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View article: Mixed methods evaluation of a digital tool to support the transfer of medication information from ICU to ward
Mixed methods evaluation of a digital tool to support the transfer of medication information from ICU to ward Open
There is significant potential for technology to support transfer of medication information from ICU to the ward and improve safety if technology is designed well and aligns with how work is done in practice.
A Novel Window Into Human Vascular Remodeling and Diagnosing Carotid Flow Impairment: The Petro‐Occipital Venous Plexus Open
Background Adaptive arterial remodeling caused by flow reduction from downstream stenosis has been demonstrated in animal studies. The authors sought to determine whether inward remodeling from downstream stenosis also occurs in humans and…
Normal BOLD Response to a Step CO2 Stimulus After Correction for Partial Volume Averaging Open
Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow induced by a change in a vasoactive stimulus. CVR using BOLD MRI in combination with changes in end-tidal CO 2 is a very useful method for assessing vascular …
The Effect of CO2 on Resting-State Functional Connectivity: Isocapnia vs. Poikilocapnia Open
The normal variability in breath size and frequency results in breath-to-breath variability of end-tidal PCO 2 (P ET CO 2 ), the measured variable, and arterial partial pressure of carbon dioxide (PaCO 2 ), the independent variable affecti…
The Reproducibility of Cerebrovascular Reactivity Across MRI Scanners Open
Cerebrovascular reactivity (CVR) is defined as the ratio of the cerebral blood flow (CBF) response to an increase in a vasoactive stimulus. We used changes in blood oxygenation level-dependent (BOLD) MRI as surrogates for changes of CBF, a…
Cerebrovascular Reactivity Assays Collateral Function in Carotid Stenosis Open
In patients with carotid artery stenosis (CAS), the risk of stroke, its severity, and response to revascularization are strongly related to the availability of collateral blood flow. Unfortunately, there is poor agreement between observers…
View article: CJN volume 47 issue 3 Cover and Front matter
CJN volume 47 issue 3 Cover and Front matter Open
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Collateral Recruitment Is Impaired by Cerebral Small Vessel Disease Open
Background and Purpose— Cerebral small vessel disease (SVD) is associated with increased stroke risk and poor stroke outcomes. We aimed to evaluate whether chronic SVD burden is associated with poor recruitment of collaterals in large-vess…
Slowed Temporal and Parietal Cerebrovascular Response in Patients with Alzheimer’s Disease Open
Background: Recent investigations now suggest that cerebrovascular reactivity (CVR) is impaired in Alzheimer’s disease (AD) and may underpin part of the disease’s neurovascular component. However, our understanding of the relationship betw…
The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities Open
The purpose of this study was to determine the relationship between the organization of the brain connectome and cerebrovascular reactivity (CVR) in persons with white matter hyperintensities. Diffusion tensor and CVR mapping 3T MRI scans …
The Role of Near-infrared Spectroscopy in Cerebral Autoregulation Monitoring Open
Departments of *Anesthesiology and Critical Care Medicine †Radiology and Radiological Science ‖Neurology, Johns Hopkins University School of Medicine Baltimore, MD ‡Joint Department of Medical Imaging Division of Neuroradiology, University…
Cerebrovascular Resistance in Healthy Aging and Mild Cognitive Impairment Open
Measures of cerebrovascular reactivity (CVR) are used to judge the health of the brain vasculature. In this study, we report the use of several different analyses of blood oxygen dependent (BOLD) fMRI responses to CO2 to provide a number o…
Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease Open
Cerebral revascularization surgery is an effective treatment for reversing preoperative cerebrovascular reactivity deficits in WM. In addition, direct-STA-MCA bypass may prevent recurrence of preoperative symptoms.
Cerebrovascular Resistance: The Basis of Cerebrovascular Reactivity Open
The cerebral vascular network regulates blood flow distribution by adjusting vessel diameters, and consequently resistance to flow, in response to metabolic demands (neurovascular coupling) and changes in perfusion pressure (autoregulation…
The role of vascular resistance in BOLD responses to progressive hypercapnia Open
The ability of the cerebral vasculature to regulate vascular diameter, hence resistance and cerebral blood flow (CBF), in response to metabolic demands (neurovascular coupling), and perfusion pressure changes (autoregulation) may be assess…
Assessing cerebrovascular reactivity by the pattern of response to progressive hypercapnia Open
Cerebral blood flow responds to a carbon dioxide challenge, and is often assessed as cerebrovascular reactivity, assuming a linear response over a limited stimulus range or a sigmoidal response over a wider range. However, these assumed re…
Invalidation of fMRI experiments secondary to neurovascular uncoupling in patients with cerebrovascular disease Open
Purpose Blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) is a technique used to infer neuronal activity from the observed changes in blood flow. Cerebrovascular reactivity (CVR) is the ability of arterioles …
Cerebrovascular reactivity and white matter integrity Open
Impaired CVR is associated with subtle changes in the tissue integrity of NAWM, as evaluated using several quantitative diffusion and perfusion MRI metrics. These findings suggest that impaired CVR may contribute to the progression of whit…
Vascular Dysfunction in Leukoaraiosis Open
Not only were resting blood flow metrics abnormal in leukoaraiosis but there is also evidence of reduced cerebrovascular reactivity in these areas. Studies have shown that reduced cerebrovascular reactivity is more sensitive than resting b…
Diminished cerebrovascular reserve in the cerebral white matter of elderly individuals with leukoaraiosis Open
The cerebral white matter contains millions of fibers that serve to connect different regions of the brain and supports sophisticated information processing. A sudden loss of these fibers in a brain region as seen in a stroke to a large bl…
Identifying Significant Changes in Cerebrovascular Reactivity to Carbon Dioxide Open
Accounting for normal test-to-test differences in cerebrovascular reactivity enables the assessment of significant changes in disease status (stability, progression, or regression) in patients with time.
Impaired dynamic cerebrovascular response to hypercapnia predicts development of white matter hyperintensities Open
Vascular impairment in regions of NAWM that progresses to WMH consists not only of decreased magnitude of ssCVR, but also a pathological decrease in the speed of vascular response. These findings support the association between cerebrovasc…