6-Month Mortality in the MINT Trial
Restrictive or Liberal Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: 6-Month Mortality in the MINT Trial Open
View article: Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial
Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial Open
Background and Aims In the AEGIS-II trial (NCT03473223), CSL112, a human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity, did not significantly reduce the risk of the primary endpoint through 90 days vs. pl…
View article: Pulmonary hypertension misdiagnosis due to preventable errors in echocardiography and right heart catheterization
Pulmonary hypertension misdiagnosis due to preventable errors in echocardiography and right heart catheterization Open
Objectives We hypothesized that preventable human errors in performance and reporting of transthoracic echocardiograms (TTEs) and right RHCs are common and may lead to misdiagnosis of pulmonary hypertension (PH) subgroups. Background PH is…
View article: Intravascular Imaging in the Diagnosis and Management of Patients With Suspected Intracoronary Pathologies: A CJC White Paper
Intravascular Imaging in the Diagnosis and Management of Patients With Suspected Intracoronary Pathologies: A CJC White Paper Open
View article: Development and validation of machine learning algorithms based on electrocardiograms for cardiovascular diagnoses at the population level
Development and validation of machine learning algorithms based on electrocardiograms for cardiovascular diagnoses at the population level Open
View article: Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI
Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI Open
Although CSL112 did not significantly reduce the occurrence of the primary study endpoints, patients treated with CSL112 infusions had numerically lower rates of CV death and MI, type-1 MI, and stent thrombosis-related MI compared with pla…
View article: Antithrombotic Therapy in Patients With Atrial Fibrillation and Coronary Artery Disease With Recent or Remote Events: Systematic Review and Meta-analysis
Antithrombotic Therapy in Patients With Atrial Fibrillation and Coronary Artery Disease With Recent or Remote Events: Systematic Review and Meta-analysis Open
In patients with AF and coronary artery disease, using less-aggressive antithrombotic treatment (DPT after PCI or ACS, and OAC alone after remote PCI or ACS) reduced major bleeding, with an increase in stent thrombosis with recent PCI. The…
View article: Potent P2Y12 Inhibitor Selection and De-escalation Strategies in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Systematic Review and Meta-analysis
Potent P2Y12 Inhibitor Selection and De-escalation Strategies in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Systematic Review and Meta-analysis Open
View article: Coronary Artery Fistula: A Diagnostic Dilemma
Coronary Artery Fistula: A Diagnostic Dilemma Open
Coronary artery fistula (CAF), although one of the rare coronary anomalies, is becoming increasingly more detectable in the recent years due to advancements in cardiac diagnostic imaging. Its long-term prognostic implications and importanc…
View article: The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement
The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement Open
View article: Psychosocial Factors of Women Presenting With Myocardial Infarction With or Without Obstructive Coronary Arteries
Psychosocial Factors of Women Presenting With Myocardial Infarction With or Without Obstructive Coronary Arteries Open
View article: Short dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk patients: Systematic review and meta-analysis
Short dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk patients: Systematic review and meta-analysis Open
Introduction Dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) reduces major adverse cardiovascular events (MACE) and stent thrombosis. However, DAPT duration is a concern in high bleeding risk (HBR) patie…
View article: Aspirin for the Primary Prevention of Vascular Ischemic Events: An Updated Systematic Review and Meta-analysis to Support Shared Decision-Making
Aspirin for the Primary Prevention of Vascular Ischemic Events: An Updated Systematic Review and Meta-analysis to Support Shared Decision-Making Open
ASA use in primary prevention is associated with a consistent reduction in MACE, but at the expense of major bleeding events. Patient values and preferences should be taken into account when considering ASA use for primary prevention.
View article: Systemic Lupus Erythematosus: Initial Manifestation as Cardiac Tamponade?
Systemic Lupus Erythematosus: Initial Manifestation as Cardiac Tamponade? Open
A 49-year-old man presented with 1 hour of retrosternal chest pain and ST-segment elevation. In the ambulance, he was diagnosed with an ST-segment elevation myocardial infarction and received prompt fibrinolysis. On arrival to the percutan…
View article: STREAM-2: Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction: A Randomized, Open-Label Trial
STREAM-2: Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction: A Randomized, Open-Label Trial Open
BACKGROUND: ST-segment–elevation myocardial infarction (STEMI) guidelines recommend pharmaco-invasive treatment if timely primary percutaneous coronary intervention (PCI) is unavailable. Full-dose tenecteplase is associated with an increas…
View article: Outcomes Among Patients Hospitalized With Non–COVID-19 Conditions Before and During the COVID-19 Pandemic in Alberta and Ontario, Canada
Outcomes Among Patients Hospitalized With Non–COVID-19 Conditions Before and During the COVID-19 Pandemic in Alberta and Ontario, Canada Open
Importance The association of inpatient COVID-19 caseloads with outcomes in patients hospitalized with non–COVID-19 conditions is unclear. Objective To determine whether 30-day mortality and length of stay (LOS) for patients hospitalized w…
View article: Comparative Analysis of Patients With STEMI and COVID-19 Between Canada and the United States
Comparative Analysis of Patients With STEMI and COVID-19 Between Canada and the United States Open
View article: Sex-Based Differences in Severe Outcomes, Including Cardiovascular Hospitalization, in Adults With COVID-19 in Ontario, Canada
Sex-Based Differences in Severe Outcomes, Including Cardiovascular Hospitalization, in Adults With COVID-19 in Ontario, Canada Open
View article: Towards artificial intelligence-based learning health system for population-level mortality prediction using electrocardiograms
Towards artificial intelligence-based learning health system for population-level mortality prediction using electrocardiograms Open
The feasibility and value of linking electrocardiogram (ECG) data to longitudinal population-level administrative health data to facilitate the development of a learning healthcare system has not been fully explored. We developed ECG-based…
View article: Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction
Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction Open
Importance In patients with multivessel coronary artery disease (CAD) presenting with ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared with culprit lesion–only perc…
View article: Cardiovascular and Renal Implications of Myocardial Infarction in the ISCHEMIA-CKD Trial
Cardiovascular and Renal Implications of Myocardial Infarction in the ISCHEMIA-CKD Trial Open
Background: ISCHEMIA-CKD (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches—Chronic Kidney Disease) reported an initial invasive treatment strategy did not reduce the risk of death or nonfatal myo…
View article: Percutaneous coronary intervention with peripheral artery disease in the contemporary era: Still life or limb?
Percutaneous coronary intervention with peripheral artery disease in the contemporary era: Still life or limb? Open