Kevin Struhl
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View article: Location of polyadenylation sites within 3′ untranslated regions is linked to biological function in yeast
Location of polyadenylation sites within 3′ untranslated regions is linked to biological function in yeast Open
Expression of a typical yeast gene results in ∼50 3′ mRNA isoforms that are distinguished by the locations of poly(A) sites within the 3′ untranslated regions (3′ UTRs). The location of poly(A) sites with respect to the translational termi…
View article: Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate Open
The RNA polymerase II (Pol II) elongation rate influences poly(A) site selection, with slow and fast Pol II derivatives causing upstream and downstream shifts, respectively, in poly(A) site utilization. In yeast, depletion of either of the…
View article: How is polyadenylation restricted to 3′‐untranslated regions?
How is polyadenylation restricted to 3′‐untranslated regions? Open
Polyadenylation occurs at numerous sites within 3′‐untranslated regions (3′‐UTRs) but rarely within coding regions. How does Pol II travel through long coding regions without generating poly(A) sites, yet then permits promiscuous polyadeny…
View article: eLife assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline
eLife assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Peer review Author response Article and author information Abstract Spermatogenesis in the Drosophila ma…
View article: eLife assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline
eLife assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline Open
Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and by testis-specific versions of core transcriptional machinery. This program in…
View article: Elongation rate of RNA polymerase II affects pausing patterns across 3′ UTRs
Elongation rate of RNA polymerase II affects pausing patterns across 3′ UTRs Open
Yeast mRNAs are polyadenylated at multiple sites in their 3' untranslated regions (3' UTRs), and poly(A) site usage is regulated by the rate of transcriptional elongation by RNA polymerase II (Pol II). Slow Pol II derivatives favor upstrea…
View article: eLife Assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline
eLife Assessment: Chromosome-specific maturation of the epigenome in the Drosophila male germline Open
Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and by testis-specific versions of core transcriptional machinery. This program in…
View article: How is polyadenylation restricted to 3' untranslated regions?
How is polyadenylation restricted to 3' untranslated regions? Open
Polyadenylation occurs at numerous sites within 3’ untranslated regions (3’ UTRs) but rarely within coding regions. How does Pol II travel through long coding regions without generating poly(A) sites, yet then permits promiscuous polyadeny…
View article: Condition-specific 3′ mRNA isoform half-lives and stability elements in yeast
Condition-specific 3′ mRNA isoform half-lives and stability elements in yeast Open
Alternative polyadenylation generates numerous 3′ mRNA isoforms that can differ in their stability, structure, and function. These isoforms can be used to map mRNA stabilizing and destabilizing elements within 3′ untranslated regions (3′UT…
View article: Data from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
Data from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation Open
The growth and survival of tumor cells in an unfavorable hypoxic environment depend upon their adaptability. Here, we show that both normal and tumor cells expressing the protein kinase Akt2 are more resistant to hypoxia than cells express…
View article: Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types Open
Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
View article: Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation Open
Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
View article: Data from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
Data from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation Open
The growth and survival of tumor cells in an unfavorable hypoxic environment depend upon their adaptability. Here, we show that both normal and tumor cells expressing the protein kinase Akt2 are more resistant to hypoxia than cells express…
View article: Data from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
Data from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types Open
Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts, injection of metfor…
View article: Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation Open
Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
View article: Data from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Data from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation Open
MicroRNA profiling in isogenic models of cellular transformation involving either breast epithelial cells or fibroblasts reveals that expression of miR-193a is lower in transformed cells than in nontransformed cells. The transcription fact…
View article: Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation Open
Supplementary Figures 1-2 from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
View article: Data from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
Data from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types Open
Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts, injection of metfor…
View article: Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types Open
Supplementary Methods from Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
View article: Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation Open
Supplementary Figures 1-18, Methods from Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
View article: Data from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Data from Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation Open
MicroRNA profiling in isogenic models of cellular transformation involving either breast epithelial cells or fibroblasts reveals that expression of miR-193a is lower in transformed cells than in nontransformed cells. The transcription fact…
View article: Nucleotide-level linkage of transcriptional elongation and polyadenylation
Nucleotide-level linkage of transcriptional elongation and polyadenylation Open
Alternative polyadenylation yields many mRNA isoforms whose 3’ termini occur disproportionately in clusters within 3’ untranslated regions. Previously, we showed that profiles of poly(A) site usage are regulated by the rate of transcriptio…
View article: Author response: Nucleotide-level linkage of transcriptional elongation and polyadenylation
Author response: Nucleotide-level linkage of transcriptional elongation and polyadenylation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Alternative polyadenyl…
View article: High level and molecular nature of transcriptional noise in yeast cells
High level and molecular nature of transcriptional noise in yeast cells Open
“Biological noise” is defined as functionally insignificant events that occur in living cells due to imperfect fidelity of biological processes. Distinguishing between biological function and biological noise is often difficult, and experi…
View article: Nucleotide level linkage of transcriptional elongation and polyadenylation
Nucleotide level linkage of transcriptional elongation and polyadenylation Open
Alternative polyadenylation yields many mRNA isoforms whose 3’ termini occur disproportionately in clusters within 3’ UTRs. Previously, we showed that profiles of poly(A) site usage are regulated by the rate of transcriptional elongation b…